CA2046146A1 - Derives de pyrrole - Google Patents

Derives de pyrrole

Info

Publication number
CA2046146A1
CA2046146A1 CA2046146A CA2046146A CA2046146A1 CA 2046146 A1 CA2046146 A1 CA 2046146A1 CA 2046146 A CA2046146 A CA 2046146A CA 2046146 A CA2046146 A CA 2046146A CA 2046146 A1 CA2046146 A1 CA 2046146A1
Authority
CA
Canada
Prior art keywords
optionally substituted
lower alkyl
aryl
aralkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2046146A
Other languages
English (en)
Other versions
CA2046146C (fr
Inventor
Kentaro Hirai
Teruyuki Ishiba
Haruo Koike
Masamichi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2046146A1 publication Critical patent/CA2046146A1/fr
Application granted granted Critical
Publication of CA2046146C publication Critical patent/CA2046146C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002046146A 1990-07-05 1991-07-03 Derives de pyrrole Expired - Fee Related CA2046146C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17856490 1990-07-05
JP178564/1990 1990-07-05

Publications (2)

Publication Number Publication Date
CA2046146A1 true CA2046146A1 (fr) 1992-01-06
CA2046146C CA2046146C (fr) 1997-02-25

Family

ID=16050690

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002046146A Expired - Fee Related CA2046146C (fr) 1990-07-05 1991-07-03 Derives de pyrrole

Country Status (10)

Country Link
US (1) US5128366A (fr)
EP (1) EP0464845B1 (fr)
JP (1) JP3068665B2 (fr)
KR (1) KR0167781B1 (fr)
AT (1) ATE138909T1 (fr)
CA (1) CA2046146C (fr)
DE (1) DE69119979T2 (fr)
DK (1) DK0464845T3 (fr)
ES (1) ES2090177T3 (fr)
GR (1) GR3020689T3 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687146B1 (fr) * 1992-02-12 1994-04-01 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4243279A1 (de) * 1992-12-21 1994-06-23 Bayer Ag Substituierte Triole
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US6962999B2 (en) 2001-07-25 2005-11-08 Pharmacore, Inc. Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
EP1675583B1 (fr) * 2003-10-29 2013-02-27 Wyeth LLC Compositions pharmaceutiques a liberation prolongée contenant de l'aplindore et ses derives
KR101178747B1 (ko) 2004-09-30 2012-09-03 다케다 야쿠힌 고교 가부시키가이샤 프로톤 펌프 저해제
UA94424C2 (en) 2005-08-30 2011-05-10 Такеда Фармасьютикал Компани Лимитед 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors
US8933105B2 (en) 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
KR100856133B1 (ko) * 2008-01-11 2008-09-03 조동옥 아토르바스타틴의 개선된 제조방법
ES2423289T3 (es) 2008-08-27 2013-09-19 Takeda Pharmaceutical Company Limited Compuestos de pirrol
EP3698797A1 (fr) 2017-10-16 2020-08-26 Tsinghua University Inhibiteur de la voie de l'acide mévalonique et composition pharmaceutique correspondante

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987002662A2 (fr) * 1985-10-25 1987-05-07 Sandoz Ag Analogues heterocycliques de mevalonolactone et leurs derives, procedes de production et utilisation en tant que produits pharmaceutiques
NO881411L (no) * 1987-04-14 1988-10-17 Bayer Ag Substituerte pyrroler.
IT1215578B (it) * 1987-06-24 1990-02-14 Roussel Maestretti Spa Derivati di 1-arilsolfonil1,5-diidro 2h-pirrol 2-one, loro procedimento di preparazione e loro applicazione come sostanze medicinali.
DE3722806A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis

Also Published As

Publication number Publication date
KR0167781B1 (ko) 1999-01-15
ES2090177T3 (es) 1996-10-16
DE69119979D1 (de) 1996-07-11
US5128366A (en) 1992-07-07
JPH04352767A (ja) 1992-12-07
JP3068665B2 (ja) 2000-07-24
DE69119979T2 (de) 1996-10-24
CA2046146C (fr) 1997-02-25
ATE138909T1 (de) 1996-06-15
KR920002536A (ko) 1992-02-28
GR3020689T3 (en) 1996-10-31
EP0464845A1 (fr) 1992-01-08
DK0464845T3 (da) 1996-06-24
EP0464845B1 (fr) 1996-06-05

Similar Documents

Publication Publication Date Title
CA2173150A1 (fr) Nouveau derive peptidique
CA2046146A1 (fr) Derives de pyrrole
CA2165819A1 (fr) Derives de dc-89
PL327169A1 (en) Naphtyl-substituted derivatives of benzimidazole as anticoagulants
CA2203878A1 (fr) Certains derives de benzylamine a substitutions; une nouvelle classe de ligands specifiques du neuropeptide y1
CA2368095A1 (fr) Procede permettant de preparer des inhibiteurs du metabolisme des nucleosides
CA2095587A1 (fr) Procede de preparation de composes heterocycliques arylpiperazinyliques
CA2093403A1 (fr) Agent de traitement de la maladie de parkinson
CA2241092A1 (fr) Derives de 1-methylcarbapenem
CA2090509A1 (fr) Procede pour la preparation d'antagonistes du recepteur du fibrinogene
CA2216633A1 (fr) Synthese de bisindolylmaleimides
ATE254127T1 (de) Stabilisierte carbapenem-zwischenprodukteund ihre verwendung in der synthese
GR3017571T3 (en) 2'-fluorofuranosyl derivatives and novel method of preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides.
EP1020446A4 (fr) Derives de naphtalimidobenzamide
CA2222204A1 (fr) Procede de conversion de 2,4-dichloropyridines en 2-aryloxy-4-chloropyridines
CA2100637A1 (fr) Procede d'obtention de 5-chlorimidazole-4-carbaldehydes a substituant en 2
CA2530163A1 (fr) Procede et composes intermediaires servant a la preparation de statines, notamment d'atorvastatine
CA2136597A1 (fr) Derives hydrazine et leurs utilisations
CA2137036A1 (fr) Procede de preparation de derives de diazoniabicycloalcane difluores
YU74501A (sh) Sinteza 3-amino-3-aril propionata
CA2006734A1 (fr) Derives de carboximidamide
CA2289512A1 (fr) Derives de 1,2,3-thiadiazole, agent regulant les maladies des vegetaux et procede d'utilisation de ces derives
CA2051394A1 (fr) Composes macromoleculaires spiropyrane
CA2091304A1 (fr) Derives de substitution d'imidazole
CA2000399A1 (fr) Thienylethylamines substituees et procede de production

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20050704