CA2037907A1 - Homologous recombination for universal donor cells and chimeric mammalian hosts - Google Patents
Homologous recombination for universal donor cells and chimeric mammalian hostsInfo
- Publication number
- CA2037907A1 CA2037907A1 CA002037907A CA2037907A CA2037907A1 CA 2037907 A1 CA2037907 A1 CA 2037907A1 CA 002037907 A CA002037907 A CA 002037907A CA 2037907 A CA2037907 A CA 2037907A CA 2037907 A1 CA2037907 A1 CA 2037907A1
- Authority
- CA
- Canada
- Prior art keywords
- homologous recombination
- mammalian hosts
- donor cells
- universal donor
- chimeric mammalian
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. particularly, the .beta.2-microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38565189A | 1989-07-25 | 1989-07-25 | |
US385,651 | 1989-07-25 | ||
US43187289A | 1989-11-06 | 1989-11-06 | |
US431,872 | 1989-11-06 | ||
PCT/US1990/004178 WO1991001140A1 (en) | 1989-07-25 | 1990-07-25 | Homologous recombination for universal donor cells and chimeric mammalian hosts |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2037907A1 true CA2037907A1 (en) | 1991-01-26 |
CA2037907C CA2037907C (en) | 2006-04-04 |
Family
ID=36143205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002037907A Expired - Lifetime CA2037907C (en) | 1989-07-25 | 1990-07-25 | Homologous recombination for universal donor cells and chimeric mammalian hosts |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2037907C (en) |
-
1990
- 1990-07-25 CA CA002037907A patent/CA2037907C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2037907C (en) | 2006-04-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKEC | Expiry (correction) |
Effective date: 20121202 |