MX9603037A - Materials and methods for management of hyperacute rejection in human xenotransplantation. - Google Patents

Materials and methods for management of hyperacute rejection in human xenotransplantation.

Info

Publication number
MX9603037A
MX9603037A MX9603037A MX9603037A MX9603037A MX 9603037 A MX9603037 A MX 9603037A MX 9603037 A MX9603037 A MX 9603037A MX 9603037 A MX9603037 A MX 9603037A MX 9603037 A MX9603037 A MX 9603037A
Authority
MX
Mexico
Prior art keywords
materials
methods
alpha
disclosed
galactosyltransferase
Prior art date
Application number
MX9603037A
Other languages
Spanish (es)
Inventor
Martin J Pearse
Robert J Crawford
Allan J Robbins
Peter D Rathjen
Anthony J F D Apice
Original Assignee
Bresatec Ltd.
St. Vincent's Hospital (Melbourne)
Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/378,617 external-priority patent/US5849991A/en
Application filed by Bresatec Ltd., St. Vincent's Hospital (Melbourne), Limited filed Critical Bresatec Ltd.
Priority claimed from PCT/IB1995/000088 external-priority patent/WO1995020661A1/en
Publication of MX9603037A publication Critical patent/MX9603037A/en

Links

Abstract

Human pre-formed xenoantibodies play an important role in the hyperacute rejection response in human xenotransplantation. Disclosed are materials and methods for removing or neutralizing such antibodies. Also disclosed are materials and methods for reducing or eliminating the epitopes in the donor organs that are recognized by such antibodies. Such epitopes are formed as the result of activity by the enzyme 'alpha'-1,3 galactosyltransferase. The porcine gene encoding 'alpha'-1,3 galactosyltransferase is disclosed, as are materials and methods for inactivating ("knocking out") the 'alpha'-1,3 galactosyltransferase gene in mammalian cells and embryos. Included are nucleic acid constructs useful for inactivating the 'alpha'-1,3 galactosyltransferase gene in a target cell. Also disclosed is a novel leukemia inhibitory factor (T-LIF) that is useful for maintenance of embryonic stem cells and primordial germ cells in culture.
MX9603037A 1995-01-26 1995-01-27 Materials and methods for management of hyperacute rejection in human xenotransplantation. MX9603037A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/378,617 US5849991A (en) 1994-01-27 1995-01-26 Mice homozygous for an inactivated α 1,3-galactosyl transferase gene
PCT/IB1995/000088 WO1995020661A1 (en) 1994-01-27 1995-01-27 Materials and methods for management of hyperacute rejection in human xenotransplantation

Publications (1)

Publication Number Publication Date
MX9603037A true MX9603037A (en) 1998-01-31

Family

ID=39164857

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603037A MX9603037A (en) 1995-01-26 1995-01-27 Materials and methods for management of hyperacute rejection in human xenotransplantation.

Country Status (1)

Country Link
MX (1) MX9603037A (en)

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