CA2033176A1 - Proteines de fusion d'hormones de croissance - Google Patents

Proteines de fusion d'hormones de croissance

Info

Publication number
CA2033176A1
CA2033176A1 CA2033176A CA2033176A CA2033176A1 CA 2033176 A1 CA2033176 A1 CA 2033176A1 CA 2033176 A CA2033176 A CA 2033176A CA 2033176 A CA2033176 A CA 2033176A CA 2033176 A1 CA2033176 A1 CA 2033176A1
Authority
CA
Canada
Prior art keywords
growth hormone
growth
polypeptide
fusion proteins
fusion protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2033176A
Other languages
English (en)
Other versions
CA2033176C (fr
Inventor
Julian Richard Este Wells
Robert Michael King
Geoffrey Leonard Francis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes Biopharma DK AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2033176A1 publication Critical patent/CA2033176A1/fr
Application granted granted Critical
Publication of CA2033176C publication Critical patent/CA2033176C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

L'invention se rapporte à un plasmide codant pour une protéine de fusion, comprenant un premier polypeptide produisant une activité d'hormone de croissance et un second polypeptide, lequel peut être constitué par un polypeptide du facteur de croissance d'insuline (IGF)-I ou IGF-II et de leurs analogues, de l'histone de poulet H2A.I ou des facteurs de transcription humaine SPI-Lac Z, une séquence de clivage optionnelle pouvant être placée entre le premier et le seocnd polypeptide. Cette protéine de fusion peut être utilisée: 1) pour traiter des déficiences de l'hormone de croissance; 2) pour supprimer les pertes de protéines corporelles à la suite d'un trauma, tel que brûlures ou infections; 3) pour augmenter les taux de croissance et l'efficacité de la transformation des aliments chez les animaux d'élevage; et 4) pour soutenir la croissance de cellules en culture.
CA002033176A 1989-06-09 1990-05-22 Proteines de fusion d'hormones de croissance Expired - Lifetime CA2033176C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPJ4672 1989-06-09
AUPJ467289 1989-06-09
PCT/AU1990/000210 WO1990015142A1 (fr) 1989-06-09 1990-05-22 Proteines de fusion pour hormones de croissance

Publications (2)

Publication Number Publication Date
CA2033176A1 true CA2033176A1 (fr) 1990-12-10
CA2033176C CA2033176C (fr) 1999-12-14

Family

ID=3773983

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002033176A Expired - Lifetime CA2033176C (fr) 1989-06-09 1990-05-22 Proteines de fusion d'hormones de croissance

Country Status (6)

Country Link
US (1) US5330971A (fr)
EP (1) EP0429586B1 (fr)
AT (1) ATE125869T1 (fr)
CA (1) CA2033176C (fr)
DE (1) DE69021335T2 (fr)
WO (1) WO1990015142A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977307A (en) * 1989-09-07 1999-11-02 Alkermes, Inc. Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
ATE165008T1 (de) * 1990-02-13 1998-05-15 Gropep Pty Ltd Methode zur behandlung intestinaler krankheiten
US5679771A (en) * 1990-02-13 1997-10-21 Gropep Pty. Ltd. Method for treating intestinal diseases
US5210017A (en) * 1990-11-19 1993-05-11 Genentech, Inc. Ligand-mediated immunofunctional hormone binding protein assay method
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
ATE314479T1 (de) * 1992-05-18 2006-01-15 Genentech Inc Aktivierung von rezeptoren fähig zur oligomerisierung durch verwendung von fusionierten rezeptor liganden
US5684136A (en) * 1992-05-18 1997-11-04 Genentech, Inc. Chimeric hepatocyte growth factor (HGF) ligand variants
WO1993025226A1 (fr) * 1992-06-08 1993-12-23 Kabi Pharmacia Ab Utilisation du facteur de croissance igf-i et/ou igf-ii
NZ243071A (en) * 1992-06-08 1994-09-27 Kabi Pharmacia Ab Igf-2 (or analogue) compositions for pharmaceutical uses
US5444045A (en) * 1992-09-17 1995-08-22 Gropep, Pty. Ltd. Method of administering IGF-1, IGF-2, and analogs thereof to birds
AU1178395A (en) * 1993-11-12 1995-05-29 North Shore University Hospital Research Corporation Method of treating muscular dystrophy
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
CA2321026A1 (fr) * 1998-03-09 1999-09-16 Zealand Pharmaceuticals A/S Conjugues peptidiques pharmacologiquement actifs ayant une tendance reduite a l'hydrolyse enzymatique
AUPP298498A0 (en) * 1998-04-17 1998-05-07 Gropep Pty Ltd Matrix binding factor
WO2000034312A1 (fr) * 1998-12-10 2000-06-15 Samyang Genex Corporation Procede de purification de peptides antimicrobiens
AUPQ387599A0 (en) * 1999-11-05 1999-12-02 Metabolic Pharmaceuticals Limited Product and method for control of obesity
CN1296974A (zh) * 1999-11-23 2001-05-30 上海博容基因开发有限公司 一种新的多肽——人组蛋白h2a.21和编码这种多肽的多核苷酸
JP2003530839A (ja) 2000-04-12 2003-10-21 プリンシピア ファーマスーティカル コーポレイション アルブミン融合タンパク質
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
JP4173732B2 (ja) * 2000-11-28 2008-10-29 プレマキュア・アクチボラグ 未熟児合併症のリスクの決定および治療
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2003030821A2 (fr) * 2001-10-05 2003-04-17 Human Genome Sciences, Inc. Proteines de fusion d'albumine
WO2005003296A2 (fr) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Proteines hybrides d'albumine
EP2261250B1 (fr) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. Protéines de fusion d'albumine et GCSF
US7355018B2 (en) 2003-09-30 2008-04-08 Regeneron Pharmaceuticals, Inc. Modified IGF1 polypeptides with increased stability and potency
ES2541810T3 (es) * 2005-01-07 2015-07-24 Regeneron Pharmaceuticals, Inc. Polipéptidos de fusión IGF-1 y usos terapéuticos de los mismos
EP1841443A4 (fr) * 2005-01-11 2012-05-02 Heart Failure Technologies Inc Methode et systeme pour le traitement de l'insuffisance cardiaque
WO2007068053A1 (fr) * 2005-12-15 2007-06-21 Gropep Limited Production de protéines par voie recombinante
WO2008035230A2 (fr) * 2006-09-18 2008-03-27 Novozymes Gropep Limited Compositions protéiques liquides
PE20161326A1 (es) 2014-04-10 2016-12-11 Bayer Healthcare Llc Formulacion en polvo de medio de compuesto y metodo de preparacion de medio liquido para cultivo celular
US11136551B2 (en) 2015-09-01 2021-10-05 Ncardia B.V. In vitro method of differentiating a human pluripotent stem cell population into a cardiomyocyte cell population

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK108685A (da) * 1984-03-19 1985-09-20 Fujisawa Pharmaceutical Co Vaekstfaktor i
US5028531A (en) * 1984-03-19 1991-07-02 Fujisawa Pharmaceutical Company, Ltd. IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof
WO1987001038A1 (fr) * 1985-08-22 1987-02-26 Commonwealth Scientific And Industrial Research Or Analogues peptidiques du facteur de croissance 1 similaire a l'insuline chez les mammiferes
AU613876B2 (en) * 1986-10-01 1991-08-15 Merck & Co., Inc. Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices
JPH01144981A (ja) * 1987-12-02 1989-06-07 Wakunaga Pharmaceut Co Ltd 蛋白質の製造
WO1989005822A1 (fr) * 1987-12-24 1989-06-29 Gropep Pty. Ltd. Analogues peptidiques du facteur 1 (igf-1) ou du facteur 2 (igf-2) de croissance similaire a l'insuline

Also Published As

Publication number Publication date
WO1990015142A1 (fr) 1990-12-13
DE69021335D1 (de) 1995-09-07
DE69021335T2 (de) 1996-04-11
EP0429586A4 (en) 1992-07-08
EP0429586B1 (fr) 1995-08-02
US5330971A (en) 1994-07-19
ATE125869T1 (de) 1995-08-15
EP0429586A1 (fr) 1991-06-05
CA2033176C (fr) 1999-12-14

Similar Documents

Publication Publication Date Title
CA2033176A1 (fr) Proteines de fusion d'hormones de croissance
EP0161640A3 (fr) Cellules de souris enkystées et transformées avec l'ADN rétrovirus aviaire-hormone de croissance bovine et un procédé pour administrer la BGH in vivo
IE811463L (en) Interferons
NZ227788A (en) Peptide having growth hormone regulatory effects, and compositions
HK1005594A1 (en) Interleukin-4 protein having bcgf and tcgf activity on human cells (human interleukin-4)
IL96723A0 (en) Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof
AU7681687A (en) Expression of platelet-derived growth factor and analogues
AU601959B2 (en) GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use
WO2000034474A3 (fr) Zvegf3 homologue du facteur de croissance
AU2308992A (en) Cysteine depleted il-6 muteins
EP0181634A3 (fr) Gène synthétique pour lysozyme humaine
IE871871L (en) Cloning and expression of acidic fibroblast growth factor
NZ235743A (en) Food additives promoting ice nucleation containing proteins carried by gras microorganisms, plasmids and recombinant host cells
EP0232107A3 (fr) Dérivé du polypeptide de la lymphotoxine humaine
EP0315118A3 (fr) ADN codant pour endothéline et son utilisant
AU590861B2 (en) New human lymphotoxin (TNF-beta) polypeptides their prepartion and use
JPS6420086A (en) Polypeptide and production thereof
SE9403055D0 (sv) A new human peptide antibiotic (FALL-39) and its use
MY100892A (en) Veterinary preparations.
AU2140695A (en) Recombinant viruses coding for a glutamate decarboxylase (gad) activity
CA2004764A1 (fr) Proteines ancrod, leur preparation et leur utilisation
高亚胜 et al. A PRIMARY OBSERVATION OF TPA EFFECT ON SSV-NIH3T3 CELLS IN SERUM-FREE MEDIUM
CA2236679A1 (fr) Polypeptide suppresseur et de differenciation
NO941982L (no) Fremstilling av proteiner ved anvendelse av 7B2 protein
Bukhalo et al. Identification of the strain Polyporus squamosus Huds. ex Fr. PS-64 to be used as a producer of food biomass, as Fusarium sambucinum var. ossicolum(Berk. and Curt.).

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry