CA2032475A1 - Preparations pharmaceutiques pour administration par voie orale permettant la liberation du medicament dans des endroits cibles de l'intestin - Google Patents

Preparations pharmaceutiques pour administration par voie orale permettant la liberation du medicament dans des endroits cibles de l'intestin

Info

Publication number
CA2032475A1
CA2032475A1 CA2032475A CA2032475A CA2032475A1 CA 2032475 A1 CA2032475 A1 CA 2032475A1 CA 2032475 A CA2032475 A CA 2032475A CA 2032475 A CA2032475 A CA 2032475A CA 2032475 A1 CA2032475 A1 CA 2032475A1
Authority
CA
Canada
Prior art keywords
release
component
intestine
core
intestines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2032475A
Other languages
English (en)
Other versions
CA2032475C (fr
Inventor
Heiji Ikushima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2032475A1 publication Critical patent/CA2032475A1/fr
Application granted granted Critical
Publication of CA2032475C publication Critical patent/CA2032475C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Préparation pharmaceutique améliorée pour administration orale, adaptée pour libérer le médicament dans des sites particuliers de l'intestin. La préparation comprend un noyau contenant un ingrédient actif et un excipient de qualité pharmaceutique acceptable; une première couche recouvrant ce noyau, composée d'un ingrédient kératinisé ou hydrosoluble et un ingrédient facultatif insoluble; une seconde couche recouvrant la première, composée d'un ingrédient non kératinisé qui se dissout en réagissant avec au moins un ingrédient contenu dans le noyau; et une troisième couche recouvrant la seconde, composée d'un ingrédient kératinisé. Cette préparation se caractérise, d'une part, en ce qu'elle ne libère pas l'ingrédient actif tant qu'elle n'a pas atteint un site choisi dans l'intestin et, d'autre part, en ce qu'elle peut contrôler la vitesse à laquelle l'ingrédient actif est libéré après avoir atteint le site choisi. Elle est donc particulièrement efficace pour administrer des ingrédients actifs ayant une spécificité d'absorption à des sites particuliers de l'intestin ou pour traiter des maladies situées dans des sites particuliers de l'intestin.
CA002032475A 1989-05-11 1990-05-10 Preparations pharmaceutiques pour administration par voie orale permettant la liberation du medicament dans des endroits cibles de l'intestin Expired - Lifetime CA2032475C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP116086/1989 1989-05-11
JP11608689 1989-05-11

Publications (2)

Publication Number Publication Date
CA2032475A1 true CA2032475A1 (fr) 1990-11-12
CA2032475C CA2032475C (fr) 1997-12-30

Family

ID=14678366

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002032475A Expired - Lifetime CA2032475C (fr) 1989-05-11 1990-05-10 Preparations pharmaceutiques pour administration par voie orale permettant la liberation du medicament dans des endroits cibles de l'intestin

Country Status (8)

Country Link
EP (1) EP0425699B1 (fr)
JP (1) JP2967492B2 (fr)
AT (1) ATE109973T1 (fr)
CA (1) CA2032475C (fr)
DE (1) DE69011618T2 (fr)
DK (1) DK0425699T3 (fr)
ES (1) ES2062527T3 (fr)
WO (1) WO1990013286A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2137265C (fr) * 1992-06-04 2003-10-28 Sanjay Bhardwaj Compositions pharmaceutiques de gout agreable
PT621032E (pt) * 1993-04-23 2001-01-31 Novartis Ag Dispositivo de distribuicao de libertacao controlada de farmaco
US5447729A (en) * 1994-04-07 1995-09-05 Pharmavene, Inc. Multilamellar drug delivery systems
GB9412394D0 (en) 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
JP3185206B2 (ja) * 1995-07-20 2001-07-09 田辺製薬株式会社 消化管下部放出型被覆カプセル製剤
SG80553A1 (en) * 1995-07-20 2001-05-22 Tanabe Seiyaku Co Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract
JPH10152431A (ja) * 1996-08-02 1998-06-09 Hisamitsu Pharmaceut Co Inc 経口製剤用カプセルと経口カプセル製剤
JP3950175B2 (ja) * 1997-05-30 2007-07-25 オスモティカ・コーポレイション 多層浸透デバイス
WO2000006128A1 (fr) 1998-07-28 2000-02-10 Tanabe Seiyaku Co., Ltd. Preparation capable de liberer un medicament au niveau d'un site cible dans l'intestin
JP2003201256A (ja) * 2001-12-28 2003-07-18 Hisamitsu Pharmaceut Co Inc 大腸送達性経口医薬製剤、大腸癌治療用経口医薬製剤および大腸炎治療用経口医薬製剤
JP4694145B2 (ja) * 2004-05-17 2011-06-08 株式会社 メドレックス 経口腸溶性製剤
US20060280795A1 (en) * 2005-06-08 2006-12-14 Dexcel Pharma Technologies, Ltd. Specific time-delayed burst profile delivery system
JPWO2008117814A1 (ja) 2007-03-26 2010-07-15 帝國製薬株式会社 大腸送達用経口製剤
JP2014529630A (ja) * 2011-09-07 2014-11-13 ザウラー−ブロシュ、ローラント 哺乳類の消化管における一つあるいは複数の物質の放出制御製剤
WO2017115745A1 (fr) * 2015-12-28 2017-07-06 エスエス製薬株式会社 Préparation pharmaceutique obtenue par moulage par compression

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471186A1 (fr) * 1979-12-10 1981-06-19 Roussel Uclaf Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation
GB8518301D0 (en) * 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
DE3812799A1 (de) * 1988-04-16 1989-10-26 Sanol Arznei Schwarz Gmbh Oral zu verabreichende pharmazeutische zubereitung mit kontrollierter wirkstofffreisetzung und verfahren zu deren herstellung
IT1230576B (it) * 1988-10-20 1991-10-28 Angeli Inst Spa Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon

Also Published As

Publication number Publication date
EP0425699B1 (fr) 1994-08-17
EP0425699A4 (en) 1991-11-13
ES2062527T3 (es) 1994-12-16
WO1990013286A1 (fr) 1990-11-15
EP0425699A1 (fr) 1991-05-08
JPH0372417A (ja) 1991-03-27
JP2967492B2 (ja) 1999-10-25
CA2032475C (fr) 1997-12-30
DE69011618D1 (de) 1994-09-22
DE69011618T2 (de) 1994-12-15
DK0425699T3 (da) 1994-11-21
ATE109973T1 (de) 1994-09-15

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