CA2012208C - Methode de traitement de la periodontite - Google Patents
Methode de traitement de la periodontite Download PDFInfo
- Publication number
- CA2012208C CA2012208C CA 2012208 CA2012208A CA2012208C CA 2012208 C CA2012208 C CA 2012208C CA 2012208 CA2012208 CA 2012208 CA 2012208 A CA2012208 A CA 2012208A CA 2012208 C CA2012208 C CA 2012208C
- Authority
- CA
- Canada
- Prior art keywords
- composition
- use according
- retinoid
- topical
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000001245 periodontitis Diseases 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title abstract description 20
- 230000000699 topical effect Effects 0.000 claims abstract description 25
- -1 retinoid compound Chemical group 0.000 claims abstract description 16
- 230000009885 systemic effect Effects 0.000 claims abstract description 9
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims abstract description 8
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims abstract description 8
- HQMNCQVAMBCHCO-DJRRULDNSA-N etretinate Chemical compound CCOC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C=C(OC)C(C)=C1C HQMNCQVAMBCHCO-DJRRULDNSA-N 0.000 claims abstract description 8
- 229960002199 etretinate Drugs 0.000 claims abstract description 8
- 229960005280 isotretinoin Drugs 0.000 claims abstract description 8
- 235000020945 retinal Nutrition 0.000 claims abstract description 6
- 239000011604 retinal Substances 0.000 claims abstract description 6
- 229930002330 retinoic acid Natural products 0.000 claims abstract description 6
- NCYCYZXNIZJOKI-OVSJKPMPSA-N Retinaldehyde Chemical compound O=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 claims abstract description 5
- 229960005339 acitretin Drugs 0.000 claims abstract description 5
- IHUNBGSDBOWDMA-AQFIFDHZSA-N all-trans-acitretin Chemical compound COC1=CC(C)=C(\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O)C(C)=C1C IHUNBGSDBOWDMA-AQFIFDHZSA-N 0.000 claims abstract description 5
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 150000004370 vitamin A ester derivatives Chemical class 0.000 claims abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 38
- 230000003239 periodontal effect Effects 0.000 claims description 12
- 150000004492 retinoid derivatives Chemical class 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 4
- 230000037396 body weight Effects 0.000 claims description 3
- 239000007894 caplet Substances 0.000 claims description 3
- 229940112822 chewing gum Drugs 0.000 claims description 3
- 235000015218 chewing gum Nutrition 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000007937 lozenge Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000000606 toothpaste Substances 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 239000006193 liquid solution Substances 0.000 claims 2
- 229940034610 toothpaste Drugs 0.000 claims 2
- 238000011282 treatment Methods 0.000 abstract description 20
- 210000001519 tissue Anatomy 0.000 description 17
- 208000028169 periodontal disease Diseases 0.000 description 12
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000003981 vehicle Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 208000007565 gingivitis Diseases 0.000 description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 5
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 5
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 5
- 235000019155 vitamin A Nutrition 0.000 description 5
- 239000011719 vitamin A Substances 0.000 description 5
- 229940045997 vitamin a Drugs 0.000 description 5
- 208000005888 Periodontal Pocket Diseases 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 239000004098 Tetracycline Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 235000019364 tetracycline Nutrition 0.000 description 3
- 150000003522 tetracyclines Chemical class 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 229960001727 tretinoin Drugs 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000006186 oral dosage form Substances 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 210000002379 periodontal ligament Anatomy 0.000 description 2
- 210000004261 periodontium Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229940040944 tetracyclines Drugs 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
- 239000000006 Nitroglycerin Substances 0.000 description 1
- 208000004179 Oral Leukoplakia Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940003587 aquaphor Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 210000004513 dentition Anatomy 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 230000001329 hyperkeratotic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 201000011486 lichen planus Diseases 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 229940067003 orabase Drugs 0.000 description 1
- 229940124624 oral corticosteroid Drugs 0.000 description 1
- 201000008557 oral mucosa leukoplakia Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 230000036346 tooth eruption Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32934289A | 1989-03-27 | 1989-03-27 | |
| US329,342 | 1989-03-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2012208A1 CA2012208A1 (fr) | 1990-09-27 |
| CA2012208C true CA2012208C (fr) | 2001-05-22 |
Family
ID=23284942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2012208 Expired - Fee Related CA2012208C (fr) | 1989-03-27 | 1990-03-15 | Methode de traitement de la periodontite |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2012208C (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004093995A3 (fr) * | 2003-04-17 | 2005-04-21 | St Georges Entpr Ltd | Utilisation d'antioxydants pour traiter les troubles associes a la perte osseuse |
-
1990
- 1990-03-15 CA CA 2012208 patent/CA2012208C/fr not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004093995A3 (fr) * | 2003-04-17 | 2005-04-21 | St Georges Entpr Ltd | Utilisation d'antioxydants pour traiter les troubles associes a la perte osseuse |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2012208A1 (fr) | 1990-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2005322191B2 (en) | Method of reducing oral tissue inflammation using magnolia extract | |
| US5512278A (en) | Ointment base useful for pharmaceutical preparations | |
| EP0137668B1 (fr) | Ibuprofen, flurbiprofen et leur utilisation en thérapeutique | |
| CA2948409C (fr) | Compositions orales ameliorees comprenant du citrate de zinc et/ou des agents tocopherol | |
| US5188817A (en) | Method of treatment for periodontitis | |
| WO1996003149A9 (fr) | Compositions fongicides et cicatrisantes et procedes de preparation et d'utilisation | |
| EP0773795A1 (fr) | Compositions fongicides et cicatrisantes et procedes de preparation et d'utilisation | |
| WO2008042944A2 (fr) | Formulations pour soin oral non irritantes | |
| CA2523000A1 (fr) | Methodes et produits de soins buccaux | |
| US20070098650A1 (en) | Dental formulation | |
| US20120328537A1 (en) | Topical wound management formulation | |
| US5167952A (en) | Therapeutic composition formulated as a dental rinse that stimulates Prostaglandin synthesis in the mouth to prevent plaque buildup on the teeth and Periodontal disease | |
| CA2012208C (fr) | Methode de traitement de la periodontite | |
| US4985235A (en) | Treatment of periodontoclasia with retinoic acid | |
| US20100129295A1 (en) | Compositions for preventing and/or treating gingivitis | |
| JP2001089383A (ja) | 口腔用及び眼科用組成物 | |
| CN101132806A (zh) | 使用木兰提取物减少口腔组织炎症的方法 | |
| JPS6296408A (ja) | 口腔用薬剤 | |
| JPH08133969A (ja) | 歯槽骨吸収抑制剤 | |
| JPH02500189A (ja) | イブプロフェンまたはフルルビプロフェンを用いる歯肉炎の治療 | |
| US20180085374A1 (en) | Use of Morpholino Compounds for the Treatment of Halitosis | |
| WO2022204731A1 (fr) | Produit de soins buccaux à composés cannabinoïdes | |
| CA1337931C (fr) | Traitement de la parodontose avec de l'acide retinoique | |
| JPS61293909A (ja) | 口腔内組成物 | |
| EP0228137B1 (fr) | Composition antibactérienne sélective pour anaérobes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |