CA2012096A1 - Cytosine compounds and a process for the production thereof - Google Patents

Cytosine compounds and a process for the production thereof

Info

Publication number
CA2012096A1
CA2012096A1 CA 2012096 CA2012096A CA2012096A1 CA 2012096 A1 CA2012096 A1 CA 2012096A1 CA 2012096 CA2012096 CA 2012096 CA 2012096 A CA2012096 A CA 2012096A CA 2012096 A1 CA2012096 A1 CA 2012096A1
Authority
CA
Canada
Prior art keywords
group
formula
compounds
compound
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2012096
Other languages
French (fr)
Other versions
CA2012096C (en
Inventor
Khashayar Karimian
Bruno Konrad Radatus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Pharmachem Inc
Original Assignee
Acic Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA 2012096 priority Critical patent/CA2012096C/en
Application filed by Acic Canada Inc filed Critical Acic Canada Inc
Priority to DE69111438T priority patent/DE69111438T2/en
Priority to BR919106157A priority patent/BR9106157A/en
Priority to AU74801/91A priority patent/AU7480191A/en
Priority to EP91906308A priority patent/EP0523080B1/en
Priority to PCT/CA1991/000078 priority patent/WO1991013901A1/en
Priority to HU9202905A priority patent/HUT61565A/en
Priority to US07/930,605 priority patent/US5399682A/en
Priority to AT91906308T priority patent/ATE125265T1/en
Publication of CA2012096A1 publication Critical patent/CA2012096A1/en
Priority to US08/191,192 priority patent/US5527782A/en
Priority to US08/356,498 priority patent/US5536824A/en
Priority to US08/469,506 priority patent/US5596093A/en
Application granted granted Critical
Publication of CA2012096C publication Critical patent/CA2012096C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Saccharide Compounds (AREA)

Abstract

Compounds of Formula I:

(see fig. I) wherein R1 is selected from the group comprising a trifluoromethyl group, a C1-C6 alkyl group and a C6-C9 aryl group, and R2 is selected from the group comprising hydrogen, trityl, methoxytrityl, dimethoxytrityl, acetyl, a C2-C6 alkylacyl group, a C6-C9 arylacyl group, allyl, 2,2,2-trichloroethyl, phosphates and salts thereof, tosyl and mesyl, and a process for the production thereof are provided. The compound of Formula I or the corresponding pharmaceutically acceptable salt (or the neutral form of the compound of Formula I) may then be converted to the corresponding compound of Formula V, or pharmaceutically acceptable salts thereof:
(see fig. V) wherein R2 is as defined above. Compounds of Formula I
and V are useful for inhibition of DNA synthesis.
CA 2012096 1990-03-13 1990-03-13 Cytosine compounds and a process for the production thereof Expired - Lifetime CA2012096C (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CA 2012096 CA2012096C (en) 1990-03-13 1990-03-13 Cytosine compounds and a process for the production thereof
AT91906308T ATE125265T1 (en) 1990-03-13 1991-03-13 2,3'-O-CYCLOCYTIDINES AND METHOD FOR THE PRODUCTION THEREOF.
AU74801/91A AU7480191A (en) 1990-03-13 1991-03-13 3'-o-tosylcytidine and cytosine compounds, and process for production thereof
EP91906308A EP0523080B1 (en) 1990-03-13 1991-03-13 2,3'-o-cyclocytidines, and process for production thereof
PCT/CA1991/000078 WO1991013901A1 (en) 1990-03-13 1991-03-13 3'-o-tosylcytidine and cytosine compounds, and process for production thereof
HU9202905A HUT61565A (en) 1990-03-13 1991-03-13 Process for producing 2,3'-0-cyclocytidine and 1-(beta-d-xylopento-furanosyl)-cytosine derivatives and their analogous compounds, as well as 3'-0-(p-toluenesulfonyl)-cytidine derivatives
DE69111438T DE69111438T2 (en) 1990-03-13 1991-03-13 2,3'-O-CYCLOCYTIDINE AND METHOD FOR THE PRODUCTION THEREOF.
BR919106157A BR9106157A (en) 1990-03-13 1991-03-13 COMPOUNDS AND PROCESS 3'-O-TOSIL CYTIDINE AND CYTOSINE AND PROCESS FOR THE PRODUCTION OF THE SAME
US07/930,605 US5399682A (en) 1990-03-13 1991-03-13 Process for preparing 2,3'-O-cyclocytidine
US08/191,192 US5527782A (en) 1990-03-13 1994-02-02 5-halo-2,3'-O-cyclocytidines
US08/356,498 US5536824A (en) 1990-03-13 1994-12-15 Organosulfonyl salts of 2,3'-O-cyclocytidine
US08/469,506 US5596093A (en) 1990-03-13 1995-06-06 Process for preparing halogenated 2,3-O-cyclocytidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2012096 CA2012096C (en) 1990-03-13 1990-03-13 Cytosine compounds and a process for the production thereof

Publications (2)

Publication Number Publication Date
CA2012096A1 true CA2012096A1 (en) 1991-09-13
CA2012096C CA2012096C (en) 1997-10-28

Family

ID=4144518

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2012096 Expired - Lifetime CA2012096C (en) 1990-03-13 1990-03-13 Cytosine compounds and a process for the production thereof

Country Status (1)

Country Link
CA (1) CA2012096C (en)

Also Published As

Publication number Publication date
CA2012096C (en) 1997-10-28

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