SE8303565L - PROCEDURE FOR THE PREPARATION OF 1-ALKYL OR 1,4-DIALKYL-1H-PYRROL-2-ETHYAC ACID ESTERS - Google Patents

PROCEDURE FOR THE PREPARATION OF 1-ALKYL OR 1,4-DIALKYL-1H-PYRROL-2-ETHYAC ACID ESTERS

Info

Publication number
SE8303565L
SE8303565L SE8303565A SE8303565A SE8303565L SE 8303565 L SE8303565 L SE 8303565L SE 8303565 A SE8303565 A SE 8303565A SE 8303565 A SE8303565 A SE 8303565A SE 8303565 L SE8303565 L SE 8303565L
Authority
SE
Sweden
Prior art keywords
alkyl
dialkyl
preparation
general formula
acid esters
Prior art date
Application number
SE8303565A
Other languages
Swedish (sv)
Other versions
SE8303565D0 (en
SE454441B (en
Inventor
E Agai
K Harsanyi
G Domany
P Major
K Molnar
M Szollosy
A Kruzics
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8303565D0 publication Critical patent/SE8303565D0/en
Publication of SE8303565L publication Critical patent/SE8303565L/en
Publication of SE454441B publication Critical patent/SE454441B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to a new process for the preparation of 1-alkyl- or 1,4-dialkyl-1H-pyrrole- -2-acetic acid, esters of the general formula (I) < IMG > (I) wherein R1 is hydrogen or an alkyl group having from 1 to 4 carbon atoms, R2 and R3 each independently represent an alkyl group having from 1 to 4 carbon atoms, by selective desalkoxycarbonylation of the corresponding 1-alkyl- and 1,4-dialkyl-3-alkoxycarbonyl-1H-pyrrole- -2-acetic acid esters of the general formula (II) < IMG > (II) wherein R1, R2 and R3 have the same meaning as defined above, by heating in the presence of a concentrated mineral acid or an aliphatic or aromatic sulfonic acid. Compounds of the general formula (I) are known pharmaceutically active materials, which can be prepared by this process in a single reaction step selectively, without the formation of by-products.
SE8303565A 1982-06-22 1983-06-21 PROCEDURE FOR THE PREPARATION OF 1-ALKYL OR 1,4-DIALKYL-1H-PYRROL-2-ETHIC ACID ESTERS SE454441B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU822013A HU187137B (en) 1982-06-22 1982-06-22 Process for producing esters of 1-alkyl- orl,4-dialkyl-1h-pyrrol-acetic acid

Publications (3)

Publication Number Publication Date
SE8303565D0 SE8303565D0 (en) 1983-06-21
SE8303565L true SE8303565L (en) 1983-12-23
SE454441B SE454441B (en) 1988-05-02

Family

ID=10957298

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8303565A SE454441B (en) 1982-06-22 1983-06-21 PROCEDURE FOR THE PREPARATION OF 1-ALKYL OR 1,4-DIALKYL-1H-PYRROL-2-ETHIC ACID ESTERS

Country Status (10)

Country Link
JP (1) JPS597162A (en)
AT (1) AT377255B (en)
CA (1) CA1188306A (en)
DK (1) DK287183A (en)
ES (1) ES8500227A1 (en)
FI (1) FI77023C (en)
HU (1) HU187137B (en)
IN (1) IN160016B (en)
SE (1) SE454441B (en)
SU (1) SU1179921A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987002662A2 (en) * 1985-10-25 1987-05-07 Sandoz Ag Heterocyclic analogs of mevalonolactone and derivatives thereof, processes for their production and their use as pharmaceuticals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3752826A (en) * 1970-01-26 1973-08-14 Mcneilab Inc Aroyl substituted pyrroles

Also Published As

Publication number Publication date
SE8303565D0 (en) 1983-06-21
IN160016B (en) 1987-06-20
HU187137B (en) 1985-11-28
AT377255B (en) 1985-02-25
ES523478A0 (en) 1984-10-01
JPH0136825B2 (en) 1989-08-02
DK287183D0 (en) 1983-06-21
FI77023B (en) 1988-09-30
ATA228383A (en) 1984-07-15
ES8500227A1 (en) 1984-10-01
SE454441B (en) 1988-05-02
FI832262L (en) 1983-12-23
FI77023C (en) 1989-01-10
DK287183A (en) 1983-12-23
JPS597162A (en) 1984-01-14
SU1179921A3 (en) 1985-09-15
CA1188306A (en) 1985-06-04
FI832262A0 (en) 1983-06-21

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