KR860000278A - Method for preparing tetrahydro-β-carboline derivative - Google Patents

Method for preparing tetrahydro-β-carboline derivative Download PDF

Info

Publication number
KR860000278A
KR860000278A KR1019850003845A KR850003845A KR860000278A KR 860000278 A KR860000278 A KR 860000278A KR 1019850003845 A KR1019850003845 A KR 1019850003845A KR 850003845 A KR850003845 A KR 850003845A KR 860000278 A KR860000278 A KR 860000278A
Authority
KR
South Korea
Prior art keywords
formula
compound
lower alkyl
hydrogen
carboxy
Prior art date
Application number
KR1019850003845A
Other languages
Korean (ko)
Inventor
이꾸오 이이지마 (외 4)
Original Assignee
마쓰바라 이찌로
다나베 세이야꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 마쓰바라 이찌로, 다나베 세이야꾸 가부시끼 가이샤 filed Critical 마쓰바라 이찌로
Publication of KR860000278A publication Critical patent/KR860000278A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

테르라히드로-β-카르볼린 유도체의 제조방법Method for preparing terahydro-β-carboline derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

a)다음식(Ⅰ)의 화합물(Ⅰ)을 얻기위헤 다음식(Ⅱ)의 화합물을 반응시키거나; 또는 b) 다음식(Ⅰ-d)의 화합물을 얻기위해 다음식(Ⅳ)의 화합물과 디아조-저급알칸; 저급알카노산 또는 그의 반응성 유도체; 및 불포화된 산소-함유 모노시클릭헤테로고리 화합물로 구성되는 기로부터 선택된 화합물을 반응시키고; 및 c) 필요하다면, 그의 염으로 전환시킴을 특징으로하는 다음식(Ⅰ)의 화합물의 제조방법a) reacting the compound of formula (II) to obtain compound (I) of formula (I); Or b) a compound of formula (IV) and a diazo-lower alkane to obtain a compound of formula (I-d); Lower alkanoic acid or reactive derivatives thereof; And a compound selected from the group consisting of unsaturated oxygen-containing monocyclic heterocyclic compounds; And c) a process for the preparation of a compound of formula (I) characterized by conversion to salts thereof, if necessary (Ⅰ) (Ⅰ) 상기 식에서 R2는 저급알킬이고, 및 A) R1늠 히드록시메틸 또는 카르복시이고,R3및 R4는 모두 수소이고, X는 할로겐, 저급알킬, 저급알콕시, 히드록시 또는 벤질옥시이거나, 또는 B) R1은 수소, 카르복시-저급알킬 또는 식; -CH2OY(식중, Y는 저급알킬, 저급알카노일 또는 산소함유 모노시클릭헤테로고리기임)의 기이고, R3는 수소, 히드록시-저급알킬 또는 카르복시이고, R4는 수소 또는 히드록시-저급알킬이고 및 X는 수소이다.Wherein R 2 is lower alkyl, and A) R 1 is hydroxymethyl or carboxy, R 3 and R 4 are both hydrogen, X is halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy, or B) R 1 is hydrogen, carboxy-loweralkyl or a formula; -CH 2 OY, wherein Y is a lower alkyl, lower alkanoyl or oxygen-containing monocyclic heterocyclic group, R 3 is hydrogen, hydroxy-lower alkyl or carboxy, and R 4 is hydrogen or hydroxy Lower alkyl and X is hydrogen. (Ⅱ) (Ⅱ) 상기 식에서 R1,R3,R4및 X는 상기에 정의한 바와 같다.Wherein R 1 , R 3 , R 4 and X are as defined above. R2-X1(Ⅲ)R 2 -X 1 (III) 상기 식에서 X1은 할로겐이고, R2는 상기에 정의한 바와 같다.Wherein X 1 is halogen and R 2 is as defined above. (Ⅳ) (Ⅳ) 상기 식에서 R2는 상기에 정의한 바와 같다.Wherein R 2 is as defined above. (Ⅰ-d) (I-d) 상기 식에서 Y눈 저급알킬, 저급알카노일 또는 산소함유모노시클릭 헤테로고리기이다.Y is lower alkyl, lower alkanoyl or oxygen-containing monocyclic heterocyclic group. ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850003845A 1984-06-06 1985-06-01 Method for preparing tetrahydro-β-carboline derivative KR860000278A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB84/14409 1984-06-06
GB848414409A GB8414409D0 (en) 1984-06-06 1984-06-06 Tetrahydro-beta-carboline derivative

Publications (1)

Publication Number Publication Date
KR860000278A true KR860000278A (en) 1986-01-27

Family

ID=10562001

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003845A KR860000278A (en) 1984-06-06 1985-06-01 Method for preparing tetrahydro-β-carboline derivative

Country Status (3)

Country Link
KR (1) KR860000278A (en)
CN (1) CN85104455A (en)
GB (1) GB8414409D0 (en)

Also Published As

Publication number Publication date
CN85104455A (en) 1986-12-10
GB8414409D0 (en) 1984-07-11

Similar Documents

Publication Publication Date Title
US4110381A (en) 2-Decarboxy-2-hydroxy-methyl-3,7-inter-m-phenylene-ω-phenoxy-PGF.sub.1
KR840001156A (en) Method for preparing benzimidazole derivatives
KR850000033A (en) Method for preparing 8-chloro-1,5-benzothiazepine derivative
KR850001199A (en) Preparation of 1,8-naphthyridine derivative
US3914282A (en) Prostaglandin E{HD 1{B , F{HD 1{B , and A{HD 1 {B analogs
KR850004754A (en) Method for producing 3-indole carboxamide compounds
KR840003628A (en) Method for preparing pyridyl compound
KR830007626A (en) Method for producing 2- (1,4-benzodioxan-2-ylalkyl) imidazole
US4139564A (en) 2-Decarboxy-2-hydroxymethyl)-16-fluoro-PGE2 compounds
US4088690A (en) 2-Decarboxy-2-hydroxymethyl-cis-4,5-didehydro-9-deoxy-9,10-didehydro-PGD1 compounds
IE792329L (en) Thiazaheterocyclics and process for preparing pyrrolidine¹and piperidine derivatives.
KR870006082A (en) Method for preparing 10β-alkynylestrene derivative
KR860000278A (en) Method for preparing tetrahydro-β-carboline derivative
KR840000530A (en) Method for preparing new benzotriazole
KR830006265A (en) Method for preparing heterocyclic compound
US4138590A (en) Prostaglandin derivatives
EP0206765A3 (en) Process for preparation of rooperol, hypoxoside and derivatives thereof
KR850006177A (en) Method for preparing cinnamic acid derivatives
KR860004051A (en) Method for preparing substituted phenylpiperazine derivatives
US4208538A (en) 2-Decarboxy-2-hydroxymethyl-3,7-inter-m-phenylene-ω-phenyl-PGF2 compounds
KR870003114A (en) Tetrahydroisoquinoline derivatives
US4267395A (en) 2-Decarboxy-2-hydroxymethyl-19-hydroxy-19-methyl-6A-carba-PGI2 compounds
ES8608538A1 (en) Process for the preparation of alfa-L-aspartyl-L-phenylalanine alkyl esters.
KR850006393A (en) Process for preparing piperazinyl derivatives of quinoline carboxylic acids
KR850006397A (en) Method for preparing substituted isochromans and oxepins

Legal Events

Date Code Title Description
SUBM Submission of document of abandonment before or after decision of registration