CA2007740A1 - Acides quinolinecarboxylique substitue - Google Patents
Acides quinolinecarboxylique substitueInfo
- Publication number
- CA2007740A1 CA2007740A1 CA2007740A CA2007740A CA2007740A1 CA 2007740 A1 CA2007740 A1 CA 2007740A1 CA 2007740 A CA2007740 A CA 2007740A CA 2007740 A CA2007740 A CA 2007740A CA 2007740 A1 CA2007740 A1 CA 2007740A1
- Authority
- CA
- Canada
- Prior art keywords
- quinolinecarboxylic acids
- substituted
- substituted quinolinecarboxylic
- disclosed
- arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title abstract 2
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 230000002917 arthritic effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/298,585 | 1989-01-17 | ||
US07/298,585 US4968702A (en) | 1989-01-17 | 1989-01-17 | Substituted quinolinecarboxylic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2007740A1 true CA2007740A1 (fr) | 1990-07-17 |
CA2007740C CA2007740C (fr) | 1999-12-07 |
Family
ID=23151154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002007740A Expired - Lifetime CA2007740C (fr) | 1989-01-17 | 1990-01-15 | Acides quinolinecarboxylique substitue |
Country Status (17)
Country | Link |
---|---|
US (1) | US4968702A (fr) |
EP (1) | EP0379145B1 (fr) |
JP (1) | JP3004025B2 (fr) |
KR (1) | KR0140076B1 (fr) |
AT (1) | ATE152711T1 (fr) |
AU (1) | AU624471B2 (fr) |
CA (1) | CA2007740C (fr) |
DE (1) | DE69030632T2 (fr) |
DK (1) | DK0379145T3 (fr) |
ES (1) | ES2100851T3 (fr) |
GR (1) | GR3023585T3 (fr) |
HK (1) | HK1008019A1 (fr) |
IE (1) | IE900169L (fr) |
IL (1) | IL92898A (fr) |
NZ (1) | NZ232111A (fr) |
PH (1) | PH26961A (fr) |
ZA (1) | ZA90299B (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5310732A (en) * | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
US5409886A (en) * | 1993-02-18 | 1995-04-25 | Mitsui Toatsu Chemicals, Incorporated | 3-pyrroline-2-one derivatives and herbicidal compositions containing same |
US5393891A (en) * | 1993-06-08 | 1995-02-28 | The Du Pont Merck Pharmaceutical Company | Immunoassay reagents and methods for detecting brequinar and analogs |
US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
US5453431A (en) * | 1993-10-29 | 1995-09-26 | Gilman; Andrew L. | Use of hydroxychloroquine for treatment of graft-versus-host disease |
US5578609A (en) * | 1994-03-25 | 1996-11-26 | The Dupont Merck Pharmaceutical Company | 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents |
AU757059B2 (en) | 1997-06-19 | 2003-01-30 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
US6207679B1 (en) | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
US6376670B1 (en) | 1997-06-19 | 2002-04-23 | Sepracor Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
WO1999038846A1 (fr) * | 1998-01-30 | 1999-08-05 | Procept, Inc. | Agents immunosuppresseurs |
AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
AR037233A1 (es) | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
AR036873A1 (es) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
MXPA05001642A (es) * | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de naftaleno como inhibidores de metaloproteinasas de matriz. |
US7138412B2 (en) * | 2003-03-11 | 2006-11-21 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives useful as serine protease inhibitors |
WO2006115509A2 (fr) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence |
CA2898615A1 (fr) * | 2013-01-28 | 2014-07-31 | Viamet Pharmaceuticals, Inc. | Composes inhibiteurs de metalloenzyme |
KR20160079123A (ko) | 2013-11-22 | 2016-07-05 | 젠자임 코포레이션 | 신경변성 질병을 치료하기 위한 신규한 방법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE287804C (fr) * | ||||
US2888346A (en) * | 1955-08-22 | 1959-05-26 | Gen Aniline & Film Corp | Ultra-violet absorbing compounds |
FR2166297A1 (en) * | 1972-01-07 | 1973-08-17 | Rosenberg Eli | 2-(4-isopropylphenyl)quinoline-4-carboxylic acid - as a non-toxic, analgesic agent |
US4680299A (en) * | 1984-04-30 | 1987-07-14 | E.I. Du Pont De Nemours And Company | 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof |
EP0133244B1 (fr) * | 1983-07-22 | 1990-12-05 | E.I. Du Pont De Nemours And Company | Acides phénylquinolinecarboxyliques et dérivés comme agents antitumoraux |
EP0318093A3 (fr) * | 1987-11-25 | 1990-12-05 | Merck Frosst Canada Inc. | Acides dicarboxyliques des diaryl quinoléines et leur utilisation comme médicaments |
-
1989
- 1989-01-17 US US07/298,585 patent/US4968702A/en not_active Expired - Lifetime
- 1989-12-27 IL IL9289889A patent/IL92898A/en unknown
-
1990
- 1990-01-08 PH PH39858A patent/PH26961A/en unknown
- 1990-01-15 CA CA002007740A patent/CA2007740C/fr not_active Expired - Lifetime
- 1990-01-15 NZ NZ232111A patent/NZ232111A/en unknown
- 1990-01-16 AU AU48502/90A patent/AU624471B2/en not_active Ceased
- 1990-01-16 ES ES90100839T patent/ES2100851T3/es not_active Expired - Lifetime
- 1990-01-16 KR KR1019900000643A patent/KR0140076B1/ko not_active IP Right Cessation
- 1990-01-16 DE DE69030632T patent/DE69030632T2/de not_active Expired - Fee Related
- 1990-01-16 EP EP90100839A patent/EP0379145B1/fr not_active Expired - Lifetime
- 1990-01-16 JP JP2004637A patent/JP3004025B2/ja not_active Expired - Fee Related
- 1990-01-16 ZA ZA90299A patent/ZA90299B/xx unknown
- 1990-01-16 DK DK90100839.1T patent/DK0379145T3/da active
- 1990-01-16 AT AT90100839T patent/ATE152711T1/de not_active IP Right Cessation
- 1990-01-16 IE IE900169A patent/IE900169L/xx not_active IP Right Cessation
-
1997
- 1997-05-30 GR GR950401502T patent/GR3023585T3/el unknown
-
1998
- 1998-06-27 HK HK98107244A patent/HK1008019A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL92898A0 (en) | 1990-09-17 |
PH26961A (en) | 1992-12-28 |
KR900011733A (ko) | 1990-08-02 |
JP3004025B2 (ja) | 2000-01-31 |
DE69030632D1 (de) | 1997-06-12 |
GR3023585T3 (en) | 1997-08-29 |
HK1008019A1 (en) | 1999-04-30 |
DE69030632T2 (de) | 1997-10-02 |
AU4850290A (en) | 1990-07-26 |
US4968702A (en) | 1990-11-06 |
DK0379145T3 (da) | 1997-05-26 |
KR0140076B1 (ko) | 1998-06-01 |
AU624471B2 (en) | 1992-06-11 |
ATE152711T1 (de) | 1997-05-15 |
EP0379145A3 (fr) | 1991-07-17 |
EP0379145B1 (fr) | 1997-05-07 |
CA2007740C (fr) | 1999-12-07 |
JPH02229166A (ja) | 1990-09-11 |
ES2100851T3 (es) | 1997-07-01 |
IE900169L (en) | 1990-07-17 |
IL92898A (en) | 1994-11-28 |
NZ232111A (en) | 1992-07-28 |
ZA90299B (en) | 1990-10-31 |
EP0379145A2 (fr) | 1990-07-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKEC | Expiry (correction) |
Effective date: 20121202 |