CA2005502C - Analogues de la somatotrophine - Google Patents

Analogues de la somatotrophine

Info

Publication number
CA2005502C
CA2005502C CA 2005502 CA2005502A CA2005502C CA 2005502 C CA2005502 C CA 2005502C CA 2005502 CA2005502 CA 2005502 CA 2005502 A CA2005502 A CA 2005502A CA 2005502 C CA2005502 C CA 2005502C
Authority
CA
Canada
Prior art keywords
bst
somatotropin
serine
mammalian
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 2005502
Other languages
English (en)
Other versions
CA2005502A1 (fr
Inventor
Alan J. Parcells
John E. Mott
Che-Shen C. Tomich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of CA2005502A1 publication Critical patent/CA2005502A1/fr
Application granted granted Critical
Publication of CA2005502C publication Critical patent/CA2005502C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA 2005502 1989-01-31 1989-12-15 Analogues de la somatotrophine Expired - Fee Related CA2005502C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30473389A 1989-01-31 1989-01-31
US07/304,733 1989-01-31

Publications (2)

Publication Number Publication Date
CA2005502A1 CA2005502A1 (fr) 1990-07-31
CA2005502C true CA2005502C (fr) 2001-06-05

Family

ID=23177749

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2005502 Expired - Fee Related CA2005502C (fr) 1989-01-31 1989-12-15 Analogues de la somatotrophine

Country Status (6)

Country Link
EP (1) EP0456642A1 (fr)
JP (1) JP3207416B2 (fr)
AU (1) AU620673B2 (fr)
CA (1) CA2005502C (fr)
DK (1) DK140491A (fr)
WO (1) WO1990008823A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0355460B1 (fr) * 1988-08-24 2000-12-27 American Cyanamid Company Stabilisation de somatotropines par modification du résidu cystéine en utilisant un site de mutagénèse dirigée ou par modification chimique
US5688666A (en) * 1988-10-28 1997-11-18 Genentech, Inc. Growth hormone variants with altered binding properties
US5534617A (en) * 1988-10-28 1996-07-09 Genentech, Inc. Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
US5849694A (en) * 1990-07-16 1998-12-15 Synenki; Richard M. Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
PT1568772E (pt) * 1995-09-21 2010-04-14 Genentech Inc Variantes da hormona do crescimento humana
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
CA2519092C (fr) 2003-03-14 2014-08-05 Neose Technologies, Inc. Polymeres hydrosolubles ramifies et conjugues de ceux-ci
PL1615945T3 (pl) 2003-04-09 2012-03-30 Ratiopharm Gmbh Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
BRPI0410164A (pt) * 2003-05-09 2006-05-16 Neose Technologies Inc composições e métodos para preparação de mutantes de glicosilação de hormÈnio do crescimento humano
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
KR101439880B1 (ko) 2004-01-08 2014-09-12 라티오팜 게엠베하 펩티드의 오-결합형 글리코실화
EP1771066A2 (fr) 2004-07-13 2007-04-11 Neose Technologies, Inc. Remodelage de peg ramifie et glycosylation de peptide-1 semblable a glucagon glp-1
EP1799249A2 (fr) 2004-09-10 2007-06-27 Neose Technologies, Inc. Interferon alpha glycopegyle
WO2006050247A2 (fr) 2004-10-29 2006-05-11 Neose Technologies, Inc. Remodelage et glycopegylation du facteur de croissance des fibroblastes (fgf)
NZ556436A (en) 2005-01-10 2010-11-26 Biogenerix Ag Glycopegylated granulocyte colony stimulating factor
EP2386571B1 (fr) 2005-04-08 2016-06-01 ratiopharm GmbH Compositions et méthodes utilisées pour la préparation de mutants par glycosylation de l'hormone de croissance humaine résistant à la protéase
WO2006127910A2 (fr) 2005-05-25 2006-11-30 Neose Technologies, Inc. Formulations d'erythropoietine glycopegylees
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
ES2516694T3 (es) 2006-07-21 2014-10-31 Ratiopharm Gmbh Glicosilación de péptidos a través de secuencias de glicosilación con unión en O
WO2008057683A2 (fr) 2006-10-03 2008-05-15 Novo Nordisk A/S Méthodes de purification de conjugués de polypeptides
BRPI0809670A8 (pt) 2007-04-03 2018-12-18 Biogenerix Ag métodos para aumentar a produção de célula tronco, para aumentar o número de granulócitos em um indivíduo, para prevenir, tratar e aliviar a mielossupressão que resulta de uma terapia contra o câncer, para tratar uma condição em um indivíduo, para tratar neutropenia e trombocitopenia em um mamífero, para expandir células tronco hematopoiéticas em cultura, para aumentar a hematopoiese em um indivíduo, para aumentar o número de célulars progenitoras hematopoiéticas em um indivíduo, e para fornecer enxerto estável da medula óssea, e, forma de dosagem oral.
CN101778859B (zh) 2007-06-12 2014-03-26 诺和诺德公司 改良的用于生产核苷酸糖的方法
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
CN103497246B (zh) 2008-02-27 2016-08-10 诺沃—诺迪斯克有限公司 缀合的因子viii分子

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.

Also Published As

Publication number Publication date
JPH04503001A (ja) 1992-06-04
JP3207416B2 (ja) 2001-09-10
AU620673B2 (en) 1992-02-20
DK140491D0 (da) 1991-07-29
EP0456642A1 (fr) 1991-11-21
DK140491A (da) 1991-07-29
WO1990008823A1 (fr) 1990-08-09
AU4663189A (en) 1990-08-24
CA2005502A1 (fr) 1990-07-31

Similar Documents

Publication Publication Date Title
CA2005502C (fr) Analogues de la somatotrophine
CA1338981C (fr) Proteines biologiquement actives et methode de preparation
AU634517B2 (en) Somatotropin analogs
US4831120A (en) Method for recovering a purified animal growth hormone or polypeptide analog thereof from a bacterial cell
JPS63500036A (ja) 線維芽細胞発育因子
JPH06133793A (ja) ミュレル管抑制物質様ポリペプチドおよびその製造方法
US4861868A (en) Production of proteins in procaryotes
US5605815A (en) Nucleic acids encoding and expression of parathyroid hormone-like peptide
US5141922A (en) Biologically active proteins and a method for their use
EP0645454A2 (fr) Proteine contenant une somatostatine chimère, DNA codant, compositions immunogènes, et procédé d'amélioration de la productivité d'animaux de farmes
RU2034457C1 (ru) Способ повышения продуктивности сельскохозяйственных животных и препарат для его осуществления
US5631227A (en) Somatotropin analogs
AU633278B2 (en) Isolation and cloning of complementary dna for gene coding of bovine trophoblast protein-1
EP0236452B1 (fr) Bioactivite amelioree de la somatotropine mammifere par desamidation selective
EP0263206B1 (fr) Bioactivité élevée de la somatotropine des mammifères par désamidation sélective
EP0473080B1 (fr) Protéine chondromodulin-I
CN1160721A (zh) 成纤维细胞生长因子-2结构类似物，其生产方法及应用
EP0363063A2 (fr) Hormone de croissance ovine
HUT50501A (en) Process for producing new polypeptides of growth factor activity and nucleinic-acid-sequences coding them
AU647374B2 (en) Sheep growth hormone
US5759816A (en) Expression vectors containing λPL promoter and T1 T2 rRNA termination sequence plasmids containing the vectors hosts containing the plasmids and related methods
CN1500810A (zh) 成纤维细胞生长因子-2结构类似物,其生产方法及应用

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed