CA1337656C - Substrates for phospholipases - Google Patents
Substrates for phospholipasesInfo
- Publication number
- CA1337656C CA1337656C CA000590628A CA590628A CA1337656C CA 1337656 C CA1337656 C CA 1337656C CA 000590628 A CA000590628 A CA 000590628A CA 590628 A CA590628 A CA 590628A CA 1337656 C CA1337656 C CA 1337656C
- Authority
- CA
- Canada
- Prior art keywords
- radical
- carbon atoms
- reagent
- acid
- phospholipase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
- C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
- C07C305/10—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3807123A DE3807123A1 (de) | 1988-03-04 | 1988-03-04 | Substrate fuer phospholipasen |
| DEP3807123.1 | 1988-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1337656C true CA1337656C (en) | 1995-11-28 |
Family
ID=6348884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000590628A Expired - Fee Related CA1337656C (en) | 1988-03-04 | 1989-02-09 | Substrates for phospholipases |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5091527A (show.php) |
| EP (1) | EP0331167B1 (show.php) |
| JP (1) | JPH023662A (show.php) |
| AT (1) | ATE78484T1 (show.php) |
| AU (1) | AU600869B2 (show.php) |
| CA (1) | CA1337656C (show.php) |
| DE (2) | DE3807123A1 (show.php) |
| ES (1) | ES2034437T3 (show.php) |
| GR (1) | GR3005766T3 (show.php) |
| ZA (1) | ZA891607B (show.php) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8076520B2 (en) | 1996-02-16 | 2011-12-13 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Phosphatidyl oligoglycerols |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU643952B2 (en) * | 1989-08-29 | 1993-12-02 | Regents Of The University Of California, The | Novel hydrolytic enzyme inhibitors and substrates and assays, methods and kits embodying same |
| US5308766A (en) * | 1989-08-29 | 1994-05-03 | The Regents Of The University Of California | Hydrolytic enzyme inhibitors/inactivators and methods for using same |
| US5352673A (en) * | 1989-08-29 | 1994-10-04 | Dennis Edward A | Prodrugs |
| DE4029845A1 (de) * | 1990-09-20 | 1992-03-26 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von phospholipase in koerperfluessigkeiten |
| JP4220603B2 (ja) * | 1998-12-02 | 2009-02-04 | アルフレッサファーマ株式会社 | 血小板活性化因子アセチルヒドロラーゼ活性の測定方法 |
| WO2002002570A1 (en) * | 2000-07-25 | 2002-01-10 | Eli Lilly And Company | Chromogenic compound |
| AU2003222427B8 (en) * | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| EP2277887A3 (en) | 2001-10-19 | 2011-02-16 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
| US7741020B2 (en) | 2004-04-16 | 2010-06-22 | Glaxo Group Limited | Methods for detecting Lp-PLA2 activity and inhibition of Lp-PLA2 activity |
| US20150017671A1 (en) | 2004-04-16 | 2015-01-15 | Yaping Shou | Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity |
| US7807847B2 (en) | 2004-07-09 | 2010-10-05 | Vascular Biogenics Ltd. | Process for the preparation of oxidized phospholipids |
| US9006217B2 (en) | 2007-01-09 | 2015-04-14 | Vascular Biogenics Ltd. | High-purity phospholipids |
| US8569529B2 (en) | 2007-01-09 | 2013-10-29 | Vascular Biogenics Ltd. | High-purity phospholipids |
| WO2010052718A1 (en) * | 2008-11-06 | 2010-05-14 | Vascular Biogenics Ltd. | Oxidized lipid compounds and uses thereof |
| US20140283157A1 (en) | 2013-03-15 | 2014-09-18 | Diadexus, Inc. | Lipoprotein-associated phospholipase a2 antibody compositions and methods of use |
| US9771385B2 (en) | 2014-11-26 | 2017-09-26 | Vascular Biogenics Ltd. | Oxidized lipids |
| CA2968790A1 (en) | 2014-11-26 | 2016-06-02 | Vascular Biogenics Ltd. | Oxidized lipids and treatment or prevention of fibrosis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4493832A (en) * | 1981-07-03 | 1985-01-15 | Fujisawa Pharmaceutical Co., Ltd. | Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same |
| US4485045A (en) * | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| FR2517310A1 (fr) * | 1981-11-27 | 1983-06-03 | Unilever Nv | Derives d'a-glycerophosphatidester, procede pour leur preparation, composition cosmetique ou pharmaceutique les contenant |
| JPS5931786A (ja) * | 1982-08-16 | 1984-02-20 | Hidetoshi Tsuchida | ホスフアチジルコリン型リン脂質化合物 |
| DE3516001A1 (de) * | 1985-05-03 | 1986-11-06 | Boehringer Mannheim Gmbh, 6800 Mannheim | Lipasefarbtest |
| EP0225129B1 (en) * | 1985-11-29 | 1989-05-24 | Takeda Chemical Industries, Ltd. | Phospholipid derivatives, their production and use |
| AU607698B2 (en) * | 1986-03-24 | 1991-03-14 | Macquarie University | Antigenic analogues of platelet activating factor (paf) |
| IL84387A0 (en) * | 1987-11-06 | 1990-02-09 | Rapaport Erich | Pharmaceutical compositions containing a substituted phosphatide |
-
1988
- 1988-03-04 DE DE3807123A patent/DE3807123A1/de not_active Withdrawn
-
1989
- 1989-02-09 CA CA000590628A patent/CA1337656C/en not_active Expired - Fee Related
- 1989-03-01 JP JP1046717A patent/JPH023662A/ja active Granted
- 1989-03-02 ES ES198989103660T patent/ES2034437T3/es not_active Expired - Lifetime
- 1989-03-02 EP EP89103660A patent/EP0331167B1/de not_active Expired - Lifetime
- 1989-03-02 US US07/318,075 patent/US5091527A/en not_active Expired - Fee Related
- 1989-03-02 DE DE8989103660T patent/DE58901860D1/de not_active Expired - Lifetime
- 1989-03-02 AU AU30943/89A patent/AU600869B2/en not_active Ceased
- 1989-03-02 ZA ZA891607A patent/ZA891607B/xx unknown
- 1989-03-02 AT AT89103660T patent/ATE78484T1/de active
-
1992
- 1992-09-24 GR GR920401478T patent/GR3005766T3/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8076520B2 (en) | 1996-02-16 | 2011-12-13 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Phosphatidyl oligoglycerols |
Also Published As
| Publication number | Publication date |
|---|---|
| DE58901860D1 (en) | 1992-08-27 |
| EP0331167A2 (de) | 1989-09-06 |
| US5091527A (en) | 1992-02-25 |
| ES2034437T3 (es) | 1993-04-01 |
| JPH023662A (ja) | 1990-01-09 |
| AU600869B2 (en) | 1990-08-23 |
| EP0331167B1 (de) | 1992-07-22 |
| ZA891607B (en) | 1989-11-29 |
| DE3807123A1 (de) | 1989-09-14 |
| JPH0466864B2 (show.php) | 1992-10-26 |
| GR3005766T3 (show.php) | 1993-06-07 |
| AU3094389A (en) | 1989-09-07 |
| EP0331167A3 (en) | 1989-11-15 |
| ATE78484T1 (de) | 1992-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |