CA1322749C - Prostaglandins of the d series, and tranquilizers and soporifics containing the same - Google Patents
Prostaglandins of the d series, and tranquilizers and soporifics containing the sameInfo
- Publication number
- CA1322749C CA1322749C CA000557480A CA557480A CA1322749C CA 1322749 C CA1322749 C CA 1322749C CA 000557480 A CA000557480 A CA 000557480A CA 557480 A CA557480 A CA 557480A CA 1322749 C CA1322749 C CA 1322749C
- Authority
- CA
- Canada
- Prior art keywords
- dihydro
- keto
- pgd2
- methyl
- methyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003180 prostaglandins Chemical class 0.000 title claims abstract description 18
- 229940094443 oxytocics prostaglandins Drugs 0.000 title claims abstract description 13
- 230000002557 soporific effect Effects 0.000 title claims description 6
- 239000003204 tranquilizing agent Substances 0.000 title claims description 6
- 230000002936 tranquilizing effect Effects 0.000 title claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 24
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims abstract description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 18
- 239000001257 hydrogen Substances 0.000 claims abstract description 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 14
- 125000006239 protecting group Chemical group 0.000 claims abstract description 7
- 150000003839 salts Chemical class 0.000 claims abstract description 7
- 125000001033 ether group Chemical group 0.000 claims abstract description 6
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract description 6
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 5
- 150000002367 halogens Chemical class 0.000 claims abstract description 5
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 5
- 239000000203 mixture Substances 0.000 claims description 19
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 229940125725 tranquilizer Drugs 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 240000002989 Euphorbia neriifolia Species 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 description 65
- 230000015572 biosynthetic process Effects 0.000 description 57
- 238000003786 synthesis reaction Methods 0.000 description 57
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 39
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 36
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 27
- 238000012360 testing method Methods 0.000 description 24
- 239000000243 solution Substances 0.000 description 22
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 21
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 20
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 18
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
- VSRXYLYXIXYEST-KZTWKYQFSA-N 13,14-dihydro-15-ketoprostaglandin D2 Chemical compound CCCCCC(=O)CC[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O VSRXYLYXIXYEST-KZTWKYQFSA-N 0.000 description 17
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 description 16
- 101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 description 16
- -1 for example Substances 0.000 description 16
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 description 16
- 150000002009 diols Chemical class 0.000 description 15
- 125000005907 alkyl ester group Chemical group 0.000 description 14
- 125000000217 alkyl group Chemical group 0.000 description 14
- 239000012043 crude product Substances 0.000 description 13
- 125000004494 ethyl ester group Chemical group 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 12
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 12
- 230000001624 sedative effect Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 150000002148 esters Chemical group 0.000 description 11
- 239000002504 physiological saline solution Substances 0.000 description 11
- CZEBTZMIQZVUSE-UHFFFAOYSA-N [6-cyano-1-[(2-methylpropan-2-yl)oxycarbonyl]indol-2-yl]boronic acid Chemical compound C1=C(C#N)C=C2N(C(=O)OC(C)(C)C)C(B(O)O)=CC2=C1 CZEBTZMIQZVUSE-UHFFFAOYSA-N 0.000 description 10
- 235000019441 ethanol Nutrition 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- HUHXLHLWASNVDB-UHFFFAOYSA-N 2-(oxan-2-yloxy)oxane Chemical compound O1CCCCC1OC1OCCCC1 HUHXLHLWASNVDB-UHFFFAOYSA-N 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- 101000631899 Homo sapiens Ribosome maturation protein SBDS Proteins 0.000 description 8
- 102100028750 Ribosome maturation protein SBDS Human genes 0.000 description 8
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 238000001990 intravenous administration Methods 0.000 description 8
- 150000002596 lactones Chemical class 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000012046 mixed solvent Substances 0.000 description 8
- 230000001939 inductive effect Effects 0.000 description 7
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 7
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
- 239000003810 Jones reagent Substances 0.000 description 5
- 150000002576 ketones Chemical class 0.000 description 5
- 229920006395 saturated elastomer Polymers 0.000 description 5
- 229920000858 Cyclodextrin Polymers 0.000 description 4
- BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 description 4
- 101150020741 Hpgds gene Proteins 0.000 description 4
- WNBMQMMGBBWUOZ-BYNKDMOPSA-N Prostaglandin D2 methyl ester Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(=O)OC)[C@@H](O)CC1=O WNBMQMMGBBWUOZ-BYNKDMOPSA-N 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 229960002986 dinoprostone Drugs 0.000 description 4
- 230000002093 peripheral effect Effects 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 150000003346 selenoethers Chemical class 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 4
- 238000010626 work up procedure Methods 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 3
- 206010062519 Poor quality sleep Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 210000001772 blood platelet Anatomy 0.000 description 3
- 230000002490 cerebral effect Effects 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
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- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000010253 intravenous injection Methods 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 3
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 3
- 230000001766 physiological effect Effects 0.000 description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 description 3
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- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 3
- 238000010254 subcutaneous injection Methods 0.000 description 3
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- 239000000725 suspension Substances 0.000 description 3
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 3
- 210000000211 third ventricle Anatomy 0.000 description 3
- 230000024883 vasodilation Effects 0.000 description 3
- DAPZSGCXUJECAI-UHFFFAOYSA-N 4-[tert-butyl(dimethyl)silyl]oxycyclopent-2-en-1-one Chemical compound CC(C)(C)[Si](C)(C)OC1CC(=O)C=C1 DAPZSGCXUJECAI-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 101100268474 Arabidopsis thaliana PGD3 gene Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010006482 Bronchospasm Diseases 0.000 description 2
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 2
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- 108010010803 Gelatin Proteins 0.000 description 2
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- CIMMACURCPXICP-PNQRDDRVSA-N prostaglandin D1 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](CCCCCCC(O)=O)[C@@H](O)CC1=O CIMMACURCPXICP-PNQRDDRVSA-N 0.000 description 1
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- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18821/1987 | 1987-01-28 | ||
| JP1882187 | 1987-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1322749C true CA1322749C (en) | 1993-10-05 |
Family
ID=11982228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000557480A Expired - Lifetime CA1322749C (en) | 1987-01-28 | 1988-01-27 | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
Country Status (8)
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212200A (en) * | 1987-09-18 | 1993-05-18 | R-Tech Ueno, Ltd. | Ocular hypotensive agents |
| US6420422B1 (en) | 1987-09-18 | 2002-07-16 | Sucampo Pharmaceuticals, Inc. | Ocular hypotensive agents |
| ATE82499T1 (de) * | 1987-09-18 | 1992-12-15 | R Tech Ueno Ltd | Okulare hypotensivagenzien. |
| JP2597629B2 (ja) | 1988-02-26 | 1997-04-09 | 株式会社 上野製薬応用研究所 | １３，１４−ジヒドロ−１５−ケトプロスタグランジン類の安定化 |
| US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US6187813B1 (en) | 1990-04-10 | 2001-02-13 | Pharmacia & Upjohn Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| EP1224934A3 (en) | 1988-09-06 | 2003-03-26 | Pharmacia AB | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5234954A (en) * | 1989-07-27 | 1993-08-10 | K.K. Ueno Seiyaku Oyo Kenkyujo | Treatment of hyperlipidemia with 15-keto-prostaglandin compounds |
| ATE122563T1 (de) * | 1989-07-27 | 1995-06-15 | Ueno Seiyaku Oyo Kenkyujo Kk | Verwendung von 15-keto-prostansäure-derivaten zur herstellung eines medikaments für die verbesserung der ausscheidung des kaliumions. |
| EP0415564B1 (en) * | 1989-08-09 | 1995-04-26 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Use of prostanoic acid derivaties for the manufacture of a medicament for improvement of excretion of nonprotein nitrogen into the intestine |
| CA2027814C (en) * | 1989-10-20 | 1996-07-30 | Ryuji Ueno | Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds |
| US5256696A (en) * | 1989-11-22 | 1993-10-26 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds |
| CA2030345C (en) * | 1989-11-22 | 1998-12-08 | Ryuji Ueno | Use of 15-keto-prostaglandin compound for improvement of encephalic function |
| US5254588A (en) * | 1989-11-22 | 1993-10-19 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds |
| TW249226B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1990-04-04 | 1995-06-11 | Aderk Ueno Kk | |
| CA2046069C (en) * | 1990-07-10 | 2002-04-09 | Ryuji Ueno | Treatment of inflammatory diseases with 15-keto-prostaglandin compounds |
| DE69213057T2 (de) * | 1991-03-14 | 1997-01-09 | Ueno Seiyaku Oyo Kenkyujo Kk | Stimulierung von Wundheilung mit 15-Keto-prostaglandinverbindungen |
| PT1083168E (pt) | 1998-05-25 | 2004-03-31 | Taisho Pharmaceutical Co Ltd | Derivado de prostaglandina |
| AR030275A1 (es) | 2000-03-24 | 2003-08-20 | Sucampo Pharmaceuticals Inc | Composicion que inhibe la apoptosis y uso de un compuesto 15-ceto-prostaglandina- para producirla |
| MXPA02009915A (es) * | 2000-04-06 | 2003-03-27 | Sucampo Ag | Composicion promotora de secrecion de bilis. |
| TWI302100B (en) | 2001-05-02 | 2008-10-21 | Sucampo Ag | Composition for treating drug-induced constipation |
| EP1420794B1 (en) | 2001-08-31 | 2017-12-27 | Sucampo AG | Prostaglandin analogs as chloride channel openers |
| WO2005018646A1 (ja) | 2003-08-21 | 2005-03-03 | Sucampo Ag | 眼科用組成物 |
| AU2003274735B2 (en) * | 2002-10-23 | 2008-12-04 | Sucampo Ag | Prostaglandin compounds for the treatment of obesity |
| KR101164838B1 (ko) | 2002-12-27 | 2012-07-11 | 수캄포 아게 | 복부 불쾌감 치료용 프로스타글랜딘의 유도체 |
| ATE489096T1 (de) * | 2003-07-03 | 2010-12-15 | Sucampo Ag | Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner |
| TWI495471B (zh) * | 2003-08-12 | 2015-08-11 | R Tech Ueno Ltd | 促進毛髮生長之組成物及方法 |
| US7321057B2 (en) * | 2004-08-02 | 2008-01-22 | R-Tech Ueno, Ltd. | Method for manufacturing prostaglandin analogue |
| CN101146541B (zh) | 2005-01-27 | 2012-04-11 | 苏坎波公司 | 用于治疗中枢神经系统疾病的方法和组合物 |
| AR055038A1 (es) | 2005-03-04 | 2007-08-01 | Sucampo Ag | Metodo y compuesto para tratar enfermedades vasculares perifericas |
| US20060281818A1 (en) | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| AU2006234632B2 (en) * | 2005-04-12 | 2011-10-27 | Sucampo Ag | Combined use of prostaglandin compound and proton pump inhibitor for the treatment of gastrointestinal disorders |
| CN104971056A (zh) | 2006-01-24 | 2015-10-14 | 株式会社·R-技术上野 | 软明胶胶囊制剂 |
| MX2008009652A (es) | 2006-01-24 | 2008-11-06 | R Tech Ueno Ltd | Composicion farmaceutica que comprende un compuesto biciclico y metodo para estabilizar el compuesto biciclico. |
| US20090062381A1 (en) | 2006-03-13 | 2009-03-05 | Ryu Hirata | Aqueous composition |
| US8871752B2 (en) * | 2008-02-19 | 2014-10-28 | Sucampo Ag | Method for modulating stem cell growth |
| US8609729B2 (en) | 2009-04-15 | 2013-12-17 | Sucampo Ag | Method for treating macular degeneration |
| US8569279B2 (en) * | 2009-05-27 | 2013-10-29 | Sucampo Ag | Method for modulating claudin mediated functions |
| US9084815B2 (en) * | 2009-09-16 | 2015-07-21 | Sucampo Ag | Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor |
| CA2830626A1 (en) | 2011-04-07 | 2012-10-11 | Sucampo Ag | Method for treating asthenopia |
| BR112014002712A8 (pt) | 2011-08-05 | 2017-06-20 | Sucampo Ag | método para tratamento da esquizofrenia |
| AR092821A1 (es) | 2012-04-20 | 2015-05-06 | Sucampo Ag | Conjugado de derivado de acido graso-polimero |
| US20150057351A1 (en) | 2013-08-22 | 2015-02-26 | Sucampo Ag | Method for treating neuropathic pain |
| US20170020890A1 (en) | 2015-06-19 | 2017-01-26 | Sucampo Ag | Pharmaceutical composition comprising fatty acid derivative |
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|---|---|---|---|---|
| GB1476661A (en) * | 1974-05-13 | 1977-06-16 | American Cyanamid Co | Prostaglandins |
| ATE82499T1 (de) * | 1987-09-18 | 1992-12-15 | R Tech Ueno Ltd | Okulare hypotensivagenzien. |
-
1988
- 1988-01-27 CA CA000557480A patent/CA1322749C/en not_active Expired - Lifetime
- 1988-01-28 EP EP88300710A patent/EP0281239B1/en not_active Expired - Lifetime
- 1988-01-28 ES ES198888300710T patent/ES2032956T3/es not_active Expired - Lifetime
- 1988-01-28 DE DE8888300710T patent/DE3869444D1/de not_active Expired - Lifetime
- 1988-01-28 KR KR1019880000703A patent/KR930006201B1/ko not_active Expired - Fee Related
- 1988-01-28 AT AT88300710T patent/ATE74126T1/de not_active IP Right Cessation
-
1989
- 1989-09-06 US US07/403,774 patent/US5073569A/en not_active Expired - Lifetime
-
1991
- 1991-06-13 US US07/715,151 patent/US5137915A/en not_active Expired - Lifetime
-
1992
- 1992-04-07 GR GR910402220T patent/GR3004281T3/el unknown
-
1994
- 1994-09-23 US US08/310,109 patent/US5534547A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5137915A (en) | 1992-08-11 |
| GR3004281T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-03-31 |
| ES2032956T3 (es) | 1993-03-01 |
| KR930006201B1 (ko) | 1993-07-08 |
| DE3869444D1 (de) | 1992-04-30 |
| ATE74126T1 (de) | 1992-04-15 |
| US5073569A (en) | 1991-12-17 |
| EP0281239A2 (en) | 1988-09-07 |
| EP0281239A3 (en) | 1988-09-21 |
| US5534547A (en) | 1996-07-09 |
| EP0281239B1 (en) | 1992-03-25 |
| KR880008986A (ko) | 1988-09-13 |
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Legal Events
| Date | Code | Title | Description |
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| MKEX | Expiry |
Effective date: 20101005 |