CA1285934C - Derives poly-4-aminopyrrole-2-carboxamido et procede de preparation - Google Patents

Derives poly-4-aminopyrrole-2-carboxamido et procede de preparation

Info

Publication number
CA1285934C
CA1285934C CA000513760A CA513760A CA1285934C CA 1285934 C CA1285934 C CA 1285934C CA 000513760 A CA000513760 A CA 000513760A CA 513760 A CA513760 A CA 513760A CA 1285934 C CA1285934 C CA 1285934C
Authority
CA
Canada
Prior art keywords
methyl
carboxamido
pyrrole
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000513760A
Other languages
English (en)
Inventor
Sergio Penco
Nicola Mongelli
Federico Arcamone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858517922A external-priority patent/GB8517922D0/en
Priority claimed from GB868613594A external-priority patent/GB8613594D0/en
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of CA1285934C publication Critical patent/CA1285934C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyamides (AREA)
CA000513760A 1985-07-16 1986-07-15 Derives poly-4-aminopyrrole-2-carboxamido et procede de preparation Expired - Fee Related CA1285934C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8517922 1985-07-16
GB858517922A GB8517922D0 (en) 1985-07-16 1985-07-16 Carboxamido derivatives
GB8613594 1986-06-04
GB868613594A GB8613594D0 (en) 1986-06-04 1986-06-04 Poly-4-aminopyrrole-2-carboxamido derivatives

Publications (1)

Publication Number Publication Date
CA1285934C true CA1285934C (fr) 1991-07-09

Family

ID=26289538

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000513760A Expired - Fee Related CA1285934C (fr) 1985-07-16 1986-07-15 Derives poly-4-aminopyrrole-2-carboxamido et procede de preparation

Country Status (26)

Country Link
JP (1) JPH0780843B2 (fr)
KR (1) KR930010496B1 (fr)
CN (1) CN1018825B (fr)
AT (1) AT387013B (fr)
AU (1) AU587841B2 (fr)
BE (1) BE905110A (fr)
CA (1) CA1285934C (fr)
CH (1) CH674206A5 (fr)
CS (1) CS276981B6 (fr)
DE (1) DE3623880A1 (fr)
DK (1) DK335986A (fr)
ES (1) ES2000502A6 (fr)
FI (1) FI83640C (fr)
FR (1) FR2585018B1 (fr)
GB (1) GB2178036B (fr)
GR (1) GR861841B (fr)
HU (1) HU205949B (fr)
IE (1) IE59073B1 (fr)
IL (1) IL79402A (fr)
IT (1) IT1196488B (fr)
NL (1) NL8601837A (fr)
NO (1) NO168826C (fr)
NZ (1) NZ216829A (fr)
PH (1) PH24714A (fr)
PT (1) PT82984B (fr)
SE (1) SE468642B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
IT1243389B (it) * 1990-11-22 1994-06-10 Menarini Farma Ind Derivati poliaminopirrolcarbossiamidici, processi di preparazione e composizioni farmaceutiche che li contengono.
WO1992013838A1 (fr) * 1991-02-06 1992-08-20 Synphar Laboratories, Inc. Agents antiretroviraux oligopeptidiques
IT1247878B (it) * 1991-02-15 1995-01-05 Menarini Farma Ind Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono
GB2260134A (en) * 1991-10-04 1993-04-07 Erba Carlo Spa Derivatives of poly-5-amino-3-carboxy-1-methyl compounds
IT1262921B (it) * 1992-01-10 1996-07-22 Federico Arcamone Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
CA2204648A1 (fr) * 1995-09-12 1997-03-20 Akira Mihara Composes de souche uch 15
JP2000503999A (ja) * 1996-02-02 2000-04-04 フアルマシア・エ・アツプジヨン・エツセ・ピー・アー ジスタマイシン誘導体、その調製方法、および抗腫瘍および抗ウイルス剤としてのその使用
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR86210E (fr) 1963-04-04 1966-03-23
BE666612A (fr) * 1963-07-26 1965-11-03
BR6461040D0 (pt) * 1963-07-26 1973-08-02 Farmaceutici Italia Processo para preparar novos derivados de pirrol
DE1795539A1 (de) * 1963-07-26 1972-01-13 Farmaceutici Italia Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
NL130086C (fr) * 1964-07-14 1970-06-15
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法

Also Published As

Publication number Publication date
IT8621125A1 (it) 1988-01-15
AU587841B2 (en) 1989-08-31
CH674206A5 (fr) 1990-05-15
PT82984B (pt) 1989-01-30
ES2000502A6 (es) 1988-03-01
CN86104787A (zh) 1987-02-18
NO862860L (no) 1987-01-19
FR2585018B1 (fr) 1989-07-13
AU6020286A (en) 1987-01-22
IL79402A0 (en) 1986-10-31
CN1018825B (zh) 1992-10-28
JPH0780843B2 (ja) 1995-08-30
CS276981B6 (en) 1992-11-18
JPS6277362A (ja) 1987-04-09
PT82984A (en) 1986-08-01
IL79402A (en) 1991-06-10
FI862959A0 (fi) 1986-07-16
GB2178036A (en) 1987-02-04
FI83640B (fi) 1991-04-30
KR870001201A (ko) 1987-03-12
PH24714A (en) 1990-10-01
FI862959A (fi) 1987-01-17
GR861841B (en) 1986-11-18
NO862860D0 (no) 1986-07-15
NL8601837A (nl) 1987-02-16
GB8617292D0 (en) 1986-08-20
HU205949B (en) 1992-07-28
DK335986A (da) 1987-01-17
SE8603098L (sv) 1987-01-17
FI83640C (fi) 1991-08-12
ATA188886A (de) 1988-04-15
IE59073B1 (en) 1994-01-12
KR930010496B1 (ko) 1993-10-25
FR2585018A1 (fr) 1987-01-23
SE8603098D0 (sv) 1986-07-11
HUT43088A (en) 1987-09-28
IT1196488B (it) 1988-11-16
NO168826C (no) 1992-04-08
AT387013B (de) 1988-11-25
DE3623880A1 (de) 1987-01-29
BE905110A (fr) 1987-01-15
DK335986D0 (da) 1986-07-15
IE861875L (en) 1987-01-16
IT8621125A0 (it) 1986-07-15
GB2178036B (en) 1989-08-16
SE468642B (sv) 1993-02-22
NZ216829A (en) 1989-03-29
CS8605412A2 (en) 1991-03-12
NO168826B (no) 1991-12-30

Similar Documents

Publication Publication Date Title
CA1285934C (fr) Derives poly-4-aminopyrrole-2-carboxamido et procede de preparation
US5017599A (en) Site specific alkylating agents
DE69726593T2 (de) Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel
US4766142A (en) Poly-4-aminopyrrole-2-carboxamido derivatives and their use as antiuiral or antitumor agents
US6080750A (en) Pyrimidine compound and anti-rotavirus composition
EP0354495A1 (fr) Dérivés de alkoxy-4(1H)pyridone, procédé pour leur préparation et leur utilisation comme médicament
DE4219158A1 (de) Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
GB2178037A (en) Distamycin derivatives and process for their preparation
EP1529041B1 (fr) Nouveaux promedicaments de 1-methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-acide carboxylique-(n-2-pyridil-n-2-hydroxycarbonylethyl)-amide, leur preparation et leur utilisation en tant que medicaments
DD283402A5 (de) Verfahren zur herstellung von 2-substituierten adenosinderivaten
CA1120471A (fr) Obtention de 2-adamantylhydrazines et de substances pharmaceutiques qui en contiennent
DE3309596A1 (de) 2-substituierte 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-ss-carboline, ihre herstellung und verwendung als arzneimittel
US4379160A (en) Carbazole compounds and medicinal use thereof
US4714764A (en) 2-(4-pyridylaminomethyl)-benzimidazole derivatives having antiviral activity
US4400383A (en) Treatment of anxiety
DE2424670A1 (de) Triazolo-isoindol-derivate und verfahren zu deren herstellung
WO2008142623A2 (fr) Inhibiteurs du facteur de nécrose tumorale alpha
DE60311284T2 (de) 4-(3,5-dicyanophenoxy)pyrazol-derivate zur verwendung als reverse transkriptase modulatoren zur behandlung von u.a. hiv
EP0585116B1 (fr) Dérivés de 1-alkoxy-naphtalène-2-carboxamide avec grande affinité pour le récepteur de sérotonine 5-HT1A
TAKAI et al. Synthesis of 1-and 3-(1-Substituted 4-Piperidinyl)-1, 2, 3, 4-tetrahydro-2-oxoquinazolines as Potential Antihypertensive Agents
EP0663395B1 (fr) Dérivés de 3-(phénylalkylaminoalkyloxy)-5-phénylpyrazole, procédé et intermédiaires pour leur préparation et leur utilisation comme agent de réduction du rythme cardiaque
US3373163A (en) N-methyl-piperazides of alicyclic and heterocyclic carboxylic acids
WO1991011444A1 (fr) Compose de piperazine, sa production et son utilisation en medecine
HUT68070A (en) Process for preparing substituted pyrrolidine derivatives and pharmaceutical compositions containing them
EP0877026B1 (fr) 6-r-1,3,4-thiadiazine-2-amines substitues, leur utilisation en qualite d'agents anesthesiques, cardio-vasculaires et hypometaboliques, et composition pharmaceutique les contenant

Legal Events

Date Code Title Description
MKLA Lapsed