CA1266661A - Derives acylmercaptoalcanoyle et mercaptoalcanoyle d'aryl- et d'aralcoylsulfinyl- ou sulfonyl-l- prolines - Google Patents

Derives acylmercaptoalcanoyle et mercaptoalcanoyle d'aryl- et d'aralcoylsulfinyl- ou sulfonyl-l- prolines

Info

Publication number
CA1266661A
CA1266661A CA000452213A CA452213A CA1266661A CA 1266661 A CA1266661 A CA 1266661A CA 000452213 A CA000452213 A CA 000452213A CA 452213 A CA452213 A CA 452213A CA 1266661 A CA1266661 A CA 1266661A
Authority
CA
Canada
Prior art keywords
methyl
proline
compound
salt
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000452213A
Other languages
English (en)
Other versions
CA1266661C (fr
Inventor
John Krapcho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Priority to CA615516A priority Critical patent/CA1271966C/fr
Priority to CA000452213A priority patent/CA1266661A/fr
Application granted granted Critical
Publication of CA1266661C publication Critical patent/CA1266661C/fr
Publication of CA1266661A publication Critical patent/CA1266661A/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA000452213A 1983-04-25 1984-04-17 Derives acylmercaptoalcanoyle et mercaptoalcanoyle d'aryl- et d'aralcoylsulfinyl- ou sulfonyl-l- prolines Expired - Lifetime CA1266661A (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA615516A CA1271966C (fr) 1983-04-25 1984-04-17 Les aryl-et aralarylsulfonyl-l-prolines
CA000452213A CA1266661A (fr) 1983-04-25 1984-04-17 Derives acylmercaptoalcanoyle et mercaptoalcanoyle d'aryl- et d'aralcoylsulfinyl- ou sulfonyl-l- prolines

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48847783A 1983-04-25 1983-04-25
US488,477 1983-04-25
CA000452213A CA1266661A (fr) 1983-04-25 1984-04-17 Derives acylmercaptoalcanoyle et mercaptoalcanoyle d'aryl- et d'aralcoylsulfinyl- ou sulfonyl-l- prolines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA615516A Division CA1271966C (fr) 1983-04-25 1984-04-17 Les aryl-et aralarylsulfonyl-l-prolines

Publications (2)

Publication Number Publication Date
CA1266661C CA1266661C (fr) 1990-03-13
CA1266661A true CA1266661A (fr) 1990-03-13

Family

ID=34117156

Family Applications (2)

Application Number Title Priority Date Filing Date
CA615516A Expired CA1271966C (fr) 1983-04-25 1984-04-17 Les aryl-et aralarylsulfonyl-l-prolines
CA000452213A Expired - Lifetime CA1266661A (fr) 1983-04-25 1984-04-17 Derives acylmercaptoalcanoyle et mercaptoalcanoyle d'aryl- et d'aralcoylsulfinyl- ou sulfonyl-l- prolines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA615516A Expired CA1271966C (fr) 1983-04-25 1984-04-17 Les aryl-et aralarylsulfonyl-l-prolines

Country Status (1)

Country Link
CA (2) CA1271966C (fr)

Also Published As

Publication number Publication date
CA1266661C (fr) 1990-03-13
CA1271966A (fr) 1990-07-24
CA1271966C (fr) 1990-07-24

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Legal Events

Date Code Title Description
MKLA Lapsed
MKLA Lapsed

Effective date: 19980313