CA1258429A - Microencapsulation of living cells - Google Patents

Microencapsulation of living cells

Info

Publication number
CA1258429A
CA1258429A CA000498218A CA498218A CA1258429A CA 1258429 A CA1258429 A CA 1258429A CA 000498218 A CA000498218 A CA 000498218A CA 498218 A CA498218 A CA 498218A CA 1258429 A CA1258429 A CA 1258429A
Authority
CA
Canada
Prior art keywords
microcapsule
polymer
acrylic polymer
membrane
polycationic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000498218A
Other languages
English (en)
French (fr)
Inventor
Hrire Gharapetian
Anthony M. Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Original Assignee
Connaught Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Connaught Laboratories Ltd filed Critical Connaught Laboratories Ltd
Application granted granted Critical
Publication of CA1258429A publication Critical patent/CA1258429A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA000498218A 1985-01-03 1985-12-20 Microencapsulation of living cells Expired CA1258429A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8500121 1985-01-03
GB858500121A GB8500121D0 (en) 1985-01-03 1985-01-03 Microencapsulation of living cells

Publications (1)

Publication Number Publication Date
CA1258429A true CA1258429A (en) 1989-08-15

Family

ID=10572378

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000498218A Expired CA1258429A (en) 1985-01-03 1985-12-20 Microencapsulation of living cells

Country Status (6)

Country Link
EP (1) EP0188309B1 (esLanguage)
JP (1) JPS61209586A (esLanguage)
AT (1) ATE52913T1 (esLanguage)
CA (1) CA1258429A (esLanguage)
DE (1) DE3671368D1 (esLanguage)
GB (1) GB8500121D0 (esLanguage)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0152898B1 (en) * 1984-02-15 1990-01-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system(
NO166836C (no) * 1985-03-14 1991-09-11 Univ California Fremgangsmaate for behandling av et organtransplantat.
DE3871176D1 (de) * 1987-02-25 1992-06-25 Hoechst Ag Mikroenkapsulierung von biologisch aktivem material.
EP0299205B1 (en) * 1987-06-19 1992-04-15 Temple University - Of The Commonwealth System Higher Education Sustained release microcapsules and method for the production thereof
EP0301777A1 (en) * 1987-07-28 1989-02-01 Queen's University At Kingston Multiple membrane microencapsulation
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5201778A (en) * 1989-07-04 1993-04-13 Giovanni Brotzu Vascular prosthesis containing in the wall microcapsules, including hormone-producing cells
DK0454044T3 (da) * 1990-04-25 1996-04-22 Hoechst Ag Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof
US5149543A (en) * 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5545223A (en) * 1990-10-31 1996-08-13 Baxter International, Inc. Ported tissue implant systems and methods of using same
JP3508023B2 (ja) * 1990-10-31 2004-03-22 バクスター、インターナショナル、インコーポレイテッド 密接血管化埋め込み材料
US5713888A (en) * 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
EP0585368B1 (en) * 1991-04-25 1997-08-06 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5232712A (en) * 1991-06-28 1993-08-03 Brown University Research Foundation Extrusion apparatus and systems
US6773458B1 (en) 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
US5453278A (en) * 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
CA2140905A1 (en) * 1992-07-29 1994-01-30 Keith E. Dionne Use of pouch of implantation of living cells
FR2696658B1 (fr) * 1992-10-14 1994-11-18 Hospal Ind Procédé et dispositif d'encapsulation d'une substance, ainsi que capsule obtenue.
AU6243294A (en) * 1993-02-18 1994-09-14 New England Deaconess Hospital Corporation Implantable artificial organ
DE4312970A1 (de) * 1993-04-21 1994-10-27 Juergen Dr Schrezenmeir Mikrokapsel sowie Verfahren und Vorrichtung zu ihrer Herstellung
AU688776B2 (en) * 1993-06-23 1998-03-19 Brown University Research Foundation Method and apparatus for sealing implantable, membrane encapsulation devices
US5908623A (en) 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
JP4098355B2 (ja) * 1993-08-12 2008-06-11 ニューロテック ユーエスエー， インコーポレイテッド 遺伝的に改変された細胞を含む生体適合性免疫隔離カプセル
JPH08503715A (ja) * 1993-09-24 1996-04-23 バクスター、インターナショナル、インコーポレイテッド 埋め込み装置の血管化を促進するための方法
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US6156305A (en) * 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
DE4426396A1 (de) * 1994-07-26 1996-02-01 Ulrich Prof Dr Zimmermann Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form
US5674495A (en) * 1995-02-27 1997-10-07 Purdue Research Foundation Alginate-based vaccine compositions
EP0747046A3 (en) * 1995-05-19 1997-12-03 Baxter International Inc. Permeable immunoisolation membrane structures for implantation of cells in host tissue
US6287558B1 (en) 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
US7101575B2 (en) 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
PT1280521E (pt) 2000-05-12 2005-10-31 Pharmacia & Upjohn Co Llc Composicao de vacina, metodo para a sua preparacao, e metodo de vacinacao de vertebrados
ATE392203T1 (de) 2001-05-30 2008-05-15 Csir Verfahren zur verkapselung eines wirkstoffs
DE102004013637A1 (de) 2004-03-19 2005-10-13 Capsulution Nanoscience Ag Verfahren zur Herstellung von CS-Partikeln und Mikrokapseln unter Verwendung poröser Template sowie CS-Partikel und Mikrokapseln
PL405101A1 (pl) 2013-08-20 2015-03-02 Zachodniopomorski Uniwersytet Technologiczny W Szczecinie Sposób wytwarzania mikrokapsułek

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2453642A1 (fr) * 1979-04-12 1980-11-07 Sanofi Sa Compositions therapeutiques a usage oral et a liberation programmee du methanesulfonate de dihydroergotoxine
NO158284C (no) * 1981-03-13 1988-08-17 Damon Biotech Inc Fremgangsmaate for selektiv oppbrytning av en permeabel membran.

Also Published As

Publication number Publication date
EP0188309A3 (en) 1987-09-02
EP0188309B1 (en) 1990-05-23
EP0188309A2 (en) 1986-07-23
ATE52913T1 (de) 1990-06-15
DE3671368D1 (de) 1990-06-28
JPS61209586A (ja) 1986-09-17
GB8500121D0 (en) 1985-02-13
JPH0534946B2 (esLanguage) 1993-05-25

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