CA1255594A - Compositions and methods of enhancing transdermal and transmembrane penetration of topical and systemic agents - Google Patents

Compositions and methods of enhancing transdermal and transmembrane penetration of topical and systemic agents

Info

Publication number
CA1255594A
CA1255594A CA000483807A CA483807A CA1255594A CA 1255594 A CA1255594 A CA 1255594A CA 000483807 A CA000483807 A CA 000483807A CA 483807 A CA483807 A CA 483807A CA 1255594 A CA1255594 A CA 1255594A
Authority
CA
Canada
Prior art keywords
composition
compositions
topical
penetration
enhancing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000483807A
Other languages
English (en)
French (fr)
Inventor
Dorla Mirejovsky
Harun Takruri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Pharmaceuticals Inc filed Critical Allergan Pharmaceuticals Inc
Application granted granted Critical
Publication of CA1255594A publication Critical patent/CA1255594A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000483807A 1984-06-13 1985-06-12 Compositions and methods of enhancing transdermal and transmembrane penetration of topical and systemic agents Expired CA1255594A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/620,229 US4743588A (en) 1984-06-13 1984-06-13 Compositions and methods of enhancing transdermal and transmembrane penetration systemic agents
US620,229 1996-03-22

Publications (1)

Publication Number Publication Date
CA1255594A true CA1255594A (en) 1989-06-13

Family

ID=24485099

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000483807A Expired CA1255594A (en) 1984-06-13 1985-06-12 Compositions and methods of enhancing transdermal and transmembrane penetration of topical and systemic agents

Country Status (16)

Country Link
US (1) US4743588A (en, 2012)
EP (1) EP0164998A3 (en, 2012)
JP (1) JPS611623A (en, 2012)
KR (1) KR860000065A (en, 2012)
AU (1) AU582364B2 (en, 2012)
CA (1) CA1255594A (en, 2012)
DK (1) DK259485A (en, 2012)
EG (1) EG17345A (en, 2012)
FI (1) FI852331L (en, 2012)
GR (1) GR851421B (en, 2012)
HU (1) HU193774B (en, 2012)
IL (1) IL75488A (en, 2012)
NZ (1) NZ212368A (en, 2012)
PT (1) PT80625B (en, 2012)
ZA (1) ZA854365B (en, 2012)
ZW (1) ZW9985A1 (en, 2012)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837026A (en) * 1985-10-03 1989-06-06 Rajakhyaksha Vithal J Transdermal and systemic preparation and method
US5204339A (en) * 1986-01-31 1993-04-20 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
US4886545A (en) * 1986-01-31 1989-12-12 Nelson Research & Development Company Compositions comprising 1-substituted azacycloalkanes and their uses
AU7031887A (en) * 1986-01-31 1987-08-25 Nelson Research & Development Company Compositions comprising 1-substituted azacycloalkanes and their uses
DK277387A (da) * 1986-05-30 1987-12-01 Univ California Terapeutisk topikal sammensaetning mod en hyperprolifererende epithelsygdom
CA1308352C (en) * 1986-08-15 1992-10-06 James V. Peck Compositions comprising 1-oxohydrocarbyl-substituted azacyclohexanes
US4917896A (en) * 1986-08-15 1990-04-17 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agents
US4808414A (en) * 1986-09-29 1989-02-28 Nelson Research & Development Co. Amide penetration enhancers for transdermal delivery of systemic agents
ATE75620T1 (de) * 1986-11-19 1992-05-15 Whitby Research Inc Penetrationsverbesserer fuer die transdermale verabreichung von systemisch wirksamen arzneimitteln.
EP0268219A1 (en) * 1986-11-19 1988-05-25 Whitby Research Incorporated Penetration enhancers for transdermal delivery of systemic agents
US5112804A (en) * 1987-04-01 1992-05-12 Temple University Of The Commonwealth System Of Higher Education Pharmaceutical composition and method of intranasal administration
US4920101A (en) * 1987-09-30 1990-04-24 Nelson Research & Development Co. Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes
US4879275A (en) * 1987-09-30 1989-11-07 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agent
CA1334646C (en) * 1988-04-08 1995-03-07 James Vanolden Peck Transdermal penetration enhancers
JPH03505450A (ja) * 1988-06-30 1991-11-28 ジ・アップジョン・カンパニー 胃腸病用の経皮抗分泌剤
US5059603A (en) * 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
US5981591A (en) * 1992-12-04 1999-11-09 Mayor Pharmaceutical Laboratories, Inc. Sprayable analgesic composition and method of use
US6767925B1 (en) 1996-10-31 2004-07-27 Joseph A. Deihl Sprayable analgesic composition and method of use
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US20060002949A1 (en) * 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002959A1 (en) * 1996-11-14 2006-01-05 Government Of The United States Skin-sctive adjuvants for transcutaneous immuization
AU747041B2 (en) * 1997-11-10 2002-05-09 Strakan International Limited Penetration enhancing and irritation reducing systems
US20040258703A1 (en) * 1997-11-14 2004-12-23 The Government Of The Us, As Represented By The Secretary Of The Army Skin-active adjuvants for transcutaneous immunization
US6262117B1 (en) 1999-02-18 2001-07-17 Allergan Sales, Inc. Method and composition for treating acne
EP1165132B1 (en) * 1999-04-08 2011-10-19 Intercell USA, Inc. Dry formulation for transcutaneous immunization
DK1372708T3 (da) * 2001-02-13 2008-10-20 Us Gov Sec Army Vaccine til transkutan immunisering mod rejsediarre
US6521613B2 (en) 2001-04-10 2003-02-18 Allergan, Inc. Lactam compounds for penetration enhancement
WO2003028667A2 (en) * 2001-10-04 2003-04-10 Cellegy Pharmaceuticals, Inc. Semisolid topical hormonal compositions and methods for treatment
US20060222692A1 (en) * 2005-03-31 2006-10-05 Fairfield Clinical Trials Llc Method and compositions for transdermal administration of antimicrobial medications

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3223708A (en) * 1962-05-24 1965-12-14 Robert R Mod N-decanoyltetrahydroquinoline
US4316893A (en) * 1975-06-19 1982-02-23 Nelson Research & Development Co. Vehicle composition containing 1-substituted azacycloalkan-2-ones
DE3009546A1 (de) * 1980-03-13 1981-09-24 Henkel KGaA, 4000 Düsseldorf Desodorierende kosmetische zusammensetzungen

Also Published As

Publication number Publication date
DK259485A (da) 1985-12-14
AU4345285A (en) 1985-12-19
FI852331A7 (fi) 1985-12-14
EP0164998A3 (en) 1987-06-16
EP0164998A2 (en) 1985-12-18
FI852331A0 (fi) 1985-06-12
US4743588A (en) 1988-05-10
IL75488A (en) 1989-07-31
AU582364B2 (en) 1989-03-23
ZA854365B (en) 1986-05-28
ZW9985A1 (en) 1985-09-04
HUT38543A (en) 1986-06-30
EG17345A (en) 1991-03-30
NZ212368A (en) 1988-03-30
JPS611623A (ja) 1986-01-07
GR851421B (en, 2012) 1985-11-25
PT80625A (en) 1985-07-01
HU193774B (en) 1987-11-30
DK259485D0 (da) 1985-06-10
PT80625B (en) 1987-03-26
KR860000065A (ko) 1986-01-25
FI852331L (fi) 1985-12-14

Similar Documents

Publication Publication Date Title
CA1255594A (en) Compositions and methods of enhancing transdermal and transmembrane penetration of topical and systemic agents
US5082866A (en) Biodegradable absorption enhancers
US4980378A (en) Biodegradable absorption enhancers
US4837026A (en) Transdermal and systemic preparation and method
AU664178B2 (en) Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers
CA1306692C (en) Penetration enhancers for transdermal delivery of systemic agents
US3991203A (en) Vehicle composition containing 1-substituted azacyclopentan-2-ones
EP0257086B1 (en) Skinpenetration enhancing compositions
CA1146070A (en) Topical triethylenetetramine-containing pharmaceutical compositions and methods of use
US4424210A (en) Vehicle composition containing 1-substituted azacycloalkan-2-ones
CA1076028A (en) Vehicle compositions containing 1-n-dodecylazacycloheptan-2-one
US4415563A (en) Vehicle composition containing 1-substituted azacyclononan-2-ones
US4423040A (en) Vehicle composition containing 1-substituted azacyclohexan-2-ones
EP0267277B1 (en) Compositions comprising 1-substituted lactams
WO1988004938A1 (en) Heterocyclic compounds for transdermal use
EP0268220A2 (en) Penetration enhancers for transdermal delivery of systemic agents
US4820711A (en) Method for treating actinic keratosis with cytotoxic agents
US4849426A (en) Method for treating actinic keratosis with cytotoxic agents
US5162315A (en) Penetration enhancers
JP2782214B2 (ja) １‐オキソ‐またはチオヒドロカルビル置換アザシクロアルカンからなる組成物
RU2165265C2 (ru) Усилители абсорбции для фармацевтических композиций местного применения
US5108991A (en) Vehicle composition containing 1-substituted azacycloalkan-2-ones
EP0319486A2 (en) N-alkylamides of D,L and L(-)-carnitine having antibacterial activity, process for their preparation and pharmaceutical and cosmetic compositions containing same
US4845233A (en) Imidazolin-2-ones
EP0257063B1 (en) Compositions comprising 1-substituted azacycloalkanes and their uses

Legal Events

Date Code Title Description
MKEX Expiry