CA1226523A - Antiandrogen and antibiotic treatment of acne and pharmaceutical preparations therefor - Google Patents
Antiandrogen and antibiotic treatment of acne and pharmaceutical preparations thereforInfo
- Publication number
- CA1226523A CA1226523A CA000444482A CA444482A CA1226523A CA 1226523 A CA1226523 A CA 1226523A CA 000444482 A CA000444482 A CA 000444482A CA 444482 A CA444482 A CA 444482A CA 1226523 A CA1226523 A CA 1226523A
- Authority
- CA
- Canada
- Prior art keywords
- formulation
- series
- antibiotic
- androgen
- pack
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 56
- 206010000496 acne Diseases 0.000 title claims abstract description 56
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 48
- 230000002280 anti-androgenic effect Effects 0.000 title claims abstract description 28
- 239000000051 antiandrogen Substances 0.000 title claims abstract description 27
- 238000011282 treatment Methods 0.000 title abstract description 38
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 60
- 238000009472 formulation Methods 0.000 claims abstract description 54
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- 229960000978 cyproterone acetate Drugs 0.000 claims abstract description 48
- 239000002552 dosage form Substances 0.000 claims abstract description 36
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 9
- 230000027758 ovulation cycle Effects 0.000 claims abstract description 9
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- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 28
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- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 16
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- 230000004580 weight loss Effects 0.000 description 1
- HSYFJDYGOJKZCL-UHFFFAOYSA-L zinc;sulfite Chemical compound [Zn+2].[O-]S([O-])=O HSYFJDYGOJKZCL-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8237090 | 1982-12-31 | ||
| GB8237090 | 1982-12-31 | ||
| GB8310138 | 1983-04-14 | ||
| GB838310138A GB8310138D0 (en) | 1982-12-31 | 1983-04-14 | Antiandrogen and antibiotic treatment of acne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1226523A true CA1226523A (en) | 1987-09-08 |
Family
ID=26284814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000444482A Expired CA1226523A (en) | 1982-12-31 | 1983-12-30 | Antiandrogen and antibiotic treatment of acne and pharmaceutical preparations therefor |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0114003A1 (OSRAM) |
| AU (1) | AU565915B2 (OSRAM) |
| CA (1) | CA1226523A (OSRAM) |
| DK (1) | DK607583A (OSRAM) |
| GR (1) | GR79447B (OSRAM) |
| NZ (1) | NZ206745A (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3738620A1 (de) * | 1987-11-13 | 1989-05-24 | Luderschmidt Christoph | Verwendung von ethisterone zur topischen behandlung von akne oder androgenetischer alopezie |
| US5595985A (en) * | 1989-03-10 | 1997-01-21 | Endorecherche Inc. | Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia |
| US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
| AU5851690A (en) * | 1989-07-07 | 1991-02-06 | Endorecherche Inc. | Method of treatment of androgen-related diseases |
| ATE170753T1 (de) * | 1989-07-07 | 1998-09-15 | Endorecherche Inc | Androgenderivate zur hemming der aktivität der sexualsteroide |
| DE69033020T2 (de) * | 1989-07-07 | 1999-08-05 | Endorecherche Inc., Ste-Foy, Quebec | Kombinationstherapie zur prophylaxe und/oder behandlung benigner prostatahyperplasie |
| JPH07506575A (ja) * | 1992-05-21 | 1995-07-20 | アンドルシェルシュ・インコーポレイテッド | テストステロン５α−レダクターゼ活性の阻害剤 |
| DE4321957C2 (de) * | 1993-07-01 | 1995-09-28 | Marika Dr Med Ehrlich | Verwendung eines hormonalen Mittels zur Therapie der Akne |
| US5885601A (en) * | 1996-04-05 | 1999-03-23 | Family Health International | Use of macrolide antibiotics for nonsurgical female sterilization and endometrial ablation |
| US9000222B2 (en) | 2007-01-08 | 2015-04-07 | Androscience Corporation | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
| EP2993165B1 (en) | 2007-01-08 | 2018-06-27 | Allianz Pharmascience Ltd | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and use thereof |
| US8710272B2 (en) | 2007-01-08 | 2014-04-29 | Androscience Corporation | Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
| AU2008282749A1 (en) | 2007-07-31 | 2009-02-05 | Androscience Corporation | Compositions including androgen receptor degradation (ARD) enhancers and methods of prophylactic or therapeutic treatment of skin disorders and hair loss |
| EP2575816B1 (en) | 2010-05-28 | 2019-01-02 | Nexgen Dermatologics, Inc. | Combination therapy for skin disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3526M (fr) * | 1964-08-04 | 1965-09-06 | Charles Grupper | Composition thérapeutique pour le traitement de l'acné. |
| US4018918A (en) * | 1975-05-20 | 1977-04-19 | The Upjohn Company | Topical clindamycin preparations |
-
1983
- 1983-12-29 AU AU22973/83A patent/AU565915B2/en not_active Ceased
- 1983-12-29 GR GR73387A patent/GR79447B/el unknown
- 1983-12-30 EP EP83308031A patent/EP0114003A1/en active Pending
- 1983-12-30 CA CA000444482A patent/CA1226523A/en not_active Expired
- 1983-12-30 DK DK607583A patent/DK607583A/da not_active Application Discontinuation
-
1984
- 1984-01-05 NZ NZ20674584A patent/NZ206745A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK607583D0 (da) | 1983-12-30 |
| EP0114003A1 (en) | 1984-07-25 |
| AU565915B2 (en) | 1987-10-01 |
| DK607583A (da) | 1984-07-01 |
| GR79447B (OSRAM) | 1984-10-30 |
| AU2297383A (en) | 1984-07-05 |
| NZ206745A (en) | 1987-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |