CA1225930A - Metal chelate conjugated monoclonal antibodies - Google Patents
Metal chelate conjugated monoclonal antibodiesInfo
- Publication number
- CA1225930A CA1225930A CA000429760A CA429760A CA1225930A CA 1225930 A CA1225930 A CA 1225930A CA 000429760 A CA000429760 A CA 000429760A CA 429760 A CA429760 A CA 429760A CA 1225930 A CA1225930 A CA 1225930A
- Authority
- CA
- Canada
- Prior art keywords
- chelate
- solution
- metal
- radiometal
- monoclonal antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/386,109 US4454106A (en) | 1982-06-07 | 1982-06-07 | Use of metal chelate conjugated monoclonal antibodies |
| US06/386,110 US4472509A (en) | 1982-06-07 | 1982-06-07 | Metal chelate conjugated monoclonal antibodies |
| US386,110 | 1982-06-07 | ||
| US386,109 | 1989-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1225930A true CA1225930A (en) | 1987-08-25 |
Family
ID=27011278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000429760A Expired CA1225930A (en) | 1982-06-07 | 1983-06-06 | Metal chelate conjugated monoclonal antibodies |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2599705B2 (is) |
| CA (1) | CA1225930A (is) |
| DE (1) | DE3320560A1 (is) |
| FR (1) | FR2527928B1 (is) |
| GB (1) | GB2122641B (is) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
| CA1260827A (en) * | 1984-08-31 | 1989-09-26 | Richard C. Siegel | Antibody-metal ion complexes |
| US5393512A (en) * | 1985-01-14 | 1995-02-28 | Vanderheyden; Jean-Luc | Stable therapeutic radionuclide compositions and methods for preparation thereof |
| US4824986A (en) * | 1985-04-26 | 1989-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metal chelate protein conjugate |
| ATE89743T1 (de) * | 1986-08-18 | 1993-06-15 | Dow Chemical Co | Conjugate dichter sterne. |
| AU619218B2 (en) * | 1987-11-06 | 1992-01-23 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| JPH01176000A (ja) * | 1987-12-30 | 1989-07-12 | Nippon Mejifuijitsukusu Kk | 放射性医薬品とその調製用高分子化合物 |
| US5972656A (en) * | 1989-03-14 | 1999-10-26 | Bionebraska, Inc. | Mercury binding polypeptides and nucleotides coding therefore |
| US5639624A (en) * | 1989-03-14 | 1997-06-17 | Board Of Regents Of The University Of Nebraska | Monoclonal antibodies specific for metallic cations and method therefor |
| CA2066779A1 (en) * | 1989-09-22 | 1991-03-23 | Jean-Luc Vanderheyden | Stable therapeutic radionuclide compositions and methods for preparation thereof |
| US5244816A (en) * | 1989-10-11 | 1993-09-14 | Akzo N.V. | Method for purifying chelator conjugated compounds |
| CA2100709C (en) * | 1992-07-27 | 2004-03-16 | Maurits W. Geerlings | Method and means for site directed therapy |
| US6111079A (en) * | 1995-06-05 | 2000-08-29 | Bionebraska, Inc. | Lead binding polypeptides and nucleotides coding therefore |
| ES2183904T3 (es) * | 1996-11-15 | 2003-04-01 | Euratom | Metodo extracorporeo para el tratamiento de celulas sanguineas. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH583036A5 (is) * | 1972-05-12 | 1976-12-31 | Hoffmann La Roche | |
| JPS5857149B2 (ja) * | 1975-12-25 | 1983-12-19 | スギウラ マモル | エル − アミノサンサンカコウソノセイセイホウ |
| US4311688A (en) * | 1979-10-29 | 1982-01-19 | Serono Laboratories Inc. | Composition and method for cancer detection in humans |
| US4421735A (en) * | 1980-04-17 | 1983-12-20 | The Massachusetts General Hospital | Radiolabeled diagnostic compositions and method for making the same |
| ES8404857A1 (es) * | 1981-10-27 | 1984-05-16 | Hybritech Inc | Un procedimiento para preparar un anticuerpo monoclonal para un antigeno asociado a un tumor. |
| US4666697A (en) * | 1982-12-08 | 1987-05-19 | Nihon Medi-Physics Co., Ltd. | Radioactive diagnostic agent |
-
1983
- 1983-06-06 GB GB08315483A patent/GB2122641B/en not_active Expired
- 1983-06-06 CA CA000429760A patent/CA1225930A/en not_active Expired
- 1983-06-07 DE DE19833320560 patent/DE3320560A1/de active Granted
- 1983-06-07 JP JP58101593A patent/JP2599705B2/ja not_active Expired - Lifetime
- 1983-06-07 FR FR8309437A patent/FR2527928B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB8315483D0 (en) | 1983-07-13 |
| DE3320560C2 (is) | 1993-09-16 |
| DE3320560A1 (de) | 1984-02-09 |
| JPS5946227A (ja) | 1984-03-15 |
| FR2527928A1 (fr) | 1983-12-09 |
| JP2599705B2 (ja) | 1997-04-16 |
| GB2122641A (en) | 1984-01-18 |
| FR2527928B1 (fr) | 1989-09-22 |
| GB2122641B (en) | 1986-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |