CA1225930A - Metal chelate conjugated monoclonal antibodies - Google Patents

Metal chelate conjugated monoclonal antibodies

Info

Publication number
CA1225930A
CA1225930A CA000429760A CA429760A CA1225930A CA 1225930 A CA1225930 A CA 1225930A CA 000429760 A CA000429760 A CA 000429760A CA 429760 A CA429760 A CA 429760A CA 1225930 A CA1225930 A CA 1225930A
Authority
CA
Canada
Prior art keywords
chelate
solution
metal
radiometal
monoclonal antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000429760A
Other languages
English (en)
French (fr)
Inventor
Otto A. Gansow
Mette Strand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/386,110 external-priority patent/US4472509A/en
Priority claimed from US06/386,109 external-priority patent/US4454106A/en
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of CA1225930A publication Critical patent/CA1225930A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C07K16/112—
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Radiation-Therapy Devices (AREA)
CA000429760A 1982-06-07 1983-06-06 Metal chelate conjugated monoclonal antibodies Expired CA1225930A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US386,110 1982-06-07
US06/386,110 US4472509A (en) 1982-06-07 1982-06-07 Metal chelate conjugated monoclonal antibodies
US06/386,109 US4454106A (en) 1982-06-07 1982-06-07 Use of metal chelate conjugated monoclonal antibodies
US386,109 1989-07-28

Publications (1)

Publication Number Publication Date
CA1225930A true CA1225930A (en) 1987-08-25

Family

ID=27011278

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000429760A Expired CA1225930A (en) 1982-06-07 1983-06-06 Metal chelate conjugated monoclonal antibodies

Country Status (5)

Country Link
JP (1) JP2599705B2 (enExample)
CA (1) CA1225930A (enExample)
DE (1) DE3320560A1 (enExample)
FR (1) FR2527928B1 (enExample)
GB (1) GB2122641B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US5393512A (en) * 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
DE3786000T3 (de) * 1986-08-18 1997-08-21 Dow Chemical Co Conjugate dichter Sterne.
AU619218B2 (en) * 1987-11-06 1992-01-23 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
JPH01176000A (ja) * 1987-12-30 1989-07-12 Nippon Mejifuijitsukusu Kk 放射性医薬品とその調製用高分子化合物
US5639624A (en) * 1989-03-14 1997-06-17 Board Of Regents Of The University Of Nebraska Monoclonal antibodies specific for metallic cations and method therefor
US5972656A (en) * 1989-03-14 1999-10-26 Bionebraska, Inc. Mercury binding polypeptides and nucleotides coding therefore
CA2066779A1 (en) * 1989-09-22 1991-03-23 Jean-Luc Vanderheyden Stable therapeutic radionuclide compositions and methods for preparation thereof
US5244816A (en) * 1989-10-11 1993-09-14 Akzo N.V. Method for purifying chelator conjugated compounds
CA2100709C (en) * 1992-07-27 2004-03-16 Maurits W. Geerlings Method and means for site directed therapy
US6111079A (en) * 1995-06-05 2000-08-29 Bionebraska, Inc. Lead binding polypeptides and nucleotides coding therefore
ATE223237T1 (de) * 1996-11-15 2002-09-15 Euratom Ex-corpore verfahren zur behändlung von blut- zellen
JP2024112356A (ja) * 2023-02-08 2024-08-21 Ｊｆｅエンジニアリング株式会社 放射性核種標識薬剤の精製方法
JP2024112505A (ja) * 2023-02-08 2024-08-21 Ｊｆｅエンジニアリング株式会社 放射性核種標識薬剤の精製方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH583036A5 (enExample) * 1972-05-12 1976-12-31 Hoffmann La Roche
JPS5857149B2 (ja) * 1975-12-25 1983-12-19 スギウラ マモル エル − アミノサンサンカコウソノセイセイホウ
US4311688A (en) * 1979-10-29 1982-01-19 Serono Laboratories Inc. Composition and method for cancer detection in humans
US4421735A (en) * 1980-04-17 1983-12-20 The Massachusetts General Hospital Radiolabeled diagnostic compositions and method for making the same
NO169947C (no) * 1981-10-27 1992-08-26 Hybritech Inc Fremgangsmaate for fremstilling av et monoklonalt antistoff til et tumorassosiert antigen
US4666697A (en) * 1982-12-08 1987-05-19 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic agent

Also Published As

Publication number Publication date
DE3320560C2 (enExample) 1993-09-16
GB2122641A (en) 1984-01-18
FR2527928B1 (fr) 1989-09-22
GB8315483D0 (en) 1983-07-13
FR2527928A1 (fr) 1983-12-09
GB2122641B (en) 1986-08-06
JPS5946227A (ja) 1984-03-15
JP2599705B2 (ja) 1997-04-16
DE3320560A1 (de) 1984-02-09

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Legal Events

Date Code Title Description
MKEX Expiry