CA1224460A - ANTI-LEUKEMIC .beta.-GLYCOSYL C-NUCLEOSIDES - Google Patents

ANTI-LEUKEMIC .beta.-GLYCOSYL C-NUCLEOSIDES

Info

Publication number
CA1224460A
CA1224460A CA000408495A CA408495A CA1224460A CA 1224460 A CA1224460 A CA 1224460A CA 000408495 A CA000408495 A CA 000408495A CA 408495 A CA408495 A CA 408495A CA 1224460 A CA1224460 A CA 1224460A
Authority
CA
Canada
Prior art keywords
beta
pyrimidine
ribofuranosyl
amino
thieno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000408495A
Other languages
English (en)
French (fr)
Inventor
Robert S. Klein
Mu-Iii Lim
Wuyun Ren
Joseph H. Burchenal
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Application granted granted Critical
Publication of CA1224460A publication Critical patent/CA1224460A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA000408495A 1981-07-31 1982-07-30 ANTI-LEUKEMIC .beta.-GLYCOSYL C-NUCLEOSIDES Expired CA1224460A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28884881A 1981-07-31 1981-07-31
US288,848 1981-07-31

Publications (1)

Publication Number Publication Date
CA1224460A true CA1224460A (en) 1987-07-21

Family

ID=23108919

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000408495A Expired CA1224460A (en) 1981-07-31 1982-07-30 ANTI-LEUKEMIC .beta.-GLYCOSYL C-NUCLEOSIDES

Country Status (4)

Country Link
EP (1) EP0071227B1 (enExample)
JP (1) JPS5826888A (enExample)
CA (1) CA1224460A (enExample)
DE (1) DE3277623D1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0611698B2 (ja) * 1984-12-19 1994-02-16 大正製薬株式会社 貼付剤
US4880784A (en) * 1987-12-21 1989-11-14 Brigham Young University Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
ES2167710T3 (es) 1996-02-07 2002-05-16 Janssen Pharmaceutica Nv Tiofenopirimidinas.
ID23978A (id) 1997-11-11 2000-06-14 Pfizer Prod Inc Turunan-turunan tienopirimidin dan tienopiridin yang berguna sebagai zat-zat anti kangker
PT1287001E (pt) 2000-06-06 2004-12-31 Pfizer Prod Inc Derivados de tiofeno uteis como agentes anticancerigenos
GB2375482A (en) * 2001-05-15 2002-11-20 Maria Stammers Pad scenter and perfumer device
CA2536887C (en) * 2003-08-26 2012-03-06 Teijin Pharma Limited Pyrrolopyrimidinone derivatives
US7557113B2 (en) 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
AU2005254057B2 (en) * 2004-06-15 2011-02-17 Isis Pharmaceuticals, Inc. C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
EP1814561A4 (en) * 2004-10-29 2012-12-19 Biocryst Pharm Inc THEROPUTICAL FUROPYRIMIDINES AND THIENOPYRIMIDINES
EP1863500A2 (en) 2005-03-29 2007-12-12 Biocryst Pharmaceuticals, Inc. Hepatitis c therapies
WO2008082839A2 (en) * 2006-12-29 2008-07-10 Abbott Laboratories Pim kinase inhibitors as cancer chemotherapeutics
KR20240050362A (ko) 2021-08-20 2024-04-18 시오노기 앤드 컴파니, 리미티드 바이러스 증식 억제 작용을 갖는 뉴클레오사이드 유도체 및 그들의 프로드러그

Also Published As

Publication number Publication date
EP0071227A1 (en) 1983-02-09
DE3277623D1 (en) 1987-12-17
EP0071227B1 (en) 1987-11-11
JPS5826888A (ja) 1983-02-17
JPH046715B2 (enExample) 1992-02-06

Similar Documents

Publication Publication Date Title
US4584369A (en) Anti-leukemic beta-glycosyl C-nucleosides
US5502187A (en) Pharmaceutically active bicyclic-heterocyclic amines
CA1224460A (en) ANTI-LEUKEMIC .beta.-GLYCOSYL C-NUCLEOSIDES
EP0874853B1 (en) Process for preparation of cefdinir
US4543255A (en) Carbocyclic analogs of purine 2'-deoxyribofuranosides
EP0166054B1 (en) 3-aminopyrazolo(3,4-d)pyrimidine derivatives and production thereof
Cusack et al. Purines, pyrimidines, and imidazoles. Part XL. A new synthesis of a D-ribofuranosylamine derivative and its use in the synthesis of pyrimidine and imidazole nucleosides
Akimoto et al. Synthesis of queuine, the base of naturally occurring hypermodified nucleoside (queuosine), and its analogues
EP0089055B1 (en) Deazapurine derivatives
US3721664A (en) Preparation of 5-cytosine nucleosides
US4528288A (en) Substituted triazolo[1,5-c]pyrimidines
Seita et al. The synthesis of nucleoside and nucleotide analogs
CA2164918C (en) Thiol compounds
US4432990A (en) 5-Aminoimidazoles as immunoregulants
US4060616A (en) Purine derivatives with repeating unit
ZA200407821B (en) Compounds useful in preparing camptothecin derivatives.
Hosmane et al. The synthesis of ring‐expanded analogues of xanthine containing the imidazo [4, 5‐e][1, 4] diazepine ring system
Komkov et al. 5-Acetyl-6-amino-4-methylthio-2-phenylpyrimidine and its use in the synthesis of functionalized pyrido [2, 3-d] pyrimidines and pyrimido-[4, 5-d] pyrimidines
US4329460A (en) Uracil derivatives and production thereof
EP0416605B1 (en) Novel oxetanocin derivatives and their salts as well as use thereof
Stoss et al. Novel pyrimidine and pyrimido [1, 2‐a] pyrimidine derivatives. By‐products of a guanidine based thymine synthesis
US5703224A (en) Antiviral c-nucleoside derivatives
CA1269368A (en) N-glycolylneuraminic acid derivative
US4464531A (en) 4-Carbamoylimidazolium-5-olate derivatives
US4591588A (en) Triazolo[1,5-c]pyrimidines and bronchodilation use thereof

Legal Events

Date Code Title Description
MKEX Expiry