CA1210718A - Continuous bioreactor and process - Google Patents
Continuous bioreactor and processInfo
- Publication number
- CA1210718A CA1210718A CA000470544A CA470544A CA1210718A CA 1210718 A CA1210718 A CA 1210718A CA 000470544 A CA000470544 A CA 000470544A CA 470544 A CA470544 A CA 470544A CA 1210718 A CA1210718 A CA 1210718A
- Authority
- CA
- Canada
- Prior art keywords
- membrane
- nutrient medium
- spirally
- interior
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 76
- 230000008569 process Effects 0.000 title claims abstract description 67
- 239000012528 membrane Substances 0.000 claims abstract description 150
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 90
- 244000005700 microbiome Species 0.000 claims abstract description 66
- 239000000463 material Substances 0.000 claims abstract description 42
- 239000001963 growth medium Substances 0.000 claims abstract description 23
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 20
- 230000001902 propagating effect Effects 0.000 claims abstract description 15
- 239000002609 medium Substances 0.000 claims description 81
- 235000015097 nutrients Nutrition 0.000 claims description 81
- 235000013379 molasses Nutrition 0.000 claims description 42
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 30
- 239000001301 oxygen Substances 0.000 claims description 30
- 229910052760 oxygen Inorganic materials 0.000 claims description 30
- 239000007789 gas Substances 0.000 claims description 25
- 239000007787 solid Substances 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 12
- 239000011148 porous material Substances 0.000 claims description 11
- 230000000644 propagated effect Effects 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 7
- 239000012535 impurity Substances 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 abstract description 11
- 230000001976 improved effect Effects 0.000 abstract description 10
- 208000027418 Wounds and injury Diseases 0.000 description 30
- 239000012466 permeate Substances 0.000 description 13
- 239000000047 product Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 7
- 229930006000 Sucrose Natural products 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 230000012010 growth Effects 0.000 description 7
- 239000005720 sucrose Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 206010003402 Arthropod sting Diseases 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 238000010924 continuous production Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- 210000005253 yeast cell Anatomy 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 238000010923 batch production Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 235000016068 Berberis vulgaris Nutrition 0.000 description 2
- 241000335053 Beta vulgaris Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 238000010564 aerobic fermentation Methods 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 241000219289 Silene Species 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 235000021550 forms of sugar Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000012913 medium supplement Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/80—Elimination or reduction of contamination by undersired ferments, e.g. aseptic cultivation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/813—Continuous fermentation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/818—Aeration or oxygen transfer technique
Landscapes
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US568,084 | 1984-01-04 | ||
| US06/568,084 US4764471A (en) | 1984-01-04 | 1984-01-04 | Continuous bioreactor and process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1210718A true CA1210718A (en) | 1986-09-02 |
Family
ID=24269869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000470544A Expired CA1210718A (en) | 1984-01-04 | 1984-12-19 | Continuous bioreactor and process |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4764471A (en, 2012) |
| EP (1) | EP0148764A3 (en, 2012) |
| JP (1) | JPS60227671A (en, 2012) |
| AU (1) | AU584596B2 (en, 2012) |
| BR (1) | BR8500006A (en, 2012) |
| CA (1) | CA1210718A (en, 2012) |
| ZA (1) | ZA8410146B (en, 2012) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4806484A (en) * | 1987-08-07 | 1989-02-21 | Igb Products, Ltd. | Perfusion airlift bioreactor |
| DE68921974T2 (de) * | 1988-05-23 | 1995-08-03 | Univ Minnesota | Bioreaktor. |
| US5605835A (en) * | 1988-05-23 | 1997-02-25 | Regents Of The University Of Minnesota | Bioreactor device with application as a bioartificial liver |
| US4954440A (en) * | 1988-06-16 | 1990-09-04 | The Standard Oil Company | Production of polysaccharides from filamentous fungi |
| CA1307225C (en) * | 1988-07-19 | 1992-09-08 | David W. Armstrong | Cell culture bioreactor |
| US5126238A (en) * | 1990-02-15 | 1992-06-30 | Unisyn Fibertec Corporation | Hollow fiber cell propagation system and method |
| US5656421A (en) * | 1990-02-15 | 1997-08-12 | Unisyn Technologies, Inc. | Multi-bioreactor hollow fiber cell propagation system and method |
| US5164605A (en) * | 1991-08-14 | 1992-11-17 | The Babcock & Wilcox Company | Fiber optic displacement sensor using fiber optic coil |
| US6916652B2 (en) * | 1995-03-28 | 2005-07-12 | Kinetic Biosystems, Inc. | Biocatalyst chamber encapsulation system for bioremediation and fermentation |
| US6133019A (en) * | 1995-03-28 | 2000-10-17 | Kinetic Biosystems, Inc. | Centrifugal fermentation process |
| US20050266548A1 (en) * | 1995-03-28 | 2005-12-01 | Kbi Biopharma, Inc. | Biocatalyst chamber encapsulation system for bioremediation and fermentation with improved rotor |
| US6214617B1 (en) | 1995-03-28 | 2001-04-10 | Kinetic Biosystems, Inc. | Centrifugal fermentation process |
| US5622819A (en) * | 1995-03-28 | 1997-04-22 | Kinetic Biosystems, Inc. | Centrifugal fermentation process |
| US6660509B1 (en) | 1995-03-28 | 2003-12-09 | Kinetic Biosystems, Inc. | Methods and devices for remediation and fermentation |
| US7186428B1 (en) * | 1999-11-23 | 2007-03-06 | Miller Brewing Company | Method of oxygenating yeast slurry using hydrophobic polymer membranes |
| US6703217B2 (en) | 2000-01-31 | 2004-03-09 | Kinetic Biosystems, Inc. | Methods and devices for remediation and fermentation |
| ES2389618T3 (es) | 2007-04-16 | 2012-10-29 | Momenta Pharmaceuticals, Inc. | Productos de glucoproteínas definidas y métodos relacionados |
| US20080299624A1 (en) * | 2007-06-01 | 2008-12-04 | Edward Heslop | Continuous fermentation apparatus and method |
| WO2012003402A2 (en) | 2010-07-01 | 2012-01-05 | Heliobiosys, Inc. | Compositions and methods for culturing microorganisms |
| CN113501575A (zh) * | 2021-06-23 | 2021-10-15 | 武汉新烽光电股份有限公司 | 快速bod检测原位生物膜载体反应器 |
| EP4480960A1 (en) | 2023-06-22 | 2024-12-25 | AATEC Medical GmbH | A recombinant human alpha-1 antitrypsin glycoprotein |
| WO2024261179A1 (en) | 2023-06-22 | 2024-12-26 | Aatec Medical Gmbh | Recombinant aat from yeast to treat bacterial respiratory infections |
| WO2024261142A1 (en) | 2023-06-22 | 2024-12-26 | Aatec Medical Gmbh | A recombinant human alpha-1 antitrypsin glycoprotein |
| EP4480493A1 (en) | 2023-06-22 | 2024-12-25 | AATEC Medical GmbH | A recombinant human alpha-1 antitrypsin glycoprotein for treating non-viral inflammatory diseases of the lung |
| WO2024261171A1 (en) | 2023-06-22 | 2024-12-26 | Aatec Medical Gmbh | Recombinant aat from yeast to treat transplants |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1687561A (en) * | 1923-05-08 | 1928-10-16 | Fleischmann Co | Method of clarifying cane molasses for the growing of yeast |
| US3417870A (en) * | 1965-03-22 | 1968-12-24 | Gulf General Atomic Inc | Reverse osmosis purification apparatus |
| US3997396A (en) * | 1973-07-02 | 1976-12-14 | Monsanto Company | Method for the in vitro propagation and maintenance of cells |
| US3911140A (en) * | 1973-07-02 | 1975-10-07 | Milk Marketing Board | Preparation of concentrated starter cultures |
| SE387657B (sv) * | 1973-07-09 | 1976-09-13 | Alfa Laval Ab | Sett vid kontinuerlig jesning, varvid efter jesningen separation sker genom centrifugering i tre komponenter, nemligen odlingsvetska, levande cellmassa och fororeningar |
| JPS5912278B2 (ja) * | 1976-04-01 | 1984-03-22 | 三井製糖株式会社 | 甘庶汁から栄養糖を製造する方法 |
| US4218538A (en) * | 1977-12-07 | 1980-08-19 | Inpro, Inc. | Two staged continuous fermentation process for production of heteropolysaccharide |
| MA18556A1 (fr) * | 1978-08-04 | 1980-04-01 | Lesaffre & Cie | Levure seche active de panification et souche permettant de l'obtenir |
| DE2940446C2 (de) * | 1979-10-05 | 1982-07-08 | B. Braun Melsungen Ag, 3508 Melsungen | Züchtung von tierischen Zellen in Suspensions- und Monolayerkulturen in Fermentationsgefäßen |
| US4442206A (en) * | 1980-08-21 | 1984-04-10 | Stanford University | Method of using isotropic, porous-wall polymeric membrane, hollow-fibers for culture of microbes |
| GB2110112A (en) * | 1981-04-13 | 1983-06-15 | Biomedical Eng Inc | Method and apparatus for high-efficiency ultrafiltration of complex fluids |
| US4416993A (en) * | 1981-06-11 | 1983-11-22 | Mcleod & Miller (Engineers) Limited | Apparatus with semi-permeable membrane, and method for cultivating micro-organisms |
| US4379845A (en) * | 1981-07-23 | 1983-04-12 | Nabisco Brands, Inc. | Yeast process and product |
| CA1188246A (en) * | 1981-08-31 | 1985-06-04 | Jerry L. Gregory | Immobilized microbe recycle apparatus |
| CH647547A5 (de) * | 1982-02-12 | 1985-01-31 | Chemap Ag | Verfahren und vorrichtung zum zuechten von mikroorganismen. |
| US4544637A (en) * | 1982-09-14 | 1985-10-01 | Igi Biotechnology, Inc. | Culture media from clarified diary whey lactose permeates |
-
1984
- 1984-01-04 US US06/568,084 patent/US4764471A/en not_active Expired - Fee Related
- 1984-12-19 CA CA000470544A patent/CA1210718A/en not_active Expired
- 1984-12-20 AU AU36967/84A patent/AU584596B2/en not_active Ceased
- 1984-12-28 ZA ZA8410146A patent/ZA8410146B/xx unknown
- 1984-12-31 JP JP59282148A patent/JPS60227671A/ja active Granted
-
1985
- 1985-01-03 EP EP85300037A patent/EP0148764A3/en not_active Withdrawn
- 1985-01-03 BR BR8500006A patent/BR8500006A/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0148764A2 (en) | 1985-07-17 |
| US4764471A (en) | 1988-08-16 |
| JPS6151870B2 (en, 2012) | 1986-11-11 |
| AU3696784A (en) | 1985-07-11 |
| AU584596B2 (en) | 1989-06-01 |
| ZA8410146B (en) | 1985-08-28 |
| BR8500006A (pt) | 1985-08-13 |
| EP0148764A3 (en) | 1988-09-28 |
| JPS60227671A (ja) | 1985-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |