CA1210348A - Microbiologically produced d-2-hydroxy-4-methyl- pentanoic acid dehydrogenase, process for producing same, and its use - Google Patents

Microbiologically produced d-2-hydroxy-4-methyl- pentanoic acid dehydrogenase, process for producing same, and its use

Info

Publication number
CA1210348A
CA1210348A CA000456000A CA456000A CA1210348A CA 1210348 A CA1210348 A CA 1210348A CA 000456000 A CA000456000 A CA 000456000A CA 456000 A CA456000 A CA 456000A CA 1210348 A CA1210348 A CA 1210348A
Authority
CA
Canada
Prior art keywords
acid
hydroxy
methyl
keto
pentanoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000456000A
Other languages
English (en)
French (fr)
Inventor
Wolfgang Leuchtenberger
Werner Hummel
Maria-Regina Kula
Horst Schutte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Evonik Operations GmbH
Original Assignee
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Zentrum fuer Infektionsforschung HZI GmbH, Degussa GmbH filed Critical Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Application granted granted Critical
Publication of CA1210348A publication Critical patent/CA1210348A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/853—Lactobacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/853—Lactobacillus
    • Y10S435/856—Lactobacillus casei

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA000456000A 1983-06-07 1984-06-06 Microbiologically produced d-2-hydroxy-4-methyl- pentanoic acid dehydrogenase, process for producing same, and its use Expired CA1210348A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3320495.0 1983-06-07
DE19833320495 DE3320495A1 (de) 1983-06-07 1983-06-07 Mikrobiologisch hergestellte d-2-hydroxy-4-methylpentansaeure-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung

Publications (1)

Publication Number Publication Date
CA1210348A true CA1210348A (en) 1986-08-26

Family

ID=6200840

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000456000A Expired CA1210348A (en) 1983-06-07 1984-06-06 Microbiologically produced d-2-hydroxy-4-methyl- pentanoic acid dehydrogenase, process for producing same, and its use

Country Status (6)

Country Link
US (1) US4609623A (2)
EP (1) EP0130288B1 (2)
JP (1) JPS6012975A (2)
CA (1) CA1210348A (2)
DE (2) DE3320495A1 (2)
DK (1) DK262784A (2)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3536662A1 (de) * 1985-10-15 1987-05-27 Degussa Mikrobiologisch hergestellte d(-)-mandelat-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung
JP2752754B2 (ja) * 1988-02-08 1998-05-18 ダイセル化学工業株式会社 光学活性２―ヒドロキシ―４―フェニル酪酸の製造法
US5256552A (en) * 1988-02-08 1993-10-26 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy-4-phenylbutyric acid
WO1989007648A1 (fr) * 1988-02-12 1989-08-24 Daicel Chemical Industries, Ltd. Procede de preparation de derives de l'acide 2-hydroxy optiquement actifs
US5371014A (en) * 1988-02-12 1994-12-06 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor
US5264347A (en) * 1988-09-16 1993-11-23 Kernforschungsanlage Juelich Gmbh Method for the determination of α-ketoisocaproate in biological samples using D-α-hydroxyisocaproic dehydrogenase from lactobacillus casei
DE3831450A1 (de) * 1988-09-16 1990-03-22 Kernforschungsanlage Juelich Verfahren zur bestimmung von (alpha)-ketoisocaproat in biologischen proben und dafuer geeigneter analysensatz
GB9413710D0 (en) * 1994-07-07 1994-08-24 Genzyme Ltd Chiral synthesis
JP4154182B2 (ja) * 2002-07-16 2008-09-24 ダイセル化学工業株式会社 α−ケト酸還元酵素、その製造方法、およびこれを利用した光学活性α−ヒドロキシ酸の製造方法
KR101757785B1 (ko) 2016-11-15 2017-07-14 한국식품연구원 2-하이드록시아이소카프로익 에시드(2-hydroxyisocaproic acid) 생성능이 우수한 류코노스톡 락티스 WIKIM48 및 이를 포함하는 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628009A5 (de) * 1977-07-26 1982-02-15 Hoffmann La Roche Verfahren zur herstellung von optisch aktiven alpha-hydroxycarbonsaeuren.
DE2841414C2 (de) * 1978-09-22 1980-04-03 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von an Makromoleküle gebundenen, ein Adeninringsystem enthaltenden Koenzymen
DE2930087A1 (de) * 1979-07-25 1981-02-26 Biotechnolog Forschung Gmbh Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden alpha -hydroxycarbonsaeuren
EP0103210B1 (de) * 1982-09-14 1987-11-25 Degussa Aktiengesellschaft L-2-Hydroxy-4-methylpentansäure-Dehydrogenase, Verfahren zu ihrer Gewinnung und ihre Verwendung

Also Published As

Publication number Publication date
DK262784D0 (da) 1984-05-28
EP0130288A3 (en) 1985-10-02
US4609623A (en) 1986-09-02
JPS6012975A (ja) 1985-01-23
EP0130288B1 (de) 1988-03-02
EP0130288A2 (de) 1985-01-09
DK262784A (da) 1984-12-08
DE3469565D1 (en) 1988-04-07
DE3320495A1 (de) 1984-12-13
JPH0127717B2 (2) 1989-05-30

Similar Documents

Publication Publication Date Title
JP3672307B2 (ja) 新規ケトエステル‐還元酵素，その製造方法及びこれを酵素酸化還元反応に使用する方法
CA1210348A (en) Microbiologically produced d-2-hydroxy-4-methyl- pentanoic acid dehydrogenase, process for producing same, and its use
Hummel et al. Large scale production of D-lactate dehydrogenase for the stereospecific reduction of pyruvate and phenylpyruvate
US5024945A (en) Process for obtaining sarcosine oxidase from microorganisms
US4590161A (en) Microbiologically produced L-phenylalanine-dehydrogenase, process for its recovery and use
US5416019A (en) Rhodococcus microorganisms that produce phenylalanine dehydroganase
Yang et al. Isolation and characterization of two rubredoxins from Clostridium thermoaceticum
US4530903A (en) L-2-hydroxy-4-methylpentanoic acid-dehydrogenase, process for obtaining it and its use
EP0954571B1 (en) Biocatalysts with amine acylase activity
US4824781A (en) Microbiologically produced d(-)-mandelate-dehydrogenase process for obtaining it and its use
US4342827A (en) Production of enzymes
US5234827A (en) Enzymatic process for manufacturing formaldehyde and hydrogen peroxide
US5627065A (en) DNA fragment containing a gene encoding creatinine amidohydrolase
US5164314A (en) Microbiologically-prepared diacetyl reductase
US5019505A (en) Enzymes having alpha-glycerol-3-phosphate oxidase activity, production and use thereof
JPS6031477B2 (ja) Ｄ↓−アミノアシラ−ゼ及びその製造方法
JPS59179075A (ja) ペルオキシダ−ゼの製造法
JPS6243671B2 (2)
US5610045A (en) Producing a high content of acetate kinase using bacillus stearothermophilus
US4877734A (en) Microbiologically produced α-acetylamino cinnamic acid acylase, method of its production and its use
FR2472608A1 (fr) Nouvelle glucose-6-phosphate-deshydrogenase, son procede de preparation et compositions coenzymatiques la contenant
JPH09247A (ja) Ｄ−乳酸脱水素酵素およびその製造法
JPS6248380A (ja) セフアロスポリンｃアシラ−ゼの製造法
Furuyoshi et al. Occurrence of a new enzyme, meso-tartrate dehydratase of Pseudomonas putida
RU2032743C1 (ru) Способ получения дрожжевой алкогольоксидазы

Legal Events

Date Code Title Description
MKEX Expiry