CA1187754A - Medical inhalation devices - Google Patents

Medical inhalation devices

Info

Publication number
CA1187754A
CA1187754A CA000409304A CA409304A CA1187754A CA 1187754 A CA1187754 A CA 1187754A CA 000409304 A CA000409304 A CA 000409304A CA 409304 A CA409304 A CA 409304A CA 1187754 A CA1187754 A CA 1187754A
Authority
CA
Canada
Prior art keywords
housing
outlet
valve
aerosol container
partition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000409304A
Other languages
French (fr)
Inventor
Gerald W. Hallworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of CA1187754A publication Critical patent/CA1187754A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/002Details of inhalators; Constructional features thereof with air flow regulating means

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A B S T R A C T

An inhalation device for administering medicaments in an aerosol container to a patient. The device has a housing in which an aerosol container can be located.
The aerosol container normally protrudes through an open end of the housing. An outlet mouthpiece leads from the interior of the housing. A passage is provided between the housing and the outlet through which air can flow when a patient inhales through the outlet, A valve is located in the passage. The valve is biassed so as normally to be in the open condition but will close automatically when the rate of flow of air inhaled by the patient exceeds a pre-determined amount.
The valve is conveniently n hinged flap which is spring-loaded towards the open position.

Description

75~

A B S T R A C T

An inhalation device Eor administering medicaments in an aerosol container -to a pat:ient. The device has a housing in which an aerosol container can be located.
The aerosol container normally protrudes th~ough an open end of the housing. An outle-t mouthpiece leads from the interio.r of the housing. A passage is provided between the housi.ng and the outlet through which air can flow when a patient inhales through the outlet.
A valve is located in the passage. The valve is biassed so as normally to ~e in the open condition but will close automatically when the rate of flow of air inhaled by the patient exceeds a pre-determined amount.
The valve is conveniently a hinged flap which is spring-loaded towards the open position.
BACKGROUND OF T~E INVENTION
It is well known to trea-t patients with medicament contained in an aerosol, for example, in bronchodilator therapy. It is known to use for such therapy medicaments which are con-tained in an aerosol and are administered to a patient by means of an inhalation device comprising a tubular housing or sleeve in which an aerosol container is located and a mouthpiece leading out of the tubular housing. In use, the aerosol container is placed in ~.' ~

7~

the tubular housing which .is then held by -the patient in a rnore or less upright condition and the mouthpiece of the inhalation device is placed in the mouth of tlle patient. The pa-tient inhales while operating the aerosol container to dispense medicament from the container through the mouthpiece into the patient.
It has been found in practice that proper co-ordination between -the act of inhaling and the act of operating the aerosol container to dispense the medicament is very difficult for some patients. Attempts have been made to solve this prohlem by providing such a device with a means for producing an audible signal when the aerosol container should be operated to dispense the medicament, i.e. when there is a proper rate of inhaled air flow. These known devices do not provide a really satisfactory solution to this problem. They can, for example, be extremely noisy when used in public with consequent e~.barrassment to a patient already under some stress.
An object of -the present invention is to overcome this disadvantage.
We have a:Lso discovered that it is often desirable to increase the resistance to inhaled air flow during the use o:E such a device hy a patien-t. A further object of -the presen-t invention is therefore to provide s~

such an inhalati.on device with which the resistance to inhaled air flow will au-toma-tically be increased while a pa-tien-t inhales through the device.
BR I 1~__5 UMD~RY OF T HE I N~7ENT I ON
The present in-vention provides an inhalation device for medicament in an aerosol container which device comprises a housing in which an aerosol container can be located, and an outle-t leading from the housing and communicating with the in-terior of the housing, wherein a passage is provided between the housing and the ou-tlet through which air can flow when a patient inhales through the outlet, a valve being located in the passage and arranged so as normally to be in the open position but being also arranged to close automa-tically when the rate of flow of air inhaled by the patient exceeds a pre-de-termined amount.
The valve is preferably a hinged flap which is movable ~ro~ a normal or inoperative position when the valve is open to a closed position in which it partially closes an a~er-ture through which air can flow from the housing to the mouthpiece. In another embodiment, the valve completely closes the aper-ture and an inlet for air is provided to permit air to enter the housing on '7'75~

the mouthpiece side o:F the closed valve. In yet another embodilrent, a slidable spring-loaded collar is usecl in the valve ins-tead of the flap member, the coLlar being biassed by the s~ring towards the inopera-tive posi-tion.
BRIEF DESCRII'TIOM OF THL` ACCOMPANYING
DRAhIN~S
Figure 1 is a sec-tional view of an inhalation device according to the invention, :LO Eligure 2 is a top view, Figure 3 is a front view, - E'igure ~ is a scrap sec-tional view of a modifica-tion, Figures 5 and 6 are sectional views illustrating ano-ther modification, and ~ igure 7 schema-tically illustrates a mouthpiece extension of the device.
DESCRIPTION OF SOME EMBODIMENTS
.
In the emhodimellt of the invention illus-trated in E`igures 1 to :3, all inhalat:iOn device primarily, but not 7~

exclusively, intended for use in pulmonary therapy with antl-inflamma-tory steroids and other agents is moulded from plastics material and comprises a -tubular housing or sleeve 1 in which an aerosol con-tainer ~ (shown only in Figure 1) is loca-ted. The drawings illustrate the inhalation clevice when it is in i-ts normal position of use ancl the device wil] be described as in this position.
The housing 1 has an open top through which the aerosol container 2 can protrude. The aerosol container 2 is placed in the housing 1 in the inverted condition, that is to say wi-th its outlet 3 at the bottom. The outlet is supported by a support pillar 4 which passes through a partition 5 which partly c]oses the lower end of the tubular housing 1. An aperture 6 communicates with a -15 passage 7 -through which the contents of the aerosol container can pass to an atomising nozzle 16 and thus to a mouthpiece 8 projecting laterally outwards from the tubular housing.
It will be seen from -the drawings that the partition 5 does not completely close the lower end of the tubular housing 1, a space 9 being provided -through which air inhaled by the patient through the mouthpiece can pass.
~hen a patien-t inhales, air enters -the housing 1 in the directions indicated by the arrows. The aerosol container
2 is held spaced Erom the lnner wall of the housing 1 by interrlal ribs 10 so that air can flow be-tween the outside 73L~/'7~

of the aerosol container and the inside of the housing through the space 9 and an opening 11 into the mouthpiece 8.
:[n the arrangement of -the present invention, a flap valve is provided to control par-t of the flow of inhaled air. For this purpose a valve surround or seat 12 (Figure 3) extends downwards from the par-tition 5 and has an opening 13 which can be closed by a flap 14 hinged to the par-tition at 15. The flap valve and the surround are moulded from plastics material in such a way that the hinged connec-tion between them has a spring action. The parts are moulded toge-ther to form a so-called "living hinge". The spring action of the hinge is arranged so tha-t the valve is normally biassed to an open position as clearly indicated par-ticularly in Figure 1. When there is a pre-determined rate of air flow through the housing 1, determined by the loading of the spring action at the hinge 15 and the size, shape and opened position of the flap and the profile of the housing around the flap, the valve will close automatically. When the flap valve .l4 closes, -the patien-t can sense -the action of the flap valve closing against -the support pillar 4 which acts as a stop givillcJ a dis-tinct souncl and feel through the lips.
Simultaneously, the patient can also sense the sudden :increase in air resi.stance. The sound is discreet and 7~

woul.cl not embarrass a patient using the device in public.
rhe detection of -the flap closing indicates -to the patient that -the aerosol container should be depressed immedi.ately to eject aerosol from the container so that it can pass in-to the mouthpiece.
If desired, instead of cons-tructing the flap valve and i-ts part:Ltion as a moulding with a living hinge, a weak spring could be used to bias -the flap to the open position. Such a spring could either be incorporated in the hinge i-tself, or coulcl be separately mounted to bear on the flap.
~ hen the flap valve 14 is closed a lesser quantity of air can sti.ll be ins2ired through a valve opening 11 in the surround 12 around the flap valve 14.
The air resistance of the device when the flap is open can be very low, for e~ample about 1-2 cm water at 60 litres/mi.n. The resistance when the flap is closed can, if desired, be pre-set to a considerably hi.gher value as desired by suitably selecting the size, shape and opened posltion of the flap and the profile of -the housing around the flap. It will be seen from Figure 3 that the flap valve 1.~ in its closed position does no-t completely close the opening through the valve surround ]2. It has beell sugc~es-ted that resistance to air flow when tlle valve i.s in its closed position should ~ ~77~
9 _ be rel.atively high, ior example 30-50 cm water at 60 li-tres/min -to encouracJe -the pa-tient to take a long deep brea-th and thus to obtai.n greater deposition oE the medicament in the aerosol illtO -the lungs. Alternatively, if desired, the resistance can be kept low after the flap valve cl.oses by use of an au~iliary air hole through the partit.ion 5 of the :Elap valve, or by arranging a suitable air qap round the flap in the closed position.
An alternative air inlet 17 (Figure 4) may be provided near the valve 1~ to give a straight air pathway from the inle-t pas-t the atomising nozzle to the mouthpiece.
In -that event, the par-tition 5 occupies the whole area of the interior of the housing and completely closes the lower end of -the housing 1 as shown in Figure 4. If desired, a plurality of inlets 17 may be provided. The inlet or inle-ts is/are provided with a dust cove.r (not shown)~ The device can also be modified to provide a spring of adjustable s-treng-th to control the opening o~
the flap valve 14. An indicator of -the loading of the spriny could be provided so as to be visible outside the device. This could give an adjustable indication of the point at which -the aerosol should be fired. Alternatively, it could be so calibrated to provide an inspirational Elow gauge for monltoring the condition of a patient.
Figures 5 and 6 iLlustrate a modification in which 7'7~

-the ~lap vaLve 14 is replacecl by a slidable collar 19 which is movable to and from a Eixecd valve seat 20 surrounding a tubular member 24 con-taining the opening 11.
A coil sprincJ 21 urges the collar 19 -to -the inopera-tive or open posi-tion shown in Figure 5 and when a patient inhales, -the collar is drawn against the biassing action oE the sprincJ 21 towards the closed position illustrated in Figure 5 in which it partially closes the space between the valve seat 20 and the tubular member 24. The air flow is indicated by arrows 22.
If desired, the mouthpiece 8 may be longer relative to the srze of the housing 1 than is indicated in the drawings Figures 1 to 5 and of adequate length and diameter in order -to promote increased drying and deceleration of the spray droplets from -the aerosol without excessive impingement in the mouthpiece before these impinge on the oropharynx and deeper large airways. This would reduce deposition of medicament in the oropharynx and other large airways. Figure 6 illustrates an extension member 23 ~hich is removable from the mouthpiece 8.

Claims (9)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
1. An inhalation device for medicament in an aerosol container, said device comprising a housing in which an aerosol container can be located and an outlet leading from the housing and communicating with the interior of the housing, so that air can flow from the housing to the outlet when a patient inhales through the outlet wherein a valve is arranged between the housing and the outlet and is normally in the open condition but being also arranged to close automatically when the rate of flow of air inhaled by the patient exceeds a pre-deter-mined amount.

2. A device as claimed in claim 1, wherein the housing is a tubular housing in which an aerosol container can be received, said housing being open at one end; the outlet extends laterally from the tubular housing near the other end of the housing; a partition is provided in the housing to provide on one side a portion in which an aerosol container can be located and a portion on the other side leading to the outlet and has an aperture through which the contents of the aerosol container can pass to the outlet; a valve surround extends from the partition on said other side and has a valve opening therein; a hinged flap is movable between an open position in which the said valve opening is fully open and a closed position;
Claim 2 continued and means for biassing the flap valve to its open position.
3. A device as claimed in claim 2, wherein the partition does not completely close the interior of the housing; and the valve flap is so arranged that when it is in the closed position, the valve opening is not completely closed whereby a lesser quantity of air can still be inspired through the outlet.
4. A device as claimed in claim 2, wherein the partition occupies the whole area of the interior of the tubular housing and at least one air inlet is provided through the housing on the outlet side of the partition, the flap valve being arranged substantially but not completely to close the opening in the valve surround.

5. A device as claimed in claim 1, wherein the housing is a tubular housing in which an aerosol container can be received, the said housing being open at one end, the outlet extends laterally from the tubular housing near the other of the housing; a partition is provided in-side the housing and has an aperture therein; a tubular member is positioned on the outlet side of the partition, the said member communicating with the outlet and being
Claim 5 continued arranged so that the contents of the aerosol can enter therein before passing to the outlet; a valve seat surrounding and spaced from the tubular member so that air can flow between them; a valve collar movable between an open position in which it is spaced from the valve seat and a closed position in which it partly closes the space between the tubular member and the valve seat;
and means for biassing the valve collar to its open position.
6. A device as claimed in any of claims 2, 3 or 4 wherein the tubular housing has internal ribs arranged to space the aerosol container from the interior of the housing.
7. A device as claimed in claim 5 wherein the tubular housing has internal ribs arranged to space the aerosol container from the interior of the housing.
8. A device as claimed in claims 2, 3 or 4 wherein the outlet is a mouthpiece having an extension member removably fitted thereon.
9. A device as claimed in claim 5 wherein the outlet is a mouthpiece having an extension member removably fitted thereon.
CA000409304A 1981-08-13 1982-08-12 Medical inhalation devices Expired CA1187754A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8124754 1981-08-13
GB8124754 1981-08-13

Publications (1)

Publication Number Publication Date
CA1187754A true CA1187754A (en) 1985-05-28

Family

ID=10523919

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000409304A Expired CA1187754A (en) 1981-08-13 1982-08-12 Medical inhalation devices

Country Status (19)

Country Link
JP (1) JPS5841569A (en)
AT (1) AT383742B (en)
AU (1) AU557902B2 (en)
BE (1) BE894101A (en)
CA (1) CA1187754A (en)
CH (1) CH660128A5 (en)
DE (1) DE3229702A1 (en)
DK (1) DK363082A (en)
ES (1) ES514991A0 (en)
FI (1) FI77576C (en)
FR (1) FR2511250B1 (en)
IE (1) IE53145B1 (en)
IL (1) IL67817A0 (en)
IT (1) IT1148407B (en)
NL (1) NL8203170A (en)
NO (1) NO153283C (en)
NZ (1) NZ201567A (en)
SE (1) SE437220B (en)
ZA (1) ZA825833B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01106095A (en) * 1987-10-20 1989-04-24 Sanyo Electric Co Ltd Voice recognition system
DE3911985C1 (en) * 1989-04-12 1990-11-08 Boehringer Ingelheim Kg, 6507 Ingelheim, De Inhaler attachment for medical aerosol - has tubular housing with axially adjustable valve needle
US6615826B1 (en) 1999-02-26 2003-09-09 3M Innovative Properties Company Slow spray metered dose inhaler
ATE311917T1 (en) 2002-02-14 2005-12-15 Atmed Ag INHALATION ASSISTANCE DEVICE

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361306A (en) * 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3456646A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
GB1270272A (en) * 1969-04-03 1972-04-12 Riker Laboratories Inc Improved dispensing devices for use with or including aerosol dispensing containers
US3732864A (en) * 1971-06-07 1973-05-15 Schering Corp Inhalation coordinated aerosol dispensing device
GB1413285A (en) * 1971-11-25 1975-11-12 Bespak Industries Ltd Aerosol devices
IL58720A (en) * 1979-01-11 1984-02-29 Scherico Ltd Inhalation device
EP0013534A1 (en) * 1979-01-11 1980-07-23 Technobiotic Ltd. Inhalation device
DE3040641A1 (en) * 1980-10-29 1982-05-27 C.H. Boehringer Sohn, 6507 Ingelheim Mouthpiece for aerosol inhalation - with flat and slider for actuation by inspiration

Also Published As

Publication number Publication date
ZA825833B (en) 1984-04-25
IE821955L (en) 1983-02-13
SE437220B (en) 1985-02-18
ES8400245A1 (en) 1983-10-16
FI822808A0 (en) 1982-08-12
FR2511250B1 (en) 1986-02-28
AU8711982A (en) 1983-02-17
FI77576C (en) 1989-04-10
SE8204675L (en) 1983-02-14
FI822808L (en) 1983-02-14
NO830294L (en) 1984-07-30
IT1148407B (en) 1986-12-03
NL8203170A (en) 1983-03-01
ES514991A0 (en) 1983-10-16
IT8248988A0 (en) 1982-08-13
SE8204675D0 (en) 1982-08-12
DK363082A (en) 1983-02-14
BE894101A (en) 1983-02-14
FI77576B (en) 1988-12-30
JPS5841569A (en) 1983-03-10
NO153283C (en) 1986-02-19
NZ201567A (en) 1985-08-30
ATA33783A (en) 1987-01-15
FR2511250A1 (en) 1983-02-18
CH660128A5 (en) 1987-03-31
AT383742B (en) 1987-08-10
IL67817A0 (en) 1983-06-15
AU557902B2 (en) 1987-01-15
NO153283B (en) 1985-11-11
IE53145B1 (en) 1988-07-20
DE3229702A1 (en) 1983-03-03

Similar Documents

Publication Publication Date Title
GB2104393A (en) Medical Inhalation Devices
US4570630A (en) Medicament inhalation device
US4005711A (en) Inhalation device
US4227522A (en) Inhalation device
US5727542A (en) General purpose aerosol inhalation apparatus
CA1054479A (en) Inhalation device
US4198969A (en) Suction-operated nebulizer
US6062214A (en) Inhaler for medicament
CA2820985C (en) Nebulizer apparatus and method
FI69962B (en) INHALERINGSANORDNING
US3630196A (en) Manual positive pressure breathing device
US3964483A (en) Inhalation device
CA2610334C (en) Nebulizer mask for delivery of aerosolized and nebulized medications
US20050279349A1 (en) Method and device for delivering aerosolized medicaments
JPH11506642A (en) Nebulizer respiratory circulator
US20020151813A1 (en) Flow based incentiv spirometer
IE45837B1 (en) Device for use with pressurised aerosol type medicinal inhalation devices
EP1357880A2 (en) Apparatus for administering intermittent percussive ventilation and unitary breathing head assembly for use therein
JP2002502673A (en) Prescribed dose suction pump
CA2614628A1 (en) Inhalation device with a bottom surface formed as a foot
JP2001514054A (en) Breath-actuated nebulizer with valve assembly having relief piston
NO792917L (en) Inhalation-DEVICE.
GB2279879A (en) Medicament inhalers
JPS6017543B2 (en) drug inhalation device
WO1986001731A1 (en) All purpose nebulizer

Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry