CA1181008A - METHOD OF PRODUCING .gamma.-GLOBULIN FOR INTRAVENOUS INJECTION AND THERAPEUTIC AGENT PRODUCED THEREBY - Google Patents

METHOD OF PRODUCING .gamma.-GLOBULIN FOR INTRAVENOUS INJECTION AND THERAPEUTIC AGENT PRODUCED THEREBY

Info

Publication number
CA1181008A
CA1181008A CA000404158A CA404158A CA1181008A CA 1181008 A CA1181008 A CA 1181008A CA 000404158 A CA000404158 A CA 000404158A CA 404158 A CA404158 A CA 404158A CA 1181008 A CA1181008 A CA 1181008A
Authority
CA
Canada
Prior art keywords
globulin
enzyme
gamma
pepsin
uropepsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000404158A
Other languages
English (en)
French (fr)
Inventor
Haruo Ohnishi
Hiroshi Kosuzume
Yasuo Suzuki
Ei Mochida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Application granted granted Critical
Publication of CA1181008A publication Critical patent/CA1181008A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CA000404158A 1981-05-29 1982-05-31 METHOD OF PRODUCING .gamma.-GLOBULIN FOR INTRAVENOUS INJECTION AND THERAPEUTIC AGENT PRODUCED THEREBY Expired CA1181008A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP56082903A JPS57206608A (en) 1981-05-29 1981-05-29 Production of gamma-globulin for intravenous injection
JP56-82903 1981-05-29
CH4039/82A CH657376A5 (en) 1981-05-29 1982-07-02 Process for the preparation of gamma-globulin for intravenous injection
AU85637/82A AU551759B2 (en) 1981-05-29 1982-07-06 Alpha-globulin preparation

Publications (1)

Publication Number Publication Date
CA1181008A true CA1181008A (en) 1985-01-15

Family

ID=36764503

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000404158A Expired CA1181008A (en) 1981-05-29 1982-05-31 METHOD OF PRODUCING .gamma.-GLOBULIN FOR INTRAVENOUS INJECTION AND THERAPEUTIC AGENT PRODUCED THEREBY

Country Status (9)

Country Link
US (1) US4436724A (enExample)
JP (1) JPS57206608A (enExample)
AU (1) AU551759B2 (enExample)
BE (1) BE893798A (enExample)
CA (1) CA1181008A (enExample)
CH (1) CH657376A5 (enExample)
DE (1) DE3220309A1 (enExample)
FR (1) FR2506616A1 (enExample)
GB (1) GB2104080B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT383738B (de) * 1983-03-16 1987-08-10 Immuno Ag Verfahren zur verwendung einer immunglobulin-g enthaltenden fraktion
AT383739B (de) * 1983-03-16 1987-08-10 Immuno Ag Verfahren zur inaktivierung von unvertraeglichkeitsreaktionen verursachenden substanzen in immunglobulinhaeltigen blutfraktionen
AT383737B (de) * 1983-03-16 1987-08-10 Immuno Ag Verfahren zur verwendung einer immunoglobulin-g enthaltenden fraktion
GB8406560D0 (en) * 1984-03-13 1984-04-18 Central Lab Of The Blood Donor Organic compounds
DE3411735A1 (de) * 1984-03-30 1985-10-03 Karl Pfisterer Elektrotechnische Spezialartikel Gmbh & Co Kg, 7000 Stuttgart Ueberspannungsableiter
JPH07121875B2 (ja) * 1985-10-08 1995-12-25 武田薬品工業株式会社 免疫グロブリンフラクシヨンの製造法
AT390560B (de) * 1986-05-30 1990-05-25 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern
US5328834A (en) * 1989-09-08 1994-07-12 Unisyn Technologies, Inc. Method for preparing immunoglobulin fragments
US5340737A (en) * 1993-06-10 1994-08-23 Marcel Siegler Process of preparing pepsin for bating hides
US6348346B1 (en) 1994-05-27 2002-02-19 University Of Kentucky Research Foundation Method of inhibiting binding activity of immunoglobulins
FI952196A0 (fi) * 1995-05-08 1995-05-08 Suomen Punainen Risti Veripalv Framstaellning av immunoglobulin
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1148037B (de) * 1961-10-11 1963-05-02 Behringwerke Ag Verfahren zur Herstellung eines desaggregierten, das Komplementsystem nicht beeinflussenden Gammaglobulins
CH392780A (de) * 1961-12-07 1965-05-31 Schweiz Rotes Kreuz Verfahren zur Herstellung von intravenös anwendbaren Antikörperpräparaten humanen Ursprungs
US3553317A (en) 1969-06-02 1971-01-05 Joseph B Michaelson Ig-a antibody from lacteal fluids
CA1064396A (en) 1975-02-18 1979-10-16 Myer L. Coval Fractional precipitation of gamma globulin with polyethylene glycol
DE2835843A1 (de) 1978-08-16 1980-02-28 Blutspendedienst Dt Rote Kreuz Verfahren zur herstellung einer fuer die intravenoese anwendung geeigneten gammaglobulinloesung
JPS5615215A (en) * 1979-07-14 1981-02-14 Nippon Sekijiyuujishiya Preparation of human immunoglobulin for intravenous injection with immobilized pepsin gel

Also Published As

Publication number Publication date
FR2506616B1 (enExample) 1984-08-10
CH657376A5 (en) 1986-08-29
JPS6136811B2 (enExample) 1986-08-20
DE3220309A1 (de) 1982-12-16
GB2104080A (en) 1983-03-02
JPS57206608A (en) 1982-12-18
AU8563782A (en) 1984-01-12
GB2104080B (en) 1984-08-01
FR2506616A1 (fr) 1982-12-03
BE893798A (fr) 1982-11-03
AU551759B2 (en) 1986-05-08
US4436724A (en) 1984-03-13

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Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry