CA1180006A - Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use - Google Patents

Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use

Info

Publication number
CA1180006A
CA1180006A CA000319376A CA319376A CA1180006A CA 1180006 A CA1180006 A CA 1180006A CA 000319376 A CA000319376 A CA 000319376A CA 319376 A CA319376 A CA 319376A CA 1180006 A CA1180006 A CA 1180006A
Authority
CA
Canada
Prior art keywords
amino acid
peptide
acid residues
peptide bond
joined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000319376A
Other languages
English (en)
French (fr)
Inventor
John A. Yankeelov, Jr.
Kam-Fook Fok
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp
Original Assignee
Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp filed Critical Research Corp
Application granted granted Critical
Publication of CA1180006A publication Critical patent/CA1180006A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/16—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA000319376A 1978-01-11 1979-01-10 Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use Expired CA1180006A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86862678A 1978-01-11 1978-01-11
US868,626 1978-01-11
US96210078A 1978-11-20 1978-11-20
US962,100 1992-10-16

Publications (1)

Publication Number Publication Date
CA1180006A true CA1180006A (en) 1984-12-27

Family

ID=27128063

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000319376A Expired CA1180006A (en) 1978-01-11 1979-01-10 Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use

Country Status (5)

Country Link
CA (1) CA1180006A (enrdf_load_stackoverflow)
CH (1) CH641441A5 (enrdf_load_stackoverflow)
DE (1) DE2900926A1 (enrdf_load_stackoverflow)
FR (1) FR2414498A1 (enrdf_load_stackoverflow)
GB (1) GB2013210B (enrdf_load_stackoverflow)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1463865A (fr) * 1964-07-27 1966-07-22 Ceskoslovenska Akademie Ved Procédé pour la préparation des dérivés cycliques de peptides ainsi que les produits conformes à ceux obtenus par le présent procédé ou procédé similaire

Also Published As

Publication number Publication date
FR2414498B1 (enrdf_load_stackoverflow) 1982-08-27
DE2900926A1 (de) 1979-07-19
FR2414498A1 (fr) 1979-08-10
DE2900926C2 (enrdf_load_stackoverflow) 1991-01-17
GB2013210A (en) 1979-08-08
CH641441A5 (de) 1984-02-29
GB2013210B (en) 1982-04-28

Similar Documents

Publication Publication Date Title
US4693993A (en) Bradykinin antagonist peptides
AU746461B2 (en) Peptide parathyroid hormone analogs
CA1311583C (en) Peptide derivatives and their application, in particular in therapy
KR100360639B1 (ko) N-치환글리신함유브라디키닌길항제펩티드
JPH10506608A (ja) 白血球接着のインヒビター
US4801613A (en) Bradykinin antagonist peptides
NO310294B1 (no) Nye inhibitorer for trombin
BG65065B1 (bg) Пептидни антиангиогенни лекарствени средства
US5834431A (en) Des-Arg9 -BK antagonists
AU703256B2 (en) Bradykinin analogs as selective thrombin inhibitors
US4631270A (en) Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use
JPH02500517A (ja) ペプチド化合物
EP0037516B1 (en) N-omega substituted derivatives of 1-desamino-vasopressin analogs
NO891006L (no) Terapeutisk aktivt polypeptid og fremgangsmaate for dets fremstilling.
JP5433586B2 (ja) ペプチド修飾の方法
CA2610496A1 (en) Synthetic peptide inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
EP0570428B1 (en) FACTOR IIa INHIBITORS
JP2001514659A (ja) ドラスタチン−１５誘導体とタキサンとの併用
IE910469A1 (en) Stabilized sulfonate, sulfate, phosphonate and phosphate¹derivatives of hirudin
CA1180006A (en) Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use
US4829051A (en) N-substituted derivatives of 1-desaminovasopressin
DE69420574T2 (de) Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen
EP0332688A1 (en) Bradykinin antagonist peptides
JP3465923B2 (ja) 新規ペプチド、それを製造する方法及び用途
JP3465921B2 (ja) 新規ペプチド、それを製造する方法及び用途

Legal Events

Date Code Title Description
MKEX Expiry