CA1179603A - Indacrinone having enhanced uricosuric properties - Google Patents

Indacrinone having enhanced uricosuric properties

Info

Publication number
CA1179603A
CA1179603A CA000406976A CA406976A CA1179603A CA 1179603 A CA1179603 A CA 1179603A CA 000406976 A CA000406976 A CA 000406976A CA 406976 A CA406976 A CA 406976A CA 1179603 A CA1179603 A CA 1179603A
Authority
CA
Canada
Prior art keywords
enantiomer
indacrinone
weight
proline
total
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000406976A
Other languages
English (en)
French (fr)
Inventor
Edward H. Blaine
Jonathan A. Tobert
John F. Nancarrow
Ralph F. Hirschmann
Edward J. Cragoe, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA1179603A publication Critical patent/CA1179603A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA000406976A 1981-07-13 1982-07-09 Indacrinone having enhanced uricosuric properties Expired CA1179603A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28236081A 1981-07-13 1981-07-13
US282,360 1981-07-13

Publications (1)

Publication Number Publication Date
CA1179603A true CA1179603A (en) 1984-12-18

Family

ID=23081158

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000406976A Expired CA1179603A (en) 1981-07-13 1982-07-09 Indacrinone having enhanced uricosuric properties

Country Status (9)

Country Link
EP (1) EP0069846A1 (enExample)
JP (2) JPS5810516A (enExample)
AU (1) AU548904B2 (enExample)
CA (1) CA1179603A (enExample)
DK (1) DK223582A (enExample)
GR (1) GR78032B (enExample)
NZ (1) NZ200641A (enExample)
PT (1) PT74955B (enExample)
ZA (1) ZA823538B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1531221A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
US4693996A (en) * 1985-12-23 1987-09-15 Warner-Lambert Company Method of treating heart failure and medicaments therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7412823A (nl) * 1973-10-11 1975-04-15 Merck & Co Inc Werkwijze voor het bereiden van diuretisch ame preparaten en de door toepassing an verkregen voorwerpen.
PL98342B1 (pl) * 1974-07-30 1978-04-29 Sposob wytwarzania kwasu 1-keto-2-arylo-/lub tienylo/-2-podstawionego-indanyloksy-/lub tio/-5-alkanokarboksylowego
US4087542A (en) * 1975-07-09 1978-05-02 Merck & Co., Inc. 2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids

Also Published As

Publication number Publication date
AU548904B2 (en) 1986-01-09
PT74955B (en) 1985-05-16
PT74955A (en) 1982-06-01
DK223582A (da) 1983-01-14
JPS5946220A (ja) 1984-03-15
JPS5810516A (ja) 1983-01-21
ZA823538B (en) 1983-12-28
GR78032B (enExample) 1984-09-26
NZ200641A (en) 1985-12-13
AU8385482A (en) 1983-01-20
EP0069846A1 (en) 1983-01-19

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Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry