CA1168967A - Diagnostic device for fecal occult blood - Google Patents
Diagnostic device for fecal occult bloodInfo
- Publication number
- CA1168967A CA1168967A CA000386468A CA386468A CA1168967A CA 1168967 A CA1168967 A CA 1168967A CA 000386468 A CA000386468 A CA 000386468A CA 386468 A CA386468 A CA 386468A CA 1168967 A CA1168967 A CA 1168967A
- Authority
- CA
- Canada
- Prior art keywords
- test
- matrix
- chelating agent
- edta
- guanidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008280 blood Substances 0.000 title claims abstract description 33
- 210000004369 blood Anatomy 0.000 title claims abstract description 33
- 230000002550 fecal effect Effects 0.000 title claims abstract description 14
- 238000012360 testing method Methods 0.000 claims abstract description 64
- 102000003992 Peroxidases Human genes 0.000 claims abstract description 57
- 239000011159 matrix material Substances 0.000 claims abstract description 36
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229960000789 guanidine hydrochloride Drugs 0.000 claims abstract description 24
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims abstract description 24
- 241000147041 Guaiacum officinale Species 0.000 claims abstract description 23
- 229940091561 guaiac Drugs 0.000 claims abstract description 23
- 239000002738 chelating agent Substances 0.000 claims abstract description 18
- 150000001875 compounds Chemical class 0.000 claims abstract description 16
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 12
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000011575 calcium Substances 0.000 claims abstract description 11
- 239000001257 hydrogen Substances 0.000 claims abstract description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 10
- 108700020962 Peroxidase Proteins 0.000 claims abstract description 6
- 238000002405 diagnostic procedure Methods 0.000 claims abstract description 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000011777 magnesium Substances 0.000 claims abstract description 4
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 3
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 24
- 230000000694 effects Effects 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 21
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 12
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 12
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 12
- 229960004198 guanidine Drugs 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 11
- 229910001424 calcium ion Inorganic materials 0.000 claims description 9
- 229940088598 enzyme Drugs 0.000 claims description 9
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 9
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical class OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 9
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- 230000002452 interceptive effect Effects 0.000 claims description 8
- 239000004202 carbamide Chemical class 0.000 claims description 7
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims description 7
- 230000006872 improvement Effects 0.000 claims description 6
- 230000002255 enzymatic effect Effects 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 claims 2
- 238000009740 moulding (composite fabrication) Methods 0.000 claims 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 1
- 229940072417 peroxidase Drugs 0.000 description 35
- 108040007629 peroxidase activity proteins Proteins 0.000 description 35
- 102000001554 Hemoglobins Human genes 0.000 description 23
- 108010054147 Hemoglobins Proteins 0.000 description 22
- 239000000243 solution Substances 0.000 description 15
- 235000011293 Brassica napus Nutrition 0.000 description 14
- 240000008100 Brassica rapa Species 0.000 description 14
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 14
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 12
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000011161 development Methods 0.000 description 5
- 239000006166 lysate Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 235000013311 vegetables Nutrition 0.000 description 5
- 240000003291 Armoracia rusticana Species 0.000 description 4
- 235000011330 Armoracia rusticana Nutrition 0.000 description 4
- 150000002978 peroxides Chemical class 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 238000009534 blood test Methods 0.000 description 3
- 229950007919 egtazic acid Drugs 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 238000009533 lab test Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Chemical class OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 244000291564 Allium cepa Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000020805 dietary restrictions Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 108010001073 oxyhemoglobin oxidase Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/725—Haemoglobin using peroxidative activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/195,220 US4333734A (en) | 1980-01-18 | 1980-10-08 | Diagnostic device for fecal occult blood and method of use |
| US195,220 | 1980-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1168967A true CA1168967A (en) | 1984-06-12 |
Family
ID=22720504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000386468A Expired CA1168967A (en) | 1980-10-08 | 1981-09-23 | Diagnostic device for fecal occult blood |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4333734A (esLanguage) |
| EP (1) | EP0050733B1 (esLanguage) |
| JP (1) | JPS57141300A (esLanguage) |
| AU (1) | AU558827B2 (esLanguage) |
| CA (1) | CA1168967A (esLanguage) |
| DE (1) | DE3174811D1 (esLanguage) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI61965C (fi) | 1980-01-17 | 1982-10-11 | Suovaniemi Finnpipette | Foerfarande foer detektering av hemoglobin i avfoering |
| US4956300A (en) | 1982-01-05 | 1990-09-11 | Helena Laboratories Corporation | Aid for determining the presence of occult blood, method of making the aid, and method of using the aid |
| US4486536A (en) * | 1982-05-28 | 1984-12-04 | Smithkline Diagnostics, Inc. | Specimen slide for occult blood testing |
| US4493892A (en) * | 1982-12-20 | 1985-01-15 | Memorial Hospital For Cancer & Allied Diseases | Solvent system for peroxidase inhibitor reagent for fecal occult blood determinations |
| US4578359A (en) * | 1983-05-03 | 1986-03-25 | Warner-Lambert Company | Occult-blood detection |
| US4578358A (en) * | 1983-05-03 | 1986-03-25 | Warner-Lambert Company | Collection of specimens and detection of occult blood therein |
| US5702913A (en) | 1983-12-21 | 1997-12-30 | Helena Laboratories Corporation | Chromgen-reagent test system |
| US5273888A (en) | 1984-01-16 | 1993-12-28 | Helena Laboratories Corporation | Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals |
| EP0355864A3 (en) * | 1984-03-15 | 1991-09-18 | Wako Pure Chemical Industries, Ltd. | Method of quantitatively measuring an oxidative substance by using triphenyl methane type leuco compounds as coloring matter |
| US4615982A (en) * | 1984-12-11 | 1986-10-07 | Lawrence Paul J | Fecal occult blood test |
| US4939097A (en) * | 1986-06-02 | 1990-07-03 | Litmus Concepts, Inc. | Fecal occult blood test methods |
| NO157437C (no) * | 1985-08-30 | 1988-03-16 | Scandinavian Analytical Produc | Proeveinnretning for bestemmelse av blod i faeces. |
| US4818702A (en) * | 1986-06-02 | 1989-04-04 | Litmus Concepts, Inc. | Fecal occult blood test reagent |
| US5081040A (en) | 1987-06-29 | 1992-01-14 | Helena Laboratories Corporation | Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes |
| CA1322326C (en) * | 1987-09-16 | 1993-09-21 | Josefina Tecson Baker | Test for fecal occult blood |
| US5310680A (en) * | 1987-09-16 | 1994-05-10 | Smithkline Diagnostics, Inc. | Test for fecal occult blood |
| US5053342A (en) * | 1987-12-24 | 1991-10-01 | Litmus Concepts, Inc. | Fecal occult blood test reagents |
| WO1990002339A1 (en) * | 1988-08-16 | 1990-03-08 | Cetus Corporation | Stable indicator solutions for detection of peroxidatic activity |
| US5182191A (en) * | 1988-10-14 | 1993-01-26 | Pacific Biotech, Inc. | Occult blood sampling device and assay |
| US5196167A (en) | 1989-04-04 | 1993-03-23 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5217874A (en) | 1989-04-04 | 1993-06-08 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| ES2118062T3 (es) * | 1989-12-15 | 1998-09-16 | Hoffmann La Roche | Composiciones reactivas, metodos y reactivos para la valoracion cuantitativa de magnesio o de calcio y magnesio. |
| JPH0736013B2 (ja) * | 1991-04-27 | 1995-04-19 | 一男 田畑 | 潜血検出用試薬 |
| US5447868A (en) | 1993-09-14 | 1995-09-05 | Propper Manufacturing Co. Inc. | Method, reagent and kit for the detection of fecal occult blood |
| US5670325A (en) * | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| EP1291657A3 (en) | 1996-01-30 | 2003-08-27 | Exact Sciences Corporation | Methods for detecting colon cancer from stool samples |
| US5741650A (en) * | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
| US6146828A (en) * | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
| US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
| US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
| US6020137A (en) * | 1996-08-14 | 2000-02-01 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US5928870A (en) * | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
| US6406857B1 (en) | 1997-06-16 | 2002-06-18 | Exact Sciences Corporation | Methods for stool sample preparation |
| US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
| US20020064792A1 (en) * | 1997-11-13 | 2002-05-30 | Lincoln Stephen E. | Database for storage and analysis of full-length sequences |
| USD445906S1 (en) | 1998-08-11 | 2001-07-31 | Diagnostica, Inc. | Test kit housing |
| US6436714B1 (en) | 1998-08-11 | 2002-08-20 | Diagnostica, Inc. | Self-contained system and method for testing for fecal occult blood |
| USD427320S (en) * | 1998-08-11 | 2000-06-27 | Diagnostica, Inc | Test kit housing |
| US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
| US6280947B1 (en) | 1999-08-11 | 2001-08-28 | Exact Sciences Corporation | Methods for detecting nucleotide insertion or deletion using primer extension |
| US6551777B1 (en) | 1999-02-25 | 2003-04-22 | Exact Sciences Corporation | Methods for preserving DNA integrity |
| JP4794052B2 (ja) | 1999-04-09 | 2011-10-12 | ジェンザイム・コーポレーション | 癌の指標である核酸を検出するための方法 |
| US6849403B1 (en) | 1999-09-08 | 2005-02-01 | Exact Sciences Corporation | Apparatus and method for drug screening |
| US6586177B1 (en) * | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
| US6919174B1 (en) | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
| WO2001042781A2 (en) * | 1999-12-07 | 2001-06-14 | Exact Sciences Corporation | Supracolonic aerodigestive neoplasm detection |
| US7776524B2 (en) * | 2002-02-15 | 2010-08-17 | Genzyme Corporation | Methods for analysis of molecular events |
| US7189356B1 (en) | 2002-05-03 | 2007-03-13 | Diagnostica, Inc. | Occult blood testing apparatus with features for enhancing ease of use |
| SG173922A1 (en) * | 2002-11-27 | 2011-09-29 | Incyte Corp | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
| US20040259101A1 (en) * | 2003-06-20 | 2004-12-23 | Shuber Anthony P. | Methods for disease screening |
| US20080241827A1 (en) * | 2004-05-10 | 2008-10-02 | Exact Sciences Corporation | Methods For Detecting A Mutant Nucleic Acid |
| WO2005113769A1 (en) * | 2004-05-14 | 2005-12-01 | Exact Sciences Corporation | Method for stabilizing biological samples for nucleic acid analysis |
| US8679420B2 (en) * | 2004-07-22 | 2014-03-25 | Immunostics, Inc. | Fecal sampling device and method |
| US20080241940A1 (en) * | 2004-07-22 | 2008-10-02 | Lastella Vincent P | Fecal sampling device and method |
| EP2058661A1 (en) * | 2004-07-22 | 2009-05-13 | Immunostics, Inc. | Fecal occult blood testing device and method |
| US7427505B2 (en) * | 2004-07-22 | 2008-09-23 | Immunostics, Inc. | Fecal occult blood testing device and method |
| US7981607B2 (en) * | 2004-08-27 | 2011-07-19 | Esoterix Genetic Laboratories LLC | Method for detecting recombinant event |
| WO2006047787A2 (en) | 2004-10-27 | 2006-05-04 | Exact Sciences Corporation | Method for monitoring disease progression or recurrence |
| US9777314B2 (en) * | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
| WO2006110939A1 (en) * | 2005-04-22 | 2006-10-26 | Commonwealth Scientific And Industrial Research Organisation | Detection of endoparasites in herbivores |
| US8114587B2 (en) * | 2005-06-23 | 2012-02-14 | Ambergen, Inc. | Methods for the detection of colorectal cancer |
| US7592181B2 (en) * | 2006-09-25 | 2009-09-22 | Diagnostica, Inc. | Occult blood testing device |
| US8304596B2 (en) | 2008-04-11 | 2012-11-06 | Immunostics, Inc. | Fecal sampling device and method |
| GB201107466D0 (en) | 2011-05-05 | 2011-06-15 | Loktionov Alexandre | Device and method for non-invasive collection of colorectal mucocellular layer and disease detection |
| EP2680003A1 (en) | 2012-06-28 | 2014-01-01 | Fundació Institut d'Investigació Biomèdica de Bellvitge | Serum biomarker for diagnosing colorectal cancer |
| DE102012013888A1 (de) | 2012-07-09 | 2014-05-22 | Schebo Biotech Ag | Testkit (Kombi-Schnelltest) zum synchronen Nachweis von Biomarkern im Stuhl zur Erkennung pathologischer Veränderungen im Gastrointestinaltrakt, insbesondere im Darm |
| EP4669108A1 (de) * | 2023-02-23 | 2025-12-31 | THOR GmbH | Synergistische zusammensetzungen enthaltend guanidin |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2905594A (en) * | 1956-04-25 | 1959-09-22 | Herman J Morris | Means for detecting enzyme activity |
| US2990338A (en) * | 1959-11-24 | 1961-06-27 | Gibson Jacob John | Composition for determination of glucose in body fluids |
| AR204182A1 (es) * | 1973-12-20 | 1975-11-28 | Boehringer Mannheim Gmbh | Tira de ensayo para la comprobacion de substancias de actividad peroxidica en los liquidos del cuerpo |
| US3933594A (en) * | 1974-08-16 | 1976-01-20 | Polaroid Corporation | Method and device for determining the concentration of a substance in a fluid |
| CS175782B1 (esLanguage) * | 1974-10-16 | 1977-05-31 | ||
| US4175923A (en) * | 1978-06-26 | 1979-11-27 | Friend William G | Method and apparatus for occult blood testing in the home |
| DE2850603A1 (de) * | 1978-11-22 | 1980-06-19 | Merck Patent Gmbh | Haemolysierloesung und verfahren zur haemolyse von blut |
| JPS5592698A (en) * | 1978-12-31 | 1980-07-14 | Kyoto Daiichi Kagaku:Kk | Test strip for glucose determination |
| DE2910737C2 (de) * | 1979-03-19 | 1984-01-19 | Ewald 6701 Dannstadt-Schauernheim Blees | Verfahren zur Ausschaltung störender Begleitreaktionen bei enzymatischen Analysenverfahren |
| US4277250A (en) * | 1979-12-10 | 1981-07-07 | Baylor College Of Medicine | Methods for detecting and quantifying occult blood |
| AU543007B2 (en) * | 1980-04-15 | 1985-03-28 | Technicon Instruments Corportion | Agglutination immunoassay |
-
1980
- 1980-10-08 US US06/195,220 patent/US4333734A/en not_active Expired - Lifetime
-
1981
- 1981-09-18 EP EP81107396A patent/EP0050733B1/en not_active Expired
- 1981-09-18 DE DE8181107396T patent/DE3174811D1/de not_active Expired
- 1981-09-23 CA CA000386468A patent/CA1168967A/en not_active Expired
- 1981-09-24 AU AU75637/81A patent/AU558827B2/en not_active Ceased
- 1981-10-08 JP JP56159577A patent/JPS57141300A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57141300A (en) | 1982-09-01 |
| AU558827B2 (en) | 1987-02-12 |
| EP0050733B1 (en) | 1986-06-11 |
| AU7563781A (en) | 1982-04-22 |
| US4333734A (en) | 1982-06-08 |
| EP0050733A3 (en) | 1982-06-23 |
| JPH0247704B2 (esLanguage) | 1990-10-22 |
| EP0050733A2 (en) | 1982-05-05 |
| DE3174811D1 (en) | 1986-07-17 |
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| Date | Code | Title | Description |
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| MKEX | Expiry |