CA1166255A - 4,5-dihydro-6-(pyridinyl)-3(2h)-pyridazinones substituees en 2, preparation et utilisation comme agents cardiotoniques - Google Patents

4,5-dihydro-6-(pyridinyl)-3(2h)-pyridazinones substituees en 2, preparation et utilisation comme agents cardiotoniques

Info

Publication number
CA1166255A
CA1166255A CA000376356A CA376356A CA1166255A CA 1166255 A CA1166255 A CA 1166255A CA 000376356 A CA000376356 A CA 000376356A CA 376356 A CA376356 A CA 376356A CA 1166255 A CA1166255 A CA 1166255A
Authority
CA
Canada
Prior art keywords
pyridinyl
methyl
acid
process according
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000376356A
Other languages
English (en)
Inventor
George Y. Lesher
William B. Dickinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Application granted granted Critical
Publication of CA1166255A publication Critical patent/CA1166255A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA000376356A 1980-04-28 1981-04-27 4,5-dihydro-6-(pyridinyl)-3(2h)-pyridazinones substituees en 2, preparation et utilisation comme agents cardiotoniques Expired CA1166255A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14456480A 1980-04-28 1980-04-28
US144,564 1980-04-28

Publications (1)

Publication Number Publication Date
CA1166255A true CA1166255A (fr) 1984-04-24

Family

ID=22509146

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000376356A Expired CA1166255A (fr) 1980-04-28 1981-04-27 4,5-dihydro-6-(pyridinyl)-3(2h)-pyridazinones substituees en 2, preparation et utilisation comme agents cardiotoniques

Country Status (6)

Country Link
JP (1) JPS572284A (fr)
KR (1) KR830005202A (fr)
AU (1) AU6991781A (fr)
BE (1) BE888567A (fr)
CA (1) CA1166255A (fr)
ZA (1) ZA812698B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011123A1 (fr) * 1991-11-29 1993-06-10 Zenyaku Kogyo Kabushiki Kaisha Compose heterocyclique et cardiotonique contenant ce compose comme ingredient actif

Also Published As

Publication number Publication date
BE888567A (fr) 1981-10-27
AU6991781A (en) 1981-11-05
ZA812698B (en) 1982-04-28
JPS572284A (en) 1982-01-07
KR830005202A (ko) 1983-08-03

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Legal Events

Date Code Title Description
MKEX Expiry