CA1156650A - Heparin web and process - Google Patents
Heparin web and processInfo
- Publication number
- CA1156650A CA1156650A CA000376962A CA376962A CA1156650A CA 1156650 A CA1156650 A CA 1156650A CA 000376962 A CA000376962 A CA 000376962A CA 376962 A CA376962 A CA 376962A CA 1156650 A CA1156650 A CA 1156650A
- Authority
- CA
- Canada
- Prior art keywords
- heparin
- blood
- web
- salt
- heparin salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 70
- 238000000034 method Methods 0.000 title claims description 29
- 230000008569 process Effects 0.000 title claims description 15
- 229920000669 heparin Polymers 0.000 title description 44
- 229960002897 heparin Drugs 0.000 title description 36
- 239000008280 blood Substances 0.000 claims abstract description 47
- 210000004369 blood Anatomy 0.000 claims abstract description 46
- 229920001410 Microfiber Polymers 0.000 claims description 29
- 239000003658 microfiber Substances 0.000 claims description 29
- 239000012530 fluid Substances 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 15
- 150000001768 cations Chemical class 0.000 claims description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 10
- 239000012266 salt solution Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000011261 inert gas Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000000835 fiber Substances 0.000 abstract description 14
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 23
- 239000007789 gas Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 239000003146 anticoagulant agent Substances 0.000 description 6
- 229940127219 anticoagulant drug Drugs 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- -1 alkaline earth metal cation Chemical class 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 238000007664 blowing Methods 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 238000004868 gas analysis Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 108010074860 Factor Xa Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000014508 negative regulation of coagulation Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/10—Heparin; Derivatives thereof
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/54—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
- D04H1/56—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nonwoven Fabrics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15275180A | 1980-05-23 | 1980-05-23 | |
| US152,751 | 1980-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1156650A true CA1156650A (en) | 1983-11-08 |
Family
ID=22544279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000376962A Expired CA1156650A (en) | 1980-05-23 | 1981-05-06 | Heparin web and process |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0041771A3 (OSRAM) |
| JP (1) | JPS57500982A (OSRAM) |
| AU (1) | AU7221881A (OSRAM) |
| CA (1) | CA1156650A (OSRAM) |
| DK (1) | DK27282A (OSRAM) |
| NO (1) | NO820122L (OSRAM) |
| WO (1) | WO1981003277A1 (OSRAM) |
| ZA (1) | ZA813468B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0176316A3 (en) * | 1984-09-18 | 1989-04-26 | Toa Nenryo Kogyo Kabushiki Kaisha | A process for the production of a non woven fabric of water soluble resin fibres |
| CA2070589C (en) * | 1991-12-19 | 2000-11-28 | Kimberly-Clark Corporation | Method of preparing a nonwoven web of poly (vinyl alcohol) fibers |
| JPH06242106A (ja) * | 1993-02-01 | 1994-09-02 | Becton Dickinson & Co | 採血器具 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB899329A (en) * | 1959-10-16 | 1962-06-20 | Harold Edward Bell | Negative pressure unit for blood sampling |
| SE306597B (OSRAM) * | 1964-12-17 | 1968-12-02 | Incentive Ab | |
| US3673612A (en) * | 1970-08-28 | 1972-07-04 | Massachusetts Inst Technology | Non-thrombogenic materials and methods for their preparation |
| US4178941A (en) * | 1975-01-20 | 1979-12-18 | Concord Laboratories, Inc. | Method for drawing a blood sample |
| US4048064A (en) * | 1976-04-23 | 1977-09-13 | Clark Iii William T | Biocompatible hemoperfusion system |
| US4073723A (en) * | 1976-11-15 | 1978-02-14 | Swank Roy L | Anti-coagulating and filtering blood |
| CA1074698A (en) * | 1977-12-19 | 1980-04-01 | Gail A. Rock | Method of collecting anti-hemophilic factor viii from blood and blood plasma |
| DE2806515C2 (de) * | 1978-02-16 | 1983-08-11 | Gödecke AG, 1000 Berlin | Amorphes Heparin-Natrium und Verfahren zu dessen Herstellung |
-
1981
- 1981-04-20 WO PCT/US1981/000522 patent/WO1981003277A1/en not_active Ceased
- 1981-04-20 JP JP56501940A patent/JPS57500982A/ja active Pending
- 1981-04-20 AU AU72218/81A patent/AU7221881A/en not_active Abandoned
- 1981-04-24 EP EP81301825A patent/EP0041771A3/en not_active Ceased
- 1981-05-06 CA CA000376962A patent/CA1156650A/en not_active Expired
- 1981-05-22 ZA ZA00813468A patent/ZA813468B/xx unknown
-
1982
- 1982-01-15 NO NO820122A patent/NO820122L/no unknown
- 1982-01-22 DK DK27282A patent/DK27282A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0041771A2 (en) | 1981-12-16 |
| ZA813468B (en) | 1982-06-30 |
| WO1981003277A1 (en) | 1981-11-26 |
| DK27282A (da) | 1982-01-22 |
| JPS57500982A (OSRAM) | 1982-06-03 |
| NO820122L (no) | 1982-01-15 |
| AU7221881A (en) | 1981-12-07 |
| EP0041771A3 (en) | 1982-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4479799A (en) | Hypodermic syringe containing microfibers of an amorphous heparin salt | |
| US6333108B1 (en) | Cellulose fibre compositions | |
| EP0941377B1 (en) | Multicomponent fiber | |
| Hawn et al. | The fine structure of clots formed from purified bovine fibrinogen and thrombin: A study with the electron microscope | |
| CA1181206A (en) | Hollow fibre membrane for plasma separation | |
| US4353996A (en) | Bio-compatible porous fibres and materials for occluding biologically interesting substances, and method for their manufacture | |
| CN100422402C (zh) | 实心再生标准粘胶纤维 | |
| MXPA03000611A (es) | Metodos para hacer una composicion termoplastica biodegradable. | |
| WO2001014621A1 (en) | Biodisintegratable nonwovens with fluid management properties and disposable absorbent products containing same | |
| US10613068B2 (en) | Colorimetric sensor material for detecting hydrogen sulfide gas, which includes one-dimensional polymer nanofiber coupled to lead acetate particles obtained by high temperature stirring and quenching, and method of the same | |
| CN109260500A (zh) | 使用了羧甲基纤维素的医疗用材料 | |
| CA1156650A (en) | Heparin web and process | |
| Walther et al. | Physico-chemical analysis of electrospun fibers–A systematic approach | |
| US4405612A (en) | Heparin web compositions | |
| WO1989001062A1 (en) | Cellulosic fibre | |
| Liu et al. | Diffusion competition between solvent and nonsolvent during the coagulation process of cellulose/ammonia/ammonium thiocynate fiber spinning system | |
| US5955371A (en) | Apparatus for inhibiting glycolysis in blood samples | |
| CA2072176C (en) | Reagent for coagulating blood | |
| CN108721696A (zh) | 一种人工血管用高机械强度型纤维膜材料的制备方法 | |
| Yao et al. | Electro-blown spinning of hygroscopic breathable fabrics with patterned antisymmetrical wettability for visualized health state diagnosis | |
| US6245244B1 (en) | Method and kit for separating plasma from whole blood | |
| US20020182742A1 (en) | Examination method of buffer capacity of saliva and examination instrument of buffer capacity of saliva | |
| JPH03121052A (ja) | 毛細血管血液サンプル採取用の細管及びその製法 | |
| RU2174167C2 (ru) | Многокомпонентное волокно | |
| Harland | 41—The Degree of Polymerization and its Distribution in Cellulose Rayons—Parts I and II |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |