CA1156235A - 1-(8-quinolyl)-2-pyrrolidinone - Google Patents

1-(8-quinolyl)-2-pyrrolidinone

Info

Publication number
CA1156235A
CA1156235A CA000365722A CA365722A CA1156235A CA 1156235 A CA1156235 A CA 1156235A CA 000365722 A CA000365722 A CA 000365722A CA 365722 A CA365722 A CA 365722A CA 1156235 A CA1156235 A CA 1156235A
Authority
CA
Canada
Prior art keywords
formula
quinolyl
compound
pyrrolidinone
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000365722A
Other languages
English (en)
French (fr)
Inventor
Gordon L. Hodgson, Jr.
Thomas K. Shumaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of CA1156235A publication Critical patent/CA1156235A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA000365722A 1979-11-30 1980-11-28 1-(8-quinolyl)-2-pyrrolidinone Expired CA1156235A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7941409 1979-11-30
GB7941409 1979-11-30

Publications (1)

Publication Number Publication Date
CA1156235A true CA1156235A (en) 1983-11-01

Family

ID=10509524

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000365722A Expired CA1156235A (en) 1979-11-30 1980-11-28 1-(8-quinolyl)-2-pyrrolidinone

Country Status (18)

Country Link
US (1) US4366158A (OSRAM)
EP (1) EP0030023A3 (OSRAM)
JP (1) JPS5699475A (OSRAM)
KR (1) KR830004293A (OSRAM)
AR (1) AR228442A1 (OSRAM)
AT (1) AT375363B (OSRAM)
AU (1) AU6495080A (OSRAM)
CA (1) CA1156235A (OSRAM)
DK (1) DK506480A (OSRAM)
ES (1) ES8203882A1 (OSRAM)
FI (1) FI803704L (OSRAM)
GB (1) GB2063868B (OSRAM)
GR (1) GR71918B (OSRAM)
HU (1) HU185224B (OSRAM)
IL (1) IL61580A (OSRAM)
IT (1) IT1221040B (OSRAM)
NZ (1) NZ195688A (OSRAM)
ZA (1) ZA807467B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1558582T3 (pl) 2003-07-22 2006-05-31 Arena Pharm Inc Diarylowe i aryloheteroarylowe pochodne mocznika jako modulatory receptora serotoninowego 5-HT2A użyteczne w profilaktyce i w leczeniu zaburzeń związanych z tym receptorem
GB0507198D0 (en) * 2005-04-08 2005-05-18 Sb Pharmco Inc Process for preparing bicyclic compounds
GB0519758D0 (en) * 2005-09-28 2005-11-09 Glaxo Group Ltd Novel process
US9084742B2 (en) 2007-12-12 2015-07-21 Axovant Sciences Ltd. Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
MX388281B (es) 2015-06-12 2025-03-11 Axovant Sciences Gmbh Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamiento de un trastorno conductual del sueño rem.
CA2992518A1 (en) 2015-07-15 2017-01-19 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease

Also Published As

Publication number Publication date
AT375363B (de) 1984-07-25
IT1221040B (it) 1990-06-21
IL61580A (en) 1984-06-29
IT8050277A0 (it) 1980-11-28
DK506480A (da) 1981-05-31
ES497242A0 (es) 1982-04-01
ES8203882A1 (es) 1982-04-01
GR71918B (OSRAM) 1983-08-17
AR228442A1 (es) 1983-03-15
FI803704A7 (fi) 1981-05-31
IL61580A0 (en) 1980-12-31
HU185224B (en) 1984-12-28
EP0030023A3 (en) 1981-09-02
KR830004293A (ko) 1983-07-09
ATA582780A (de) 1983-12-15
JPS5699475A (en) 1981-08-10
NZ195688A (en) 1984-09-28
EP0030023A2 (en) 1981-06-10
GB2063868A (en) 1981-06-10
FI803704L (fi) 1981-05-31
US4366158A (en) 1982-12-28
GB2063868B (en) 1984-02-29
AU6495080A (en) 1981-06-04
ZA807467B (en) 1982-07-28

Similar Documents

Publication Publication Date Title
USRE33024E (en) Bronchodilating 8-hydroxy-5-(1R)-1-hydroxy-2-(N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)-amino)ethyl) carbostyril and intermediates thereof
RU2136682C1 (ru) Имидазопиридины, способ их получения, фармацевтическая композиция на их основе и способ получения фармацевтической композиции
US4022776A (en) 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives
US4232038A (en) 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
EP0008755A1 (en) Antiinflammatory 4,5-diaryl-2-nitroimidazoles, method for their preparation and pharmaceutical composition containing them
EP0034798B1 (en) Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones
JP2007503423A (ja) フェキソフェナジンの結晶多形、及びそれらを製造する方法
CA1156235A (en) 1-(8-quinolyl)-2-pyrrolidinone
US4344943A (en) 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
KR850000216B1 (ko) 피페라진 유도체의 제조방법
US4652582A (en) Antiinflammatory-2-halo-4,5-diarylpyrroles
EP0015156A1 (en) Basically-substituted tricyclic pyrazoles, their preparation and their use as antiinflammatory agents
US4168380A (en) 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
EP0005156B1 (en) 4,5-diaryl-2-(substituted-thio)-pyrroles and their corresponding sulfoxides and sulfones, process for their preparation and pharmaceutical compositions containing them
EP0270692A1 (en) Antiarrhythmic agent
US3972994A (en) Disubstituted azabicycloalkanes
EP0279398B1 (en) Antifungal 2-anilinothiazolines
EP0065082B1 (en) Pyrrolidinone derivatives, their preparation and pharmaceutical compositions containing them
JPH0789966A (ja) ピロロ〔１，２−ａ〕〔４，１〕ベンゾオキサゼピン誘導体
US3878215A (en) 2-Alkyl-3-substituted-4-aryl isoquinolines
EP0045602B1 (en) Novel polycyclic indole derivatives
JPH027952B2 (OSRAM)
US4126625A (en) Certain 5-substituted-3-methyl-2-benzofuran acetic acids
EP0794184A1 (en) 6-methoxy-1h-benzotriazole-5-carboxamide derivatives, process for producing the same, and medicinal composition containing the same
US4010161A (en) Piperazinoethyl-N-(2,3-dimethyl-5-oxo-1-phenyl-3Δ-pyrazolin-4-yl)carbamates

Legal Events

Date Code Title Description
MKEX Expiry