CA1154679A - Use of dihydro-1h-pyrrolizine-3,5(2h,6h)-dione as a cognition activator - Google Patents

Use of dihydro-1h-pyrrolizine-3,5(2h,6h)-dione as a cognition activator

Info

Publication number
CA1154679A
CA1154679A CA000385964A CA385964A CA1154679A CA 1154679 A CA1154679 A CA 1154679A CA 000385964 A CA000385964 A CA 000385964A CA 385964 A CA385964 A CA 385964A CA 1154679 A CA1154679 A CA 1154679A
Authority
CA
Canada
Prior art keywords
dihydro
dione
pyrrolizine
grams
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000385964A
Other languages
English (en)
French (fr)
Inventor
Donald E. Butler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of CA1154679A publication Critical patent/CA1154679A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA000385964A 1980-09-15 1981-09-15 Use of dihydro-1h-pyrrolizine-3,5(2h,6h)-dione as a cognition activator Expired CA1154679A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18694580A 1980-09-15 1980-09-15
US186,945 1980-09-15
US06/290,114 US4372966A (en) 1980-09-15 1981-08-07 Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator
US290,114 1981-08-07

Publications (1)

Publication Number Publication Date
CA1154679A true CA1154679A (en) 1983-10-04

Family

ID=26882585

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000385964A Expired CA1154679A (en) 1980-09-15 1981-09-15 Use of dihydro-1h-pyrrolizine-3,5(2h,6h)-dione as a cognition activator

Country Status (15)

Country Link
US (1) US4372966A (enExample)
EP (1) EP0048132B1 (enExample)
AU (1) AU545556B2 (enExample)
CA (1) CA1154679A (enExample)
DD (1) DD201797A5 (enExample)
DE (1) DE3165563D1 (enExample)
ES (1) ES8206526A1 (enExample)
FI (1) FI812853A7 (enExample)
GR (1) GR75026B (enExample)
HU (1) HU184883B (enExample)
IE (1) IE51514B1 (enExample)
IL (1) IL63663A (enExample)
NO (1) NO813122L (enExample)
NZ (1) NZ198342A (enExample)
PH (1) PH18690A (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547519A (en) * 1982-05-24 1985-10-15 Warner-Lambert Company Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acid and benzyl esters and amides thereof and their use in reversing amnesia
US4559358A (en) * 1982-05-24 1985-12-17 Warner-Lambert Company 5-Oxo-2-pyrrolidinepropanoic acid and derivatives for reversing electroshock amnesia
US4525476A (en) * 1983-05-26 1985-06-25 Warner-Lambert Company N-[1-oxo-3-(5-oxo-2-pyrrolidinyl)propyl]-alpha-aminoacids and derivatives as cognition activators
US4551470A (en) * 1983-08-29 1985-11-05 Warner-Lambert Company Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid and derivatives, and use for reversing electroconvulsive shock amnesia
US4530929A (en) * 1984-02-02 1985-07-23 Warner-Lambert Company Benzotricyclic nitrogen-containing diones and their use in reversing electroconvulsive shock-induced amnesia
US4562195A (en) * 1984-02-02 1985-12-31 Warner-Lambert Company Reversing amnesia with saturated tricyclic nitrogen-containing diones
US4548947A (en) * 1984-05-07 1985-10-22 Warner-Lambert Company 1-(Substituted-aryl)-dihydro-1H-pyrrolizine-3,5-[2H,6H-]diones and use for reversing amnesia
US4677098A (en) * 1985-11-22 1987-06-30 Warner-Lambert Company Substituted dihydro-1H-pyrolizine-3,5(2H,6H)-diones
US4663464A (en) * 1986-03-21 1987-05-05 Warner-Lambert Company Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione
IT1233860B (it) * 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa

Also Published As

Publication number Publication date
EP0048132A2 (en) 1982-03-24
GR75026B (enExample) 1984-07-12
EP0048132B1 (en) 1984-08-15
AU7479981A (en) 1982-03-25
ES505456A0 (es) 1982-08-16
NZ198342A (en) 1984-11-09
FI812853L (fi) 1982-03-16
DD201797A5 (de) 1983-08-10
IE812133L (en) 1982-03-15
FI812853A7 (fi) 1982-03-16
HU184883B (en) 1984-10-29
ES8206526A1 (es) 1982-08-16
EP0048132A3 (en) 1982-05-12
NO813122L (no) 1982-03-16
AU545556B2 (en) 1985-07-18
IL63663A0 (en) 1981-11-30
PH18690A (en) 1985-09-05
US4372966A (en) 1983-02-08
DE3165563D1 (en) 1984-09-20
IE51514B1 (en) 1987-01-07
IL63663A (en) 1984-12-31

Similar Documents

Publication Publication Date Title
US5472707A (en) High dose ranolazine formulations
CA1154679A (en) Use of dihydro-1h-pyrrolizine-3,5(2h,6h)-dione as a cognition activator
EP0043659B1 (en) Clonidine derivatives useful in the treatment of diarrhoea
CA1161853A (en) N-lower-alkyl 3-phenoxy-1-azetidine-carboxamides
US4505926A (en) Quaternary amino imidazolidines, compositions and use
US3830816A (en) 1-cyclopropylmethyleneamino-3,4-dihydroisoquinoline and acid addition salts thereof
EP0118036A1 (en) Biologically active ketone derivative, preparation and use
US3867391A (en) Cyclic n-substituted derivatives of 1,4-benzene disulphonamide
DE2259282A1 (de) Neue aminoaethanole
JPS6479186A (en) Ester substituted thienotriazolodiazepine compound and medicinal use thereof
US4312879A (en) Clonidine and lofexidine as antidiarrheal agents
CA1158558A (en) Antidiarrhoeal agents
DE2513136C3 (de) N-(1-Benzylpiperid-4-yl)-benzamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
DE2034640C3 (de) l-p-(7-Trifluormethyl-4-chinolyl) -amino-benzoyl-piperazine, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Bekämpfung von Bluthochdruck
DE3904795C2 (de) Pharmazeutisches Präparat und dessen Verwendung
US5080905A (en) Therapy of 10-amino-5,6-dihydro-11h-dibenzo(b,e)azepine-6,11-dione and derivatives as drugs for use in the treatment of urinary incontinence
US4666922A (en) Method for modulating the immune response
CA2442468A1 (en) Therapeutic agent for bladder hypersensitivity
EP0260527B1 (de) Neue synergistische Kombination bestehend aus einem Phosphodiesterase-Hemmer und einem Tromboxan-A2-Antagonisten und deren Verwendung bzw. Herstellung
US3864486A (en) Therapeutic compositions of bromazepam and sulpiride
US3314855A (en) Antidepressant compositions and methods of using same
DE2407016B2 (de) 2-Alkoxybenzoylaminocarbonsäuren, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antipyretische Mittel
US4363809A (en) Organic compounds
US4614743A (en) Methods of treating pain and inflammation with 4,7-dimethyl-2-(4-pyridinyl)-1,2,4,-triazolo[1,5-a]pyrimidin-5(4H)-one or the pharmaceutically acceptable salts or solvates thereof
US4443474A (en) Pharmaceutical N-phenyl carbamoyl glycinate compositions

Legal Events

Date Code Title Description
MKEX Expiry