CA1136444A - Liquid chromatography - Google Patents
Liquid chromatographyInfo
- Publication number
- CA1136444A CA1136444A CA000354497A CA354497A CA1136444A CA 1136444 A CA1136444 A CA 1136444A CA 000354497 A CA000354497 A CA 000354497A CA 354497 A CA354497 A CA 354497A CA 1136444 A CA1136444 A CA 1136444A
- Authority
- CA
- Canada
- Prior art keywords
- improvement
- light
- light source
- measurement
- modulating means
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004811 liquid chromatography Methods 0.000 title description 3
- 238000005259 measurement Methods 0.000 claims abstract description 27
- 230000033001 locomotion Effects 0.000 claims abstract description 22
- 230000006872 improvement Effects 0.000 claims description 23
- 230000003287 optical effect Effects 0.000 claims description 22
- 238000000576 coating method Methods 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 4
- 238000005065 mining Methods 0.000 claims 1
- 230000008859 change Effects 0.000 abstract description 8
- 230000004044 response Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 238000010408 sweeping Methods 0.000 abstract description 4
- 239000003990 capacitor Substances 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 abstract description 3
- 238000004904 shortening Methods 0.000 abstract description 2
- 230000002411 adverse Effects 0.000 abstract 1
- 238000007599 discharging Methods 0.000 abstract 1
- 239000000835 fiber Substances 0.000 description 19
- 239000007788 liquid Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 239000004593 Epoxy Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000005388 borosilicate glass Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 241001163743 Perlodes Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241001080526 Vertica Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 229920006334 epoxy coating Polymers 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003455 independent Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000009428 plumbing Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/4133—Refractometers, e.g. differential
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D3/00—Indicating or recording apparatus with provision for the special purposes referred to in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000403939A CA1141192A (en) | 1979-01-02 | 1982-05-27 | Measurement of refractivity changes |
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50,326 | 1979-06-20 | ||
| US06/050,326 US4284352A (en) | 1979-06-20 | 1979-06-20 | Heat exchanger for refractometer |
| US5181079A | 1979-06-25 | 1979-06-25 | |
| US06/051,809 US4265536A (en) | 1979-06-25 | 1979-06-25 | Electrical zeroing of light beam |
| US06/051,812 US4283140A (en) | 1979-06-25 | 1979-06-25 | Spatially homogenizing optical modulator |
| US51,810 | 1979-06-25 | ||
| US51,811 | 1979-06-25 | ||
| US51,812 | 1979-06-25 | ||
| US06/051,811 US4286873A (en) | 1979-06-25 | 1979-06-25 | Refractometer cell with integral lens |
| US51,809 | 1979-06-25 | ||
| US59,292 | 1979-07-20 | ||
| US06/059,292 US4289975A (en) | 1979-07-20 | 1979-07-20 | Dissipating electrical charge |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1136444A true CA1136444A (en) | 1982-11-30 |
Family
ID=27556617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000354497A Expired CA1136444A (en) | 1979-01-02 | 1980-06-20 | Liquid chromatography |
Country Status (4)
| Country | Link |
|---|---|
| CA (1) | CA1136444A (enrdf_load_stackoverflow) |
| DE (2) | DE3023132A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2459470B1 (enrdf_load_stackoverflow) |
| GB (2) | GB2068539B (enrdf_load_stackoverflow) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3618605A1 (de) * | 1986-06-03 | 1987-12-10 | Europ Lab Molekularbiolog | Vorrichtung zur detektion von zur photonenemission anregbaren stoffen |
| DE69026592T2 (de) * | 1990-01-24 | 1996-09-12 | Hewlett Packard Gmbh | Vorrichtung zur Temperaturregelung der mobilen Phase in einem Flüssigchromatographen |
| US5238557A (en) * | 1990-01-24 | 1993-08-24 | Hewlett Packard Company | Apparatus for controlling the temperature of the mobile phase in a fluid chromatograph |
| JP3574010B2 (ja) * | 1999-07-23 | 2004-10-06 | 昭和電工株式会社 | 示差屈折率検出器及びそれを備えた液体クロマトグラフ装置 |
| EP1182453B1 (en) | 2000-06-27 | 2007-08-15 | Agilent Technologies, Inc. | Method of reducing the effects of varying environmental conditions in a measuring instrument and measuring instrument using the method |
| FR3008188B1 (fr) * | 2013-07-03 | 2015-08-07 | Sedere Sas | Detecteur evaporatif a diffusion de lumiere (dedl) destine a etre couple a une colonne de chromatographie en phase liquide ou supercritique ainsi que procede de gestion dynamique automatique d'un tel dedl |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2649013A (en) * | 1950-06-05 | 1953-08-18 | Monsanto Chemicals | Apparatus for refractometry |
| US2885923A (en) * | 1954-08-13 | 1959-05-12 | Phillips Petroleum Co | Reflection refractometer |
| US2807976A (en) * | 1955-10-11 | 1957-10-01 | Electron Machine Corp | Refractometer |
| US2957386A (en) * | 1957-01-28 | 1960-10-25 | Cons Electrodynamics Corp | Refractometer |
| US3386332A (en) * | 1964-07-13 | 1968-06-04 | Emmett S. Watson | Differential refractometry |
| US3674373A (en) * | 1970-02-02 | 1972-07-04 | Waters Associates Inc | Differential refractometer |
| US3999857A (en) * | 1975-05-29 | 1976-12-28 | Monsanto Research Corporation | Refractive index detector |
| CA1074149A (en) * | 1976-03-02 | 1980-03-25 | Sadao Sumikama | High-sensitivity differential refractometer |
| DE2755849A1 (de) * | 1977-12-15 | 1979-06-21 | Philips Patentverwaltung | Verfahren und anordnung zur kontinuierlichen messung von brechungsindizes |
-
1980
- 1980-06-20 DE DE19803023132 patent/DE3023132A1/de active Granted
- 1980-06-20 CA CA000354497A patent/CA1136444A/en not_active Expired
- 1980-06-20 GB GB8103589A patent/GB2068539B/en not_active Expired
- 1980-06-20 DE DE19803044076 patent/DE3044076A1/de not_active Withdrawn
- 1980-06-20 FR FR8013807A patent/FR2459470B1/fr not_active Expired
- 1980-06-20 GB GB8020276A patent/GB2054842B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3023132A1 (de) | 1981-02-19 |
| DE3044076A1 (de) | 1982-12-02 |
| GB2054842A (en) | 1981-02-18 |
| GB2054842B (en) | 1983-11-30 |
| FR2459470B1 (fr) | 1985-06-21 |
| GB2068539A (en) | 1981-08-12 |
| DE3023132C2 (enrdf_load_stackoverflow) | 1991-10-31 |
| GB2068539B (en) | 1983-06-22 |
| FR2459470A1 (fr) | 1981-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |