CA1129414A - Substituted piperazines and piperidines having immune regulant activity - Google Patents

Substituted piperazines and piperidines having immune regulant activity

Info

Publication number
CA1129414A
CA1129414A CA355,613A CA355613A CA1129414A CA 1129414 A CA1129414 A CA 1129414A CA 355613 A CA355613 A CA 355613A CA 1129414 A CA1129414 A CA 1129414A
Authority
CA
Canada
Prior art keywords
benzyl
compound
formula
process according
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA355,613A
Other languages
English (en)
French (fr)
Inventor
Joseph G. Lombardino
Allen R. Kraska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/055,936 external-priority patent/US4255426A/en
Priority claimed from US06/146,846 external-priority patent/US4357332A/en
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Application granted granted Critical
Publication of CA1129414A publication Critical patent/CA1129414A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/15—Unsaturated ethers containing only non-aromatic carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CA355,613A 1979-07-09 1980-07-07 Substituted piperazines and piperidines having immune regulant activity Expired CA1129414A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/055,936 US4255426A (en) 1979-07-09 1979-07-09 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines
US55,936 1979-07-09
US06/146,846 US4357332A (en) 1980-05-05 1980-05-05 Substituted piperazines having immune regulant activity
US146,846 1980-05-05

Publications (1)

Publication Number Publication Date
CA1129414A true CA1129414A (en) 1982-08-10

Family

ID=26734776

Family Applications (1)

Application Number Title Priority Date Filing Date
CA355,613A Expired CA1129414A (en) 1979-07-09 1980-07-07 Substituted piperazines and piperidines having immune regulant activity

Country Status (14)

Country Link
EP (1) EP0022371B1 (oth)
AR (1) AR226701A1 (oth)
AU (1) AU520364B2 (oth)
CA (1) CA1129414A (oth)
DE (1) DE3061680D1 (oth)
DK (1) DK293480A (oth)
ES (1) ES8105285A1 (oth)
FI (1) FI74958C (oth)
GR (1) GR69332B (oth)
IE (1) IE49952B1 (oth)
IL (1) IL60518A (oth)
PH (1) PH16763A (oth)
PT (1) PT71509A (oth)
YU (1) YU41932B (oth)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319534D0 (en) * 1993-09-22 1993-11-10 Boots Co Plc Therapeutic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE570307A (oth) *
GB1119835A (en) * 1964-07-20 1968-07-17 Analyses Et De Rech S Biolog M Process for the preparation of basic ethers
US4166132A (en) * 1977-08-18 1979-08-28 Pfizer Inc. Antiviral amine derivatives of glycerol and propanediols

Also Published As

Publication number Publication date
EP0022371B1 (en) 1983-01-19
GR69332B (oth) 1982-05-17
YU173580A (en) 1983-06-30
FI74958B (fi) 1987-12-31
DE3061680D1 (en) 1983-02-24
ES493212A0 (es) 1981-05-16
PT71509A (en) 1980-08-01
FI802184A7 (fi) 1981-01-10
IL60518A0 (en) 1980-09-16
PH16763A (en) 1984-02-15
IE49952B1 (en) 1986-01-22
IL60518A (en) 1983-11-30
YU41932B (en) 1988-02-29
DK293480A (da) 1981-01-10
AU6020480A (en) 1981-01-15
AU520364B2 (en) 1982-01-28
AR226701A1 (es) 1982-08-13
IE801411L (en) 1981-01-09
EP0022371A1 (en) 1981-01-14
ES8105285A1 (es) 1981-05-16
FI74958C (fi) 1988-04-11

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