CA1109796A - Process for the production of novel antidiarrheal agents - Google Patents
Process for the production of novel antidiarrheal agentsInfo
- Publication number
- CA1109796A CA1109796A CA294,379A CA294379A CA1109796A CA 1109796 A CA1109796 A CA 1109796A CA 294379 A CA294379 A CA 294379A CA 1109796 A CA1109796 A CA 1109796A
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical preparation
- active ingredient
- encephaline
- administration
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 235000011167 hydrochloric acid Nutrition 0.000 description 1
- 230000003165 hydrotropic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910003480 inorganic solid Inorganic materials 0.000 description 1
- 238000007914 intraventricular administration Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 description 1
- 229960001571 loperamide Drugs 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000003791 organic solvent mixture Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000011369 resultant mixture Substances 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU76538 | 1977-01-07 | ||
| LU76538A LU76538A1 (enrdf_load_html_response) | 1977-01-07 | 1977-01-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1109796A true CA1109796A (en) | 1981-09-29 |
Family
ID=19728442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA294,379A Expired CA1109796A (en) | 1977-01-07 | 1978-01-05 | Process for the production of novel antidiarrheal agents |
Country Status (13)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5783193A (en) * | 1991-06-21 | 1998-07-21 | The University Of Cincinnati | Oral administration of therapeutic proteins for treatment of autoimmune disease, transplant rejection and infectious disease |
| US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668517A (en) * | 1985-04-04 | 1987-05-26 | Norwich Eaton Pharmaceuticals, Inc. | Furazolidone dosage form |
| NL8503413A (nl) * | 1985-12-11 | 1987-07-01 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Preparaten ter bestrijding van diarrhee. |
-
1977
- 1977-01-07 LU LU76538A patent/LU76538A1/xx unknown
-
1978
- 1978-01-02 NL NL7800045A patent/NL7800045A/xx not_active Application Discontinuation
- 1978-01-03 DE DE19782800110 patent/DE2800110A1/de not_active Withdrawn
- 1978-01-05 CA CA294,379A patent/CA1109796A/en not_active Expired
- 1978-01-05 GB GB340/78A patent/GB1595021A/en not_active Expired
- 1978-01-05 FR FR7800206A patent/FR2376663A1/fr active Granted
- 1978-01-06 IL IL53760A patent/IL53760A/xx unknown
- 1978-01-06 IT IT7847545A patent/IT7847545A0/it unknown
- 1978-01-06 IE IE32/78A patent/IE46241B1/en unknown
- 1978-01-06 ZA ZA00780087A patent/ZA7887B/xx unknown
- 1978-01-06 BE BE184140A patent/BE862689A/xx unknown
- 1978-01-06 AU AU32217/78A patent/AU3221778A/en active Pending
- 1978-01-07 JP JP39678A patent/JPS5388332A/ja active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5783193A (en) * | 1991-06-21 | 1998-07-21 | The University Of Cincinnati | Oral administration of therapeutic proteins for treatment of autoimmune disease, transplant rejection and infectious disease |
| US6174529B1 (en) | 1991-06-21 | 2001-01-16 | University Of Cincinnati | Oral therapy for the treatment of allergies and method of manufacture |
| US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5388332A (en) | 1978-08-03 |
| LU76538A1 (enrdf_load_html_response) | 1978-09-18 |
| NL7800045A (nl) | 1978-07-11 |
| IL53760A (en) | 1981-07-31 |
| AU3221778A (en) | 1979-07-12 |
| IE46241B1 (en) | 1983-04-06 |
| IT7847545A0 (it) | 1978-01-06 |
| FR2376663A1 (fr) | 1978-08-04 |
| ZA7887B (en) | 1978-11-29 |
| IE780032L (en) | 1978-07-07 |
| IL53760A0 (en) | 1978-04-30 |
| FR2376663B1 (enrdf_load_html_response) | 1981-11-20 |
| GB1595021A (en) | 1981-08-05 |
| BE862689A (fr) | 1978-07-06 |
| DE2800110A1 (de) | 1978-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |