CA1108074A - Fortimicin factors d and ke and processes for production thereof - Google Patents
Fortimicin factors d and ke and processes for production thereofInfo
- Publication number
- CA1108074A CA1108074A CA289,631A CA289631A CA1108074A CA 1108074 A CA1108074 A CA 1108074A CA 289631 A CA289631 A CA 289631A CA 1108074 A CA1108074 A CA 1108074A
- Authority
- CA
- Canada
- Prior art keywords
- fortimicin
- fractions
- factors
- micromonospora
- column
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BIDUPMYXGFNAEJ-APGVDKLISA-N astromicin Chemical compound O[C@@H]1[C@H](N(C)C(=O)CN)[C@@H](OC)[C@@H](O)[C@H](N)[C@H]1O[C@@H]1[C@H](N)CC[C@@H]([C@H](C)N)O1 BIDUPMYXGFNAEJ-APGVDKLISA-N 0.000 title claims abstract description 46
- 229930195503 Fortimicin Natural products 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims abstract description 32
- 238000004519 manufacturing process Methods 0.000 title description 5
- VYLDQCCRMFPJHA-FXJXLBQDSA-N CO[C@H]1[C@@H](O)[C@H](N)[C@@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@H](O)[C@@H]1N(C)C(=O)CN Chemical compound CO[C@H]1[C@@H](O)[C@H](N)[C@@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@H](O)[C@@H]1N(C)C(=O)CN VYLDQCCRMFPJHA-FXJXLBQDSA-N 0.000 claims abstract description 55
- VYLDQCCRMFPJHA-UHFFFAOYSA-N Fortimicin D Natural products OC1C(N(C)C(=O)CN)C(OC)C(O)C(N)C1OC1C(N)CCC(CN)O1 VYLDQCCRMFPJHA-UHFFFAOYSA-N 0.000 claims abstract description 55
- SPZPNNYPYCPIPT-UHFFFAOYSA-N Fortimicin KE Natural products NC1C(O)C(OC)C(NC)C(O)C1OC1C(N)CCC(CN)O1 SPZPNNYPYCPIPT-UHFFFAOYSA-N 0.000 claims abstract description 47
- SPZPNNYPYCPIPT-SDOPNMJFSA-N CN[C@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@@H](N)[C@H](O)[C@@H]1OC Chemical compound CN[C@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@@H](N)[C@H](O)[C@@H]1OC SPZPNNYPYCPIPT-SDOPNMJFSA-N 0.000 claims abstract description 46
- 241000187708 Micromonospora Species 0.000 claims abstract description 20
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- 239000002253 acid Substances 0.000 claims description 7
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- 235000015097 nutrients Nutrition 0.000 claims description 5
- 231100000252 nontoxic Toxicity 0.000 claims description 3
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- 229910001868 water Inorganic materials 0.000 description 31
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 30
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 16
- 239000012458 free base Substances 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
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- WFMQYKIRAVMXSU-UHFFFAOYSA-N Fortimicin AE Natural products NC1C(O)C(OC)C(NC)C(O)C1OC1C(N)CCC(C(C)N)O1 WFMQYKIRAVMXSU-UHFFFAOYSA-N 0.000 description 13
- WFMQYKIRAVMXSU-LCVFDZPESA-N Fortimicin B Chemical compound N[C@H]1[C@H](O)[C@H](OC)[C@@H](NC)[C@@H](O)[C@@H]1O[C@@H]1[C@H](N)CC[C@@H]([C@H](C)N)O1 WFMQYKIRAVMXSU-LCVFDZPESA-N 0.000 description 13
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
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- 229910021529 ammonia Inorganic materials 0.000 description 10
- DLVFJQXRKNWSCB-CPLRHSGFSA-N Fortimicin C Natural products CO[C@H]1[C@@H](O)[C@H](N)[C@H](O[C@H]2O[C@@H](CN)CC[C@@H]2N)[C@@H](O)[C@H]1N(C)C(=O)CNC(=O)N DLVFJQXRKNWSCB-CPLRHSGFSA-N 0.000 description 9
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- 229960002518 gentamicin Drugs 0.000 description 9
- VKGIGFQBOYWLHV-APGVDKLISA-N n-[(1s,2r,3r,4s,5s,6r)-4-amino-3-[(2r,3r,6s)-3-amino-6-[(1s)-1-aminoethyl]oxan-2-yl]oxy-2,5-dihydroxy-6-methoxycyclohexyl]-2-(carbamoylamino)-n-methylacetamide Chemical compound O[C@@H]1[C@H](N(C)C(=O)CNC(N)=O)[C@@H](OC)[C@@H](O)[C@H](N)[C@H]1O[C@@H]1[C@H](N)CC[C@@H]([C@H](C)N)O1 VKGIGFQBOYWLHV-APGVDKLISA-N 0.000 description 9
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- URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 description 7
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- VEGXETMJINRLTH-BOZYPMBZSA-N gentamycin C1a Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N VEGXETMJINRLTH-BOZYPMBZSA-N 0.000 description 7
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- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 5
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/863—Mycobacterium
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP128,837/76 | 1976-10-28 | ||
| JP51128837A JPS5834119B2 (ja) | 1976-10-28 | 1976-10-28 | 新抗生物質ホ−テイマイシンｄおよびその製造法 |
| JP233877A JPS5390241A (en) | 1977-01-14 | 1977-01-14 | Novel antibiotics fortemycin |
| JP2338/77 | 1977-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1108074A true CA1108074A (en) | 1981-09-01 |
Family
ID=26335697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA289,631A Expired CA1108074A (en) | 1976-10-28 | 1977-10-27 | Fortimicin factors d and ke and processes for production thereof |
Country Status (13)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6030320B2 (ja) * | 1978-01-13 | 1985-07-16 | 山之内製薬株式会社 | 新規抗生物質およびその製造法 |
| US4312858A (en) * | 1978-07-13 | 1982-01-26 | Kowa Company, Ltd. | Antibiotic KA-7038 and compositions containing same |
| US4380581A (en) * | 1979-05-01 | 1983-04-19 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Istamycins and streptomyces culture for the production thereof |
| DE3012014C2 (de) * | 1979-05-01 | 1986-11-13 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokio/Tokyo | Istamycine, Verfahren zu deren Herstellung sowie Verwendung derselben als antibakterielle Mittel |
| US4382926A (en) * | 1980-04-01 | 1983-05-10 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics |
| US4338309A (en) * | 1980-11-10 | 1982-07-06 | Abbott Laboratories | 4',5'-Dihydro-antibiotic AX-127B-1; 2'-N-des-β-lysyl-4',5'-dihydro-antibiotic AX-127B-1; and 4-N-derivatives thereof |
| US5604266A (en) * | 1992-10-15 | 1997-02-18 | Ecomat, Inc. | Cured unsaturated polyest-polyurethane highly filled resin materials and process for preparing them |
| US5508315A (en) * | 1992-10-15 | 1996-04-16 | Ecomat, Inc. | Cured unsaturated polyester-polyurethane hybrid highly filled resin foams |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976748A (en) * | 1972-10-09 | 1976-08-24 | Alkem Gmbh | Process for the production of 238 Pu 16 O2 |
| US3931400A (en) * | 1973-04-17 | 1976-01-06 | Abbott Laboratories | Fortimicin B and process for production thereof |
| US3878193A (en) * | 1973-06-26 | 1975-04-15 | Schering Corp | Process for the preparation of garamine derivatives |
| US3963695A (en) * | 1974-12-19 | 1976-06-15 | Smithkline Corporation | Tetradeoxyneamine and derivatives thereof |
| US4091032A (en) * | 1976-09-23 | 1978-05-23 | Abbott Laboratories | 4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A |
| US4124756A (en) * | 1976-12-27 | 1978-11-07 | Abbott Laboratories | 3-DE-O-Methylfortimicins |
-
1977
- 1977-10-25 NZ NZ185515A patent/NZ185515A/xx unknown
- 1977-10-25 GR GR54643A patent/GR66054B/el unknown
- 1977-10-27 PH PH20370A patent/PH14319A/en unknown
- 1977-10-27 US US05/845,970 patent/US4145253A/en not_active Expired - Lifetime
- 1977-10-27 FR FR7732525A patent/FR2369294A1/fr active Granted
- 1977-10-27 CA CA289,631A patent/CA1108074A/en not_active Expired
- 1977-10-27 GB GB44833/77A patent/GB1572530A/en not_active Expired
- 1977-10-27 DK DK478077A patent/DK145893C/da active
- 1977-10-27 NO NO773674A patent/NO149040C/no unknown
- 1977-10-28 ES ES463697A patent/ES463697A1/es not_active Expired
- 1977-10-28 DE DE2748530A patent/DE2748530C3/de not_active Expired
- 1977-10-28 AU AU30158/77A patent/AU516309B2/en not_active Expired
- 1977-10-28 AR AR269767A patent/AR219305A1/es active
-
1978
- 1978-12-29 US US05/974,434 patent/US4216308A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4216308A (en) | 1980-08-05 |
| AU516309B2 (en) | 1981-05-28 |
| NZ185515A (en) | 1980-08-26 |
| NO773674L (no) | 1978-05-02 |
| FR2369294B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-04-11 |
| GB1572530A (en) | 1980-07-30 |
| DE2748530A1 (de) | 1978-05-18 |
| DK478077A (da) | 1978-04-29 |
| FR2369294A1 (fr) | 1978-05-26 |
| GR66054B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-01-14 |
| AR219305A1 (es) | 1980-08-15 |
| AU3015877A (en) | 1979-05-03 |
| PH14319A (en) | 1981-05-27 |
| ES463697A1 (es) | 1979-07-16 |
| US4145253A (en) | 1979-03-20 |
| NO149040C (no) | 1984-02-01 |
| DK145893C (da) | 1983-10-31 |
| DE2748530B2 (de) | 1980-02-07 |
| DE2748530C3 (de) | 1980-10-09 |
| DK145893B (da) | 1983-04-05 |
| NO149040B (no) | 1983-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |