CA1096382A - PROCESSES FOR THE PREPARATION OF NEW ( ,-)-CIS-.alpha.- ¬3-(2,6-DIMETHYL-1-PIPERIDINYL)PROPYL|-.alpha.-PHENYL- 2-PYRIDINEMETHANOL COMPOUNDS - Google Patents

PROCESSES FOR THE PREPARATION OF NEW ( ,-)-CIS-.alpha.- ¬3-(2,6-DIMETHYL-1-PIPERIDINYL)PROPYL|-.alpha.-PHENYL- 2-PYRIDINEMETHANOL COMPOUNDS

Info

Publication number
CA1096382A
CA1096382A CA297,176A CA297176A CA1096382A CA 1096382 A CA1096382 A CA 1096382A CA 297176 A CA297176 A CA 297176A CA 1096382 A CA1096382 A CA 1096382A
Authority
CA
Canada
Prior art keywords
cis
alpha
acid
dimethyl
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA297,176A
Other languages
English (en)
French (fr)
Inventor
Robert W. Fleming
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/772,203 external-priority patent/US4112103A/en
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Application granted granted Critical
Publication of CA1096382A publication Critical patent/CA1096382A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA297,176A 1977-02-25 1978-02-17 PROCESSES FOR THE PREPARATION OF NEW ( ,-)-CIS-.alpha.- ¬3-(2,6-DIMETHYL-1-PIPERIDINYL)PROPYL|-.alpha.-PHENYL- 2-PYRIDINEMETHANOL COMPOUNDS Expired CA1096382A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US772,203 1977-02-25
US05/772,203 US4112103A (en) 1976-04-15 1977-02-25 Antiarrhythmic (+,-)-cis-α-[3-(2,6-dimethyl-1-piperidinyl)propyl]-α-phenyl-2-pyridinemethanols

Publications (1)

Publication Number Publication Date
CA1096382A true CA1096382A (en) 1981-02-24

Family

ID=25094280

Family Applications (1)

Application Number Title Priority Date Filing Date
CA297,176A Expired CA1096382A (en) 1977-02-25 1978-02-17 PROCESSES FOR THE PREPARATION OF NEW ( ,-)-CIS-.alpha.- ¬3-(2,6-DIMETHYL-1-PIPERIDINYL)PROPYL|-.alpha.-PHENYL- 2-PYRIDINEMETHANOL COMPOUNDS

Country Status (11)

Country Link
JP (1) JPS53105479A (de)
AT (1) AT358040B (de)
BE (1) BE864033A (de)
CA (1) CA1096382A (de)
CH (1) CH635095A5 (de)
DE (1) DE2806654A1 (de)
DK (1) DK143229C (de)
ES (1) ES467100A1 (de)
FR (1) FR2381761A1 (de)
GB (1) GB1581096A (de)
PH (1) PH13125A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2818914B2 (ja) * 1991-04-05 1998-10-30 シャープ株式会社 多目的スチーム発生器

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE757408A (fr) * 1969-10-13 1971-04-13 Thomae Gmbh Dr K Nouveaux butanols tertiaires a constituants basiques

Also Published As

Publication number Publication date
JPS6257632B2 (de) 1987-12-02
FR2381761B1 (de) 1982-03-26
DK143229B (da) 1981-07-27
FR2381761A1 (fr) 1978-09-22
CH635095A5 (en) 1983-03-15
DE2806654C2 (de) 1987-07-16
AT358040B (de) 1980-08-11
GB1581096A (en) 1980-12-10
DK143229C (da) 1981-11-30
PH13125A (en) 1979-12-12
ATA117078A (de) 1980-01-15
DE2806654A1 (de) 1978-08-31
BE864033A (fr) 1978-06-16
JPS53105479A (en) 1978-09-13
ES467100A1 (es) 1978-11-01
DK73278A (da) 1978-08-26

Similar Documents

Publication Publication Date Title
US4847301A (en) Methods of use of α-(aminoalkyl)-arylacetic acid derivatives
EP0226516B1 (de) Amidderivate und antiallergische Mittel, die sie enthalten
CA1096382A (en) PROCESSES FOR THE PREPARATION OF NEW ( ,-)-CIS-.alpha.- ¬3-(2,6-DIMETHYL-1-PIPERIDINYL)PROPYL|-.alpha.-PHENYL- 2-PYRIDINEMETHANOL COMPOUNDS
US4430335A (en) Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
US4028366A (en) 2-Naphthyl-lower-alkanoylamines
JPH089580B2 (ja) アミノアルコ−ル、その製造法およびその用途
US4112103A (en) Antiarrhythmic (+,-)-cis-α-[3-(2,6-dimethyl-1-piperidinyl)propyl]-α-phenyl-2-pyridinemethanols
US4005093A (en) 2-Naphthyl-lower-alkylamines
US4272533A (en) N-Phenylindoline derivatives, and pharmaceutical compositions containing them
US4375471A (en) 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines
US3926988A (en) Substituted pyrazoles
US4096331A (en) 1-Substituted-3-aminoethoxypyrrolidines
US4783537A (en) α-(aminoalkyl)-arylacetic acid derivatives
GB2171997A (en) 4-Amino-6,7-dimethoxy-2-Piperazin-1-ylquinazoline derivatives
US4472414A (en) Spiro[indolo[1,7-ab][1,5]benzodiazepine-2,4'-piperidines]
US3891652A (en) Antianginal aryldecahydropyrrolo{8 3,4-f{9 quinolines
US4432991A (en) Therapeutically active 3-amino-1-phenyl(and substituted phenyl)-2-pyrazolines
US4008276A (en) Phenyl-lower-alkylamines
EP0011206B1 (de) 9,10-Dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thiophen-4,9-imine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
KR840000103B1 (ko) 1, 1'-비페닐-2-일 알킬아민 유도체의 제조방법
IE46410B1 (en) A-phenyl-2-pyridinemethanol compounds and method for their production
US4038273A (en) Piperidone intermediates useful in the preparation of aryldecahydropyrrolo [3,4-f]quinolines
US4250184A (en) Treatment of pain, fever, and inflammation with compositions containing piperidinobutan-and 3-buten-2-ones
AU603081B2 (en) Symmetrical O-substituted dioximes of benzo-fused beta- diketocycloalkylenes, the processes for their preparation and their application as drugs
US4748276A (en) Process for preparing N,N-bis(2-hydroxyethyl)benzylamine and N,N-bis(2-chloroethyl)benzylamine

Legal Events

Date Code Title Description
MKEX Expiry