CA1092105A - Pyrrolo(2,1-b) (3)benzazepines - Google Patents

Pyrrolo(2,1-b) (3)benzazepines

Info

Publication number
CA1092105A
CA1092105A CA256,080A CA256080A CA1092105A CA 1092105 A CA1092105 A CA 1092105A CA 256080 A CA256080 A CA 256080A CA 1092105 A CA1092105 A CA 1092105A
Authority
CA
Canada
Prior art keywords
pyrrolo
saturated
dihydro
unsaturated
benzazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA256,080A
Other languages
English (en)
French (fr)
Inventor
Joshua Rokach
Joseph G. Atkinson
Clarence S. Rooney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA1092105A publication Critical patent/CA1092105A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA256,080A 1975-07-02 1976-06-30 Pyrrolo(2,1-b) (3)benzazepines Expired CA1092105A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59243675A 1975-07-02 1975-07-02
US592,436 1975-07-02

Publications (1)

Publication Number Publication Date
CA1092105A true CA1092105A (en) 1980-12-23

Family

ID=24370639

Family Applications (1)

Application Number Title Priority Date Filing Date
CA256,080A Expired CA1092105A (en) 1975-07-02 1976-06-30 Pyrrolo(2,1-b) (3)benzazepines

Country Status (18)

Country Link
JP (1) JPS527996A (cs)
AU (1) AU499122B2 (cs)
BE (1) BE843678A (cs)
CA (1) CA1092105A (cs)
CH (5) CH626366A5 (cs)
CY (1) CY1091A (cs)
DE (2) DE2629877A1 (cs)
ES (1) ES449432A1 (cs)
FR (1) FR2315935A1 (cs)
GB (1) GB1499047A (cs)
GR (1) GR60851B (cs)
HK (1) HK60580A (cs)
HU (1) HU177866B (cs)
MY (1) MY8100227A (cs)
NL (1) NL188287C (cs)
PT (1) PT65295B (cs)
SE (1) SE424076B (cs)
ZA (1) ZA763990B (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
JPH0487401U (cs) * 1990-12-06 1992-07-29
US6271392B1 (en) 1994-10-07 2001-08-07 Rhone-Poulenc Inc. Intermediates useful for the synthesis of 1-arylpyrrole pesticides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3428677A (en) * 1962-09-24 1969-02-18 Merck & Co Inc Chemical compounds and methods of preparing same
US3499037A (en) * 1966-05-31 1970-03-03 Merck & Co Inc Preparation of trifluoromethyl substituted dibenzocycloheptenes

Also Published As

Publication number Publication date
NL7607347A (nl) 1977-01-04
MY8100227A (en) 1981-12-31
BE843678A (fr) 1977-01-03
JPH0132225B2 (cs) 1989-06-29
DE2661014A1 (cs) 1985-07-04
DE2629877C2 (cs) 1989-01-05
GB1499047A (en) 1978-01-25
HK60580A (en) 1980-11-07
DE2629877A1 (de) 1977-01-20
CY1091A (en) 1980-12-27
AU499122B2 (en) 1979-04-05
FR2315935B1 (cs) 1978-11-17
CH626893A5 (en) 1981-12-15
DE2661014C2 (cs) 1989-01-05
CH626617A5 (en) 1981-11-30
CH626618A5 (en) 1981-11-30
FR2315935A1 (fr) 1977-01-28
NL188287C (nl) 1992-05-18
HU177866B (en) 1982-01-28
JPS527996A (en) 1977-01-21
PT65295B (en) 1978-05-10
CH626366A5 (en) 1981-11-13
ZA763990B (en) 1978-02-22
GR60851B (en) 1978-08-31
NL188287B (nl) 1991-12-16
SE7607534L (sv) 1977-01-03
ES449432A1 (es) 1977-12-16
CH626616A5 (en) 1981-11-30
PT65295A (en) 1976-07-01
AU1548876A (en) 1978-01-05
SE424076B (sv) 1982-06-28

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Legal Events

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