CA1087093A - Vaccines based on a ribosome fraction combined with a saccharide fraction from bacteria - Google Patents
Vaccines based on a ribosome fraction combined with a saccharide fraction from bacteriaInfo
- Publication number
- CA1087093A CA1087093A CA284,028A CA284028A CA1087093A CA 1087093 A CA1087093 A CA 1087093A CA 284028 A CA284028 A CA 284028A CA 1087093 A CA1087093 A CA 1087093A
- Authority
- CA
- Canada
- Prior art keywords
- corynebacterium
- fraction
- serratia
- saccharide
- extracted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 34
- 150000001720 carbohydrates Chemical class 0.000 title claims abstract description 25
- 241000894006 Bacteria Species 0.000 title claims description 10
- 210000003705 ribosome Anatomy 0.000 claims abstract description 17
- 241000186216 Corynebacterium Species 0.000 claims abstract description 12
- 241000607720 Serratia Species 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 11
- 230000001580 bacterial effect Effects 0.000 claims abstract description 10
- 241000588748 Klebsiella Species 0.000 claims abstract description 4
- 244000052616 bacterial pathogen Species 0.000 claims abstract description 4
- 239000012528 membrane Substances 0.000 claims description 14
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 241001508000 Corynebacterium bovis Species 0.000 claims description 2
- 241000186245 Corynebacterium xerosis Species 0.000 claims description 2
- 241001464974 Cutibacterium avidum Species 0.000 claims description 2
- 241001464975 Cutibacterium granulosum Species 0.000 claims description 2
- 241000605986 Fusobacterium nucleatum Species 0.000 claims description 2
- 241001524188 Glutamicibacter nicotianae Species 0.000 claims description 2
- 241000187694 Rhodococcus fascians Species 0.000 claims description 2
- 241000607715 Serratia marcescens Species 0.000 claims description 2
- 241001622809 Serratia plymuthica Species 0.000 claims description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims description 2
- 241000193996 Streptococcus pyogenes Species 0.000 claims description 2
- 241000186064 Trueperella pyogenes Species 0.000 claims description 2
- 241000204063 Tsukamurella paurometabola Species 0.000 claims description 2
- 241000186309 Brevibacterium helvolum Species 0.000 claims 1
- 241001464978 Clavibacter insidiosus Species 0.000 claims 1
- 241000990232 Curtobacterium flaccumfaciens pv. flaccumfaciens Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241001534204 Klebsiella pneumoniae subsp. rhinoscleromatis Species 0.000 claims 1
- 241000158504 Rhodococcus hoagii Species 0.000 claims 1
- 241000866060 Terrabacter tumescens Species 0.000 claims 1
- 125000000837 carbohydrate group Chemical group 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 abstract description 4
- 230000002265 prevention Effects 0.000 abstract description 2
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 15
- 210000002966 serum Anatomy 0.000 description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 8
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 239000002671 adjuvant Substances 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 241000606856 Pasteurella multocida Species 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 229940090044 injection Drugs 0.000 description 3
- 238000013508 migration Methods 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 229940051027 pasteurella multocida Drugs 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 244000228957 Ferula foetida Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- -1 MgC12 Chemical compound 0.000 description 2
- 241000606860 Pasteurella Species 0.000 description 2
- 229960002319 barbital Drugs 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000007775 late Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000186046 Actinomyces Species 0.000 description 1
- 101100134298 Bacillus subtilis (strain 168) nucA gene Proteins 0.000 description 1
- 241000237074 Centris Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 201000008197 Laryngitis Diseases 0.000 description 1
- 241000283986 Lepus Species 0.000 description 1
- 241001293418 Mannheimia haemolytica Species 0.000 description 1
- 239000013614 RNA sample Substances 0.000 description 1
- 108091006629 SLC13A2 Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000009267 bronchiectasis Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229940096118 ella Drugs 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000727 fraction Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0266—Klebsiella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7624124A FR2360314A2 (fr) | 1976-08-06 | 1976-08-06 | Nouveaux vaccins perfectionnes a base de fractions ribosomales |
| FR7624124 | 1976-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1087093A true CA1087093A (en) | 1980-10-07 |
Family
ID=9176646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA284,028A Expired CA1087093A (en) | 1976-08-06 | 1977-08-04 | Vaccines based on a ribosome fraction combined with a saccharide fraction from bacteria |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5320418A (enrdf_load_stackoverflow) |
| AU (1) | AU511331B2 (enrdf_load_stackoverflow) |
| BE (1) | BE857014R (enrdf_load_stackoverflow) |
| CA (1) | CA1087093A (enrdf_load_stackoverflow) |
| DE (1) | DE2735411C2 (enrdf_load_stackoverflow) |
| ES (1) | ES461415A2 (enrdf_load_stackoverflow) |
| FR (1) | FR2360314A2 (enrdf_load_stackoverflow) |
| GB (1) | GB1590144A (enrdf_load_stackoverflow) |
| ZA (1) | ZA774733B (enrdf_load_stackoverflow) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980000412A1 (en) * | 1978-08-24 | 1980-03-20 | N Gilmour | Pasteurellosis vaccines |
| JPS55106066U (enrdf_load_stackoverflow) * | 1979-01-19 | 1980-07-24 | ||
| JPS639754Y2 (enrdf_load_stackoverflow) * | 1979-01-25 | 1988-03-23 | ||
| FR2471785A1 (fr) | 1979-12-21 | 1981-06-26 | Fabre Sa Pierre | Preparations immunostimulantes a base d'arn ribosomaux et procede de preparation des arn |
| FR2475900A1 (fr) * | 1980-02-20 | 1981-08-21 | Fabre Sa Pierre | Complexe vaccinal contenant un antigene specifique et vaccin le contenant |
| US4293545A (en) | 1980-03-31 | 1981-10-06 | Norden Laboratories, Inc. | Modified Pasteurella multocida bacteria vaccines |
| US4388299A (en) | 1980-03-31 | 1983-06-14 | Norden Laboratories, Inc. | Modified pasteurella bacteria and vaccines prepared therefrom |
| US4335106A (en) | 1980-03-31 | 1982-06-15 | Norden Laboratories Inc. | Processes for the growth of a modified Pasteurella multocida bacteria and preparation of a vaccine therefrom |
| US4328210A (en) | 1980-03-31 | 1982-05-04 | Norden Laboratories, Inc. | Modified Pasteurella bacteria and vaccines prepared therefrom |
| US4506017A (en) * | 1981-04-17 | 1985-03-19 | Norden Laboratories, Inc. | Modified Pasteurella haemolytica bacteria |
| US4559306A (en) * | 1981-04-17 | 1985-12-17 | Norden Laboratories, Inc. | Modified Pasteurella multocida bacteria |
| US4626430A (en) * | 1981-04-17 | 1986-12-02 | Norden Laboratories, Inc. | Processes for growth of modified Pasteurella haemolytica bacteria and preparation of a vaccine therefrom |
| JPS58191628A (ja) * | 1982-05-04 | 1983-11-08 | Aisin Seiki Co Ltd | 車輌ル−フパネル開閉装置 |
| JPS626614A (ja) * | 1985-07-03 | 1987-01-13 | 株式会社チノー | 温室の天窓制御装置 |
| JPS62104526A (ja) * | 1985-10-30 | 1987-05-15 | 株式会社チノー | 温室の制御装置 |
| FR2596064B1 (fr) * | 1986-03-18 | 1990-02-02 | Pf Medicament | Procedes industriels de fabrication de vaccins ribosomaux et vaccins ribosomaux obtenus |
| DE19703437A1 (de) * | 1997-01-30 | 1998-08-06 | Luitpold Pharma Gmbh | Gemische äußerer Membranen und/oder Zellwände von Bakterien zur oralen Immunisierung gegen Schleimhautinfektionen |
| GB2370839A (en) * | 2001-01-06 | 2002-07-10 | Benedikt Timmerman | Immunogenic complex useful for disease control |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51142528A (en) * | 1975-05-19 | 1976-12-08 | Fabre Sa Pierre | Production of vaccine based on antigenic libosome fractionation |
-
1976
- 1976-08-06 FR FR7624124A patent/FR2360314A2/fr active Granted
-
1977
- 1977-07-20 BE BE179522A patent/BE857014R/xx not_active IP Right Cessation
- 1977-07-28 GB GB31746/77A patent/GB1590144A/en not_active Expired
- 1977-08-02 AU AU27538/77A patent/AU511331B2/en not_active Expired
- 1977-08-04 CA CA284,028A patent/CA1087093A/en not_active Expired
- 1977-08-04 JP JP9304877A patent/JPS5320418A/ja active Pending
- 1977-08-05 ZA ZA00774733A patent/ZA774733B/xx unknown
- 1977-08-05 DE DE2735411A patent/DE2735411C2/de not_active Expired
- 1977-08-05 ES ES461415A patent/ES461415A2/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2735411A1 (de) | 1978-02-09 |
| BE857014R (fr) | 1978-01-20 |
| JPS5320418A (en) | 1978-02-24 |
| AU2753877A (en) | 1979-02-08 |
| ZA774733B (en) | 1978-07-26 |
| DE2735411C2 (de) | 1982-07-29 |
| AU511331B2 (en) | 1980-08-14 |
| FR2360314B2 (enrdf_load_stackoverflow) | 1980-04-25 |
| FR2360314A2 (fr) | 1978-03-03 |
| GB1590144A (en) | 1981-05-28 |
| ES461415A2 (es) | 1978-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |