CA1084414A - Curable silicone with calcium hydroxide for blood storage - Google Patents
Curable silicone with calcium hydroxide for blood storageInfo
- Publication number
- CA1084414A CA1084414A CA282,880A CA282880A CA1084414A CA 1084414 A CA1084414 A CA 1084414A CA 282880 A CA282880 A CA 282880A CA 1084414 A CA1084414 A CA 1084414A
- Authority
- CA
- Canada
- Prior art keywords
- blood
- silicone rubber
- storage
- bag
- curable silicone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 75
- 239000008280 blood Substances 0.000 title claims abstract description 75
- 238000003860 storage Methods 0.000 title claims abstract description 32
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 title claims abstract description 13
- 229910001861 calcium hydroxide Inorganic materials 0.000 title claims abstract description 13
- 239000000920 calcium hydroxide Substances 0.000 title claims abstract description 13
- 229920001296 polysiloxane Polymers 0.000 title description 2
- 229920002379 silicone rubber Polymers 0.000 claims abstract description 24
- 239000004945 silicone rubber Substances 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 16
- 235000011116 calcium hydroxide Nutrition 0.000 claims abstract description 12
- 238000013329 compounding Methods 0.000 claims description 3
- 239000002473 artificial blood Substances 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 abstract description 7
- 230000035899 viability Effects 0.000 abstract description 4
- 239000004033 plastic Substances 0.000 abstract description 2
- 239000011575 calcium Substances 0.000 description 8
- XOHUEYCVLUUEJJ-UHFFFAOYSA-N 2,3-Bisphosphoglyceric acid Chemical compound OP(=O)(O)OC(C(=O)O)COP(O)(O)=O XOHUEYCVLUUEJJ-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229920001971 elastomer Polymers 0.000 description 7
- 239000005060 rubber Substances 0.000 description 7
- 230000003442 weekly effect Effects 0.000 description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 5
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 5
- 230000002745 absorbent Effects 0.000 description 5
- 239000002250 absorbent Substances 0.000 description 5
- 229960001456 adenosine triphosphate Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000007850 degeneration Effects 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 229960000643 adenine Drugs 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- -1 hydrogen ions Chemical class 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 230000007257 malfunction Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002023 wood Substances 0.000 description 3
- IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 description 2
- 229930024421 Adenine Natural products 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102000005548 Hexokinase Human genes 0.000 description 2
- 108700040460 Hexokinases Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000034659 glycolysis Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- XOHUEYCVLUUEJJ-UHFFFAOYSA-I 2,3-Diphosphoglycerate Chemical compound [O-]P(=O)([O-])OC(C(=O)[O-])COP([O-])([O-])=O XOHUEYCVLUUEJJ-UHFFFAOYSA-I 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- LXJXRIRHZLFYRP-VKHMYHEASA-N D-glyceraldehyde 3-phosphate Chemical compound O=C[C@H](O)COP(O)(O)=O LXJXRIRHZLFYRP-VKHMYHEASA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000001105 Phosphofructokinases Human genes 0.000 description 1
- 108010069341 Phosphofructokinases Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000029219 regulation of pH Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Dentistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/712,106 US4082509A (en) | 1976-08-05 | 1976-08-05 | Method of storing blood and a blood storage bag therefor |
| US712,106 | 1976-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1084414A true CA1084414A (en) | 1980-08-26 |
Family
ID=24860776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA282,880A Expired CA1084414A (en) | 1976-08-05 | 1977-07-15 | Curable silicone with calcium hydroxide for blood storage |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US4082509A (enExample) |
| JP (1) | JPS5930684B2 (enExample) |
| CA (1) | CA1084414A (enExample) |
| DE (1) | DE2735453C3 (enExample) |
| FR (1) | FR2360248A1 (enExample) |
| GB (1) | GB1538378A (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4304672A (en) * | 1978-04-04 | 1981-12-08 | Sbr Lab, Inc. | Stored blood and liquid system pH control method and apparatus |
| JPS5560459A (en) * | 1978-10-26 | 1980-05-07 | Baxter Travenol Lab | Polymer that can coexist with blood and medical appliance manufactured from said polymer |
| US4267269A (en) * | 1980-02-05 | 1981-05-12 | Baxter Travenol Laboratories, Inc. | Red cell storage solution |
| US4455299A (en) * | 1981-11-20 | 1984-06-19 | Baxter Travenol Laboratories, Inc. | Storage of blood platelets |
| EP0120875A4 (en) * | 1982-09-27 | 1985-12-05 | Baxter Travenol Lab | METHOD AND CONTAINER FOR STORING BLOOD PLATES. |
| DE3582523D1 (de) * | 1984-07-16 | 1991-05-23 | Sumitomo Bakelite Co | Behaelter und verfahren zur aufbewahrung von blut. |
| JPS61112564A (ja) * | 1984-11-07 | 1986-05-30 | Brother Ind Ltd | 往復運動装置 |
| JPS6241374U (enExample) * | 1985-08-30 | 1987-03-12 | ||
| US4902287A (en) * | 1987-09-24 | 1990-02-20 | Miles Inc. | Sterilizable system for blood storage |
| US5147776A (en) * | 1990-02-26 | 1992-09-15 | University Of Iowa Research Foundation | Use of 2,5-anhydromannitol for control of pH during blood storage |
| DE69126861T2 (de) * | 1990-11-07 | 1998-02-26 | Baxter Int | Lösung zur aufbewahrung roter blutzellen |
| US7025877B1 (en) * | 1999-06-03 | 2006-04-11 | Baxter International Inc. | Processing set for processing and treating a biological fluid |
| US6364864B1 (en) | 1999-06-03 | 2002-04-02 | Baxter International Inc. | Plastic containers having inner pouches and methods for making such containers |
| US7445756B2 (en) * | 1999-06-03 | 2008-11-04 | Fenwal, Inc. | Fluid processing sets and organizers for the same |
| US6565802B1 (en) | 1999-06-03 | 2003-05-20 | Baxter International Inc. | Apparatus, systems and methods for processing and treating a biological fluid with light |
| US7068361B2 (en) * | 1999-06-03 | 2006-06-27 | Baxter International | Apparatus, systems and methods for processing and treating a biological fluid with light |
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US11864553B2 (en) | 2009-10-23 | 2024-01-09 | Fenwal, Inc. | Methods and systems for providing red blood cell products with reduced plasma |
| ES2959120T3 (es) | 2010-08-25 | 2024-02-20 | Hemanext Inc | Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento |
| EP3539381B1 (en) | 2010-11-05 | 2023-05-24 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US8375730B2 (en) * | 2011-01-28 | 2013-02-19 | Tcp Reliable, Inc. | Selecting packaging and coolant systems for shipment of biological products |
| WO2013023156A1 (en) | 2011-08-10 | 2013-02-14 | New Health Sciences, Inc. | Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device |
| EP2741605B1 (en) | 2011-08-12 | 2020-06-17 | Cytosorbents Corporation | Polymeric sorbent for removal of impurities from whole blood and blood products |
| CA2902061C (en) | 2013-02-28 | 2023-08-08 | New Health Sciences, Inc. | Gas depletion and gas addition devices for blood treatment |
| US20160219870A1 (en) * | 2013-09-17 | 2016-08-04 | Becton, Dickinson And Company | Stabilization of Blood pH During Sample Storage |
| WO2016145210A1 (en) | 2015-03-10 | 2016-09-15 | New Health Sciences, Inc. | Oxygen reduction disposable kits, devices and methods of use thereof |
| IL285359B2 (en) | 2015-04-23 | 2024-01-01 | Hemanext Inc | Anaerobic blood storage containers |
| PT3297641T (pt) | 2015-05-18 | 2025-10-09 | Hemanext Inc | Métodos de armazenamento de sangue total e respetivas composições |
| WO2017044856A1 (en) * | 2015-09-10 | 2017-03-16 | New Health Sciences, Inc | Reinforced gas permeable blood storage bags, and methods of preparation thereof |
| CN109195632A (zh) | 2016-05-27 | 2019-01-11 | 新健康科学股份有限公司 | 厌氧血液储存和病原体失活方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE25129E (en) | 1962-02-27 | Apparatus for collecting | ||
| GB459951A (en) * | 1935-06-18 | 1937-01-18 | John Stoddart Wilson | An improved process for the treatment and preservation of blood for medicinal purposes |
| US2301710A (en) * | 1939-04-01 | 1942-11-10 | Charles R Drew | Apparatus for preserving blood |
| DE1068862B (de) * | 1957-05-03 | 1959-11-12 | Penicillin-Gesellschaft Dauelsberg a Co., Göttingen | Verfahren zur Verlängerung der Haltbarkeit von Blutkonserven |
| US3221741A (en) * | 1962-06-18 | 1965-12-07 | Veen Harry H Le | Container for collecting and storing blood having anticoagulant means therein |
| US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
| US3291612A (en) * | 1963-12-02 | 1966-12-13 | Schneider Packing Company | Method for collecting and preserving blood |
| US3418209A (en) * | 1964-06-16 | 1968-12-24 | Cordis Corp | Red cell preservation |
| US3942529A (en) * | 1967-02-01 | 1976-03-09 | Investrop A.G. | Package and method for storing blood |
| US3579999A (en) * | 1968-08-08 | 1971-05-25 | Redeco | Method and apparatus for the preservation of biological substances |
| US3677022A (en) * | 1969-07-24 | 1972-07-18 | Redeco | Method for extending the useful storage period of biological substances such as blood |
| US3729947A (en) * | 1970-12-04 | 1973-05-01 | Alza Corp | Process for storing blood platelets |
| US3925153A (en) * | 1971-05-14 | 1975-12-09 | Experimentales Et Cliniques De | Composition for conservation of blood |
| US3846236A (en) * | 1971-10-22 | 1974-11-05 | Wisconsin Alumni Res Found | Method and apparatus for dialysis |
| US3874384A (en) * | 1971-11-01 | 1975-04-01 | American Hospital Supply Corp | Improved blood storage unit and method of storing blood |
-
1976
- 1976-08-05 US US05/712,106 patent/US4082509A/en not_active Expired - Lifetime
-
1977
- 1977-07-15 CA CA282,880A patent/CA1084414A/en not_active Expired
- 1977-08-03 GB GB32527/77A patent/GB1538378A/en not_active Expired
- 1977-08-04 FR FR7724024A patent/FR2360248A1/fr active Granted
- 1977-08-04 US US05/821,668 patent/US4162676A/en not_active Expired - Lifetime
- 1977-08-04 JP JP52093068A patent/JPS5930684B2/ja not_active Expired
- 1977-08-05 DE DE2735453A patent/DE2735453C3/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2735453B2 (de) | 1979-08-09 |
| JPS5930684B2 (ja) | 1984-07-28 |
| JPS5320683A (en) | 1978-02-25 |
| FR2360248B1 (enExample) | 1980-12-05 |
| US4162676A (en) | 1979-07-31 |
| DE2735453A1 (de) | 1978-02-09 |
| FR2360248A1 (fr) | 1978-03-03 |
| GB1538378A (en) | 1979-01-17 |
| DE2735453C3 (de) | 1980-04-10 |
| US4082509A (en) | 1978-04-04 |
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