CA1084395A - Method for sampling and fixing urinary metabolites on an immobilizing support and apparatus therefor - Google Patents
Method for sampling and fixing urinary metabolites on an immobilizing support and apparatus thereforInfo
- Publication number
- CA1084395A CA1084395A CA277,212A CA277212A CA1084395A CA 1084395 A CA1084395 A CA 1084395A CA 277212 A CA277212 A CA 277212A CA 1084395 A CA1084395 A CA 1084395A
- Authority
- CA
- Canada
- Prior art keywords
- strip
- washed
- paper
- dried
- resin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 64
- 239000002207 metabolite Substances 0.000 title claims abstract description 45
- 230000002485 urinary effect Effects 0.000 title claims abstract description 17
- 238000005070 sampling Methods 0.000 title claims abstract description 14
- 230000003100 immobilizing effect Effects 0.000 title abstract description 8
- 210000002700 urine Anatomy 0.000 claims abstract description 35
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims abstract description 21
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000741 silica gel Substances 0.000 claims abstract description 17
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 17
- 239000000126 substance Substances 0.000 claims abstract description 13
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000003456 ion exchange resin Substances 0.000 claims abstract description 6
- 229920003303 ion-exchange polymer Polymers 0.000 claims abstract description 6
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 230000029142 excretion Effects 0.000 claims abstract description 4
- 229940097043 glucuronic acid Drugs 0.000 claims abstract description 4
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 claims abstract description 3
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 58
- 239000011347 resin Substances 0.000 claims description 36
- 229920005989 resin Polymers 0.000 claims description 36
- 229940109239 creatinine Drugs 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- KPWDGTGXUYRARH-UHFFFAOYSA-N 2,2,2-trichloroethanol Chemical compound OCC(Cl)(Cl)Cl KPWDGTGXUYRARH-UHFFFAOYSA-N 0.000 claims description 21
- 229960004319 trichloroacetic acid Drugs 0.000 claims description 20
- 238000011088 calibration curve Methods 0.000 claims description 18
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 16
- 230000003287 optical effect Effects 0.000 claims description 15
- 239000004793 Polystyrene Substances 0.000 claims description 14
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 claims description 14
- 229920002223 polystyrene Polymers 0.000 claims description 13
- 125000000524 functional group Chemical group 0.000 claims description 10
- 238000004458 analytical method Methods 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 9
- 238000005259 measurement Methods 0.000 claims description 9
- BGNGWHSBYQYVRX-UHFFFAOYSA-N 4-(dimethylamino)benzaldehyde Chemical compound CN(C)C1=CC=C(C=O)C=C1 BGNGWHSBYQYVRX-UHFFFAOYSA-N 0.000 claims description 6
- 239000008188 pellet Substances 0.000 claims description 6
- 239000002609 medium Substances 0.000 claims description 5
- 239000012454 non-polar solvent Substances 0.000 claims description 5
- 238000012360 testing method Methods 0.000 claims description 5
- XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 4
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims description 3
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 238000004040 coloring Methods 0.000 claims description 3
- 230000006872 improvement Effects 0.000 claims description 3
- ZVUUCUFDAHKLKT-UHFFFAOYSA-M sodium;2,4,6-trinitrophenolate Chemical compound [Na+].[O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O ZVUUCUFDAHKLKT-UHFFFAOYSA-M 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 230000018044 dehydration Effects 0.000 claims description 2
- 238000006297 dehydration reaction Methods 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 229960001866 silicon dioxide Drugs 0.000 claims 7
- 239000013013 elastic material Substances 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 17
- 238000006243 chemical reaction Methods 0.000 description 11
- 239000011734 sodium Substances 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000005406 washing Methods 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
- 239000004202 carbamide Substances 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 210000002356 skeleton Anatomy 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- 238000003795 desorption Methods 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 4
- 239000008351 acetate buffer Substances 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000003517 fume Substances 0.000 description 3
- SZIFAVKTNFCBPC-UHFFFAOYSA-N 2-chloroethanol Chemical compound OCCCl SZIFAVKTNFCBPC-UHFFFAOYSA-N 0.000 description 2
- 244000118350 Andrographis paniculata Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000581444 Clinidae Species 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- -1 NH40H Chemical class 0.000 description 1
- 229910017974 NH40H Inorganic materials 0.000 description 1
- 208000028571 Occupational disease Diseases 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- WIRUZQNBHNAMAB-UHFFFAOYSA-N benzene;cyclohexane Chemical compound C1CCCCC1.C1=CC=CC=C1 WIRUZQNBHNAMAB-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- QVLTXCYWHPZMCA-UHFFFAOYSA-N po4-po4 Chemical compound OP(O)(O)=O.OP(O)(O)=O QVLTXCYWHPZMCA-UHFFFAOYSA-N 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003233 pyrroles Chemical class 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229940116591 skeleton diagnostic radiopharmaceuticals Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/19—Halogen containing
- Y10T436/196666—Carbon containing compound [e.g., vinylchloride, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Surgery (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7612788A FR2349315A1 (fr) | 1976-04-29 | 1976-04-29 | Procede de fixation de metabolites urinaires sur un support adsorbant et dispositif pour la mise en oeuvre de ce procede |
| FR7612788 | 1976-04-29 | ||
| FR7709364 | 1977-03-29 | ||
| FR7709364A FR2385377A2 (fr) | 1976-04-29 | 1977-03-29 | Procede de fixation des metabolites urinaires sur un support adsorbant et dispositif pour la mise en oeuvre de ce procede |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1084395A true CA1084395A (en) | 1980-08-26 |
Family
ID=26219425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA277,212A Expired CA1084395A (en) | 1976-04-29 | 1977-04-28 | Method for sampling and fixing urinary metabolites on an immobilizing support and apparatus therefor |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4159193A (enExample) |
| JP (1) | JPS52148196A (enExample) |
| CA (1) | CA1084395A (enExample) |
| DE (1) | DE2719286C2 (enExample) |
| FR (1) | FR2385377A2 (enExample) |
| GB (1) | GB1553455A (enExample) |
| SE (1) | SE7704921L (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS202434B1 (en) * | 1979-01-09 | 1981-01-30 | Ivan Dolejsi | Method of detec ing the malign ulcers from the the urine samples |
| ES488577A0 (es) * | 1979-02-20 | 1981-02-16 | Hoechst Ag | Un sistema microcroma tografico perfeccionado para controlarla ingestion de medicamentos por parte de un paciente. |
| US4725406A (en) * | 1985-10-21 | 1988-02-16 | American Bionetics, Inc. | Apparatus and method for diagnostic analysis of biological fluids |
| US4849173A (en) * | 1987-07-24 | 1989-07-18 | Chang Mao Kuei | Excrement examination unit |
| US5283038A (en) * | 1990-12-18 | 1994-02-01 | Saliva Diagnostic Systems, Inc. | Fluid sampling and testing device |
| WO1997006428A1 (en) * | 1995-08-10 | 1997-02-20 | Poole Brent W | Handheld liquid test device |
| WO2000039579A1 (en) * | 1998-12-29 | 2000-07-06 | Flexsite Diagnostics, Inc. | Remote site urine collection device and method of use |
| US20060281188A1 (en) * | 2005-06-13 | 2006-12-14 | Cornell Research Foundation, Inc. | Ratiometric test strip and method |
| US9128168B2 (en) * | 2007-12-14 | 2015-09-08 | Cornell University | Method of determing excretion of sodium and other analytes |
| KR101080832B1 (ko) * | 2011-01-31 | 2011-11-07 | 전인수 | 변좌 내장식 소변 분석 시스템 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA928198A (en) * | 1968-07-15 | 1973-06-12 | Boehringer Mannheim G.M.B.H. | Storable blood and serum samples and a process for their preparation |
| IL33640A (en) * | 1969-01-16 | 1973-05-31 | Kabi Ab | Test strip packaged-unit |
| SE360179B (enExample) * | 1972-01-31 | 1973-09-17 | F Linder | |
| US3741727A (en) * | 1972-02-04 | 1973-06-26 | Us Army | Arsenic sampler |
| JPS5240239B2 (enExample) * | 1973-09-18 | 1977-10-11 | ||
| JPS50126297A (enExample) * | 1974-03-22 | 1975-10-03 | ||
| US4073693A (en) * | 1976-06-08 | 1978-02-14 | American Home Products Corporation | Apparatus and method for conducting a plurality of biological tests |
| US4066646A (en) * | 1976-12-23 | 1978-01-03 | General Electric Company | Diagnostic device and housing therefor |
-
1977
- 1977-03-29 FR FR7709364A patent/FR2385377A2/fr active Granted
- 1977-04-27 US US05/791,330 patent/US4159193A/en not_active Expired - Lifetime
- 1977-04-28 CA CA277,212A patent/CA1084395A/en not_active Expired
- 1977-04-28 SE SE7704921A patent/SE7704921L/ not_active Application Discontinuation
- 1977-04-28 GB GB17880/77A patent/GB1553455A/en not_active Expired
- 1977-04-29 DE DE2719286A patent/DE2719286C2/de not_active Expired
- 1977-04-30 JP JP5062377A patent/JPS52148196A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US4159193A (en) | 1979-06-26 |
| GB1553455A (en) | 1979-09-26 |
| DE2719286A1 (de) | 1977-11-17 |
| FR2385377A2 (fr) | 1978-10-27 |
| JPS52148196A (en) | 1977-12-09 |
| SE7704921L (sv) | 1977-10-30 |
| DE2719286C2 (de) | 1982-10-07 |
| FR2385377B2 (enExample) | 1982-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |