CA1059909A - Therapeutic system for administering scopolamine transdermally - Google Patents
Therapeutic system for administering scopolamine transdermallyInfo
- Publication number
- CA1059909A CA1059909A CA245,106A CA245106A CA1059909A CA 1059909 A CA1059909 A CA 1059909A CA 245106 A CA245106 A CA 245106A CA 1059909 A CA1059909 A CA 1059909A
- Authority
- CA
- Canada
- Prior art keywords
- lamina
- scopolamine
- bandage
- polyisobutene
- therapeutic system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960002646 scopolamine Drugs 0.000 title claims abstract description 60
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 title claims abstract description 58
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 title claims abstract description 58
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 title claims abstract description 58
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 title claims abstract description 58
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 19
- 239000012982 microporous membrane Substances 0.000 claims abstract description 9
- 206010028813 Nausea Diseases 0.000 claims abstract description 6
- 230000008693 nausea Effects 0.000 claims abstract description 6
- 206010047700 Vomiting Diseases 0.000 claims abstract description 4
- 229920002367 Polyisobutene Polymers 0.000 claims description 25
- 239000002480 mineral oil Substances 0.000 claims description 19
- 235000010446 mineral oil Nutrition 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 239000012528 membrane Substances 0.000 claims description 16
- -1 polypropylene Polymers 0.000 claims description 11
- 239000011248 coating agent Substances 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 9
- 239000004821 Contact adhesive Substances 0.000 claims description 8
- 238000005266 casting Methods 0.000 claims description 8
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 229920001155 polypropylene Polymers 0.000 claims description 5
- 238000009792 diffusion process Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000010030 laminating Methods 0.000 claims description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 2
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 239000010410 layer Substances 0.000 abstract description 25
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 4
- 239000011707 mineral Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 230000001681 protective effect Effects 0.000 abstract description 2
- 239000012790 adhesive layer Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 29
- 229940042472 mineral oil Drugs 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 10
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- 239000003921 oil Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000001166 anti-perspirative effect Effects 0.000 description 3
- 239000003213 antiperspirant Substances 0.000 description 3
- 229960001701 chloroform Drugs 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000812 cholinergic antagonist Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 229940116335 lauramide Drugs 0.000 description 2
- ILRSCQWREDREME-UHFFFAOYSA-N lauric acid amide propyl betaine Natural products CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- WTEVQBCEXWBHNA-YFHOEESVSA-N neral Chemical compound CC(C)=CCC\C(C)=C/C=O WTEVQBCEXWBHNA-YFHOEESVSA-N 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000000807 solvent casting Methods 0.000 description 2
- 230000036325 urinary excretion Effects 0.000 description 2
- MBEVSMZJMIQVBG-UHFFFAOYSA-N 2-(hydroxymethyl)guanidine Chemical compound NC(N)=NCO MBEVSMZJMIQVBG-UHFFFAOYSA-N 0.000 description 1
- 241001263092 Alchornea latifolia Species 0.000 description 1
- 241001167018 Aroa Species 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 241000761557 Lamina Species 0.000 description 1
- 101100238304 Mus musculus Morc1 gene Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 239000002579 antinauseant Substances 0.000 description 1
- 229940127248 antinauseant drug Drugs 0.000 description 1
- 210000001099 axilla Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N citral A Natural products CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- CCAFPWNGIUBUSD-UHFFFAOYSA-N diethyl sulfoxide Chemical compound CCS(=O)CC CCAFPWNGIUBUSD-UHFFFAOYSA-N 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 230000002445 parasympatholytic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000009117 preventive therapy Methods 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000005475 siliconizing Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/726—Permeability to liquids, absorption
- B32B2307/7265—Non-permeable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2323/00—Polyalkenes
- B32B2323/10—Polypropylene
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2367/00—Polyesters, e.g. PET, i.e. polyethylene terephthalate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2556/00—Patches, e.g. medical patches, repair patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54750475A | 1975-02-06 | 1975-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1059909A true CA1059909A (en) | 1979-08-07 |
Family
ID=24184910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA245,106A Expired CA1059909A (en) | 1975-02-06 | 1976-02-05 | Therapeutic system for administering scopolamine transdermally |
Country Status (17)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD337033S (en) | 1991-07-24 | 1993-07-06 | Deville | Pruning shears |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5621589Y2 (enrdf_load_html_response) * | 1977-05-30 | 1981-05-21 | ||
| US4201211A (en) * | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| JPS5843368B2 (ja) * | 1980-10-30 | 1983-09-27 | 日東電工株式会社 | 消炎鎮痛貼付剤 |
| JPS5942314A (ja) * | 1982-08-31 | 1984-03-08 | Nitto Electric Ind Co Ltd | 外用部材 |
| JPS5984816A (ja) * | 1982-11-08 | 1984-05-16 | Sekisui Chem Co Ltd | 薬剤徐放性製剤 |
| IE54286B1 (en) * | 1983-01-18 | 1989-08-16 | Elan Corp Plc | Drug delivery device |
| JPS6016916A (ja) * | 1983-07-08 | 1985-01-28 | Nitto Electric Ind Co Ltd | 生物活性物質含有基剤及び該基剤の製法 |
| DE3347277A1 (de) * | 1983-12-28 | 1985-07-11 | Bayer Ag, 5090 Leverkusen | Wirkstoffabgabesysteme |
| DE3423293C2 (de) * | 1984-06-23 | 1995-08-24 | Lohmann Therapie Syst Lts | Selbstklebendes Pflaster |
| DE3423328A1 (de) * | 1984-06-23 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | Selbstklebendes pflaster |
| US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
| IL72684A (en) * | 1984-08-14 | 1989-02-28 | Israel State | Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs |
| US4532244A (en) * | 1984-09-06 | 1985-07-30 | Innes Margaret N | Method of treating migraine headaches |
| EP0249475A3 (en) * | 1986-06-13 | 1989-10-11 | Alza Corporation | Delayed percutaneous delivery |
| FR2599976A1 (fr) * | 1986-06-16 | 1987-12-18 | Michel Pistor | Dispositif therapeutique, portable, totalement autonome, transdermique, pourvu d'au moins un organe formant aiguille ou pointe franchissant la barriere cutanee |
| GB8700150D0 (en) * | 1987-01-06 | 1987-02-11 | Martin I F | Wound dressings |
| CH674618A5 (enrdf_load_html_response) | 1987-04-02 | 1990-06-29 | Ciba Geigy Ag | |
| GB2212063A (en) * | 1987-11-12 | 1989-07-19 | Original Norfolk Trading Co Lt | Application of chemicals such as systemic herbicides and insecticides |
| FR2623718B1 (fr) * | 1987-11-27 | 1994-04-15 | Fabre Medicament Pierre | Dispositif therapeutique transdermique et son procede de preparation |
| DE3823395A1 (de) * | 1988-07-09 | 1990-03-15 | Holzapfel Boeving Partner Werb | Mit einem wirkstoff getraenktes tuch |
| DE4342174C1 (de) * | 1993-12-10 | 1995-05-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3767786A (en) * | 1961-04-20 | 1973-10-23 | Procter & Gamble | Inhibiting perspiration with scopolamine esters |
| NL6902314A (enrdf_load_html_response) * | 1969-02-13 | 1970-08-17 | ||
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| DE2012775C3 (de) * | 1970-03-18 | 1973-10-04 | V.P. Variopharm Gmbh Herstellung Und Vertrieb Pharmazeutischer, Kosmetischer Und Chemischer Erzeugnisse, 6656 Einoed | Salbenfohe und Verfahren zu ihrer Herstellung |
-
1976
- 1976-01-01 AR AR261972A patent/AR207805A1/es active
- 1976-01-02 GB GB101/76A patent/GB1511121A/en not_active Expired
- 1976-01-14 IL IL48840A patent/IL48840A/xx unknown
- 1976-01-15 ZA ZA234A patent/ZA76234B/xx unknown
- 1976-01-22 ES ES444552A patent/ES444552A1/es not_active Expired
- 1976-01-30 AU AU10678/76A patent/AU497383B2/en not_active Expired
- 1976-01-30 AT AT65676A patent/AT344326B/de not_active IP Right Cessation
- 1976-02-04 SE SE7601204A patent/SE424957B/xx not_active IP Right Cessation
- 1976-02-05 IT IT67264/76A patent/IT1057132B/it active Protection Beyond IP Right Term
- 1976-02-05 DK DK47676A patent/DK145284C/da active
- 1976-02-05 JP JP51011838A patent/JPS6049601B2/ja not_active Expired
- 1976-02-05 CH CH142376A patent/CH624848A5/de active Protection Beyond IP Right Term
- 1976-02-05 CA CA245,106A patent/CA1059909A/en not_active Expired
- 1976-02-05 FR FR7603167A patent/FR2299853A1/fr active Granted
- 1976-02-05 BE BE164114A patent/BE838295A/xx not_active IP Right Cessation
- 1976-02-06 DE DE2604718A patent/DE2604718C2/de not_active Expired
- 1976-02-06 NL NLAANVRAGE7601248,A patent/NL187379C/xx not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD337033S (en) | 1991-07-24 | 1993-07-06 | Deville | Pruning shears |
Also Published As
| Publication number | Publication date |
|---|---|
| AU497383B2 (en) | 1978-12-14 |
| CH624848A5 (en) | 1981-08-31 |
| FR2299853B1 (enrdf_load_html_response) | 1978-08-18 |
| ES444552A1 (es) | 1977-08-16 |
| AU1067876A (en) | 1977-08-04 |
| DK145284B (da) | 1982-10-25 |
| IT1057132B (it) | 1982-03-10 |
| ZA76234B (en) | 1977-01-26 |
| DK145284C (da) | 1983-03-21 |
| DK47676A (da) | 1976-08-07 |
| AR207805A1 (es) | 1976-10-29 |
| JPS51104021A (enrdf_load_html_response) | 1976-09-14 |
| IL48840A0 (en) | 1976-03-31 |
| AT344326B (de) | 1978-07-10 |
| BE838295A (fr) | 1976-05-28 |
| ATA65676A (de) | 1977-11-15 |
| NL187379B (nl) | 1991-04-16 |
| DE2604718A1 (de) | 1976-08-19 |
| SE7601204L (sv) | 1976-08-09 |
| NL187379C (nl) | 1991-09-16 |
| NL7601248A (nl) | 1976-08-10 |
| DE2604718C2 (de) | 1987-03-05 |
| GB1511121A (en) | 1978-05-17 |
| SE424957B (sv) | 1982-08-23 |
| JPS6049601B2 (ja) | 1985-11-02 |
| IL48840A (en) | 1978-01-31 |
| FR2299853A1 (fr) | 1976-09-03 |
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