CA1047923A - Method for producing a gamma-globulin solution suitable for intravenous application - Google Patents
Method for producing a gamma-globulin solution suitable for intravenous applicationInfo
- Publication number
- CA1047923A CA1047923A CA260,555A CA260555A CA1047923A CA 1047923 A CA1047923 A CA 1047923A CA 260555 A CA260555 A CA 260555A CA 1047923 A CA1047923 A CA 1047923A
- Authority
- CA
- Canada
- Prior art keywords
- gamma
- globulin
- acid ethyl
- solution
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010074605 gamma-Globulins Proteins 0.000 title claims abstract description 16
- 238000001990 intravenous administration Methods 0.000 title claims description 5
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002253 acid Substances 0.000 claims abstract description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000000243 solution Substances 0.000 claims abstract description 11
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 238000000502 dialysis Methods 0.000 claims abstract description 10
- 125000004494 ethyl ester group Chemical group 0.000 claims abstract description 8
- 238000011146 sterile filtration Methods 0.000 claims abstract description 7
- WASQWSOJHCZDFK-UHFFFAOYSA-N diketene Chemical compound C=C1CC(=O)O1 WASQWSOJHCZDFK-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- MEVHTHLQPUQANE-UHFFFAOYSA-N aziridine-2,3-dione Chemical compound O=C1NC1=O MEVHTHLQPUQANE-UHFFFAOYSA-N 0.000 claims abstract description 4
- FSSPGSAQUIYDCN-UHFFFAOYSA-N 1,3-Propane sultone Chemical compound O=S1(=O)CCCO1 FSSPGSAQUIYDCN-UHFFFAOYSA-N 0.000 claims abstract 3
- 238000010253 intravenous injection Methods 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- -1 ester hydrochloride Chemical class 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 description 7
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229960000380 propiolactone Drugs 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000002152 alkylating effect Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- HLCHESOMJVGDSJ-UHFFFAOYSA-N thiq Chemical compound C1=CC(Cl)=CC=C1CC(C(=O)N1CCC(CN2N=CN=C2)(CC1)C1CCCCC1)NC(=O)C1NCC2=CC=CC=C2C1 HLCHESOMJVGDSJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752539800 DE2539800C3 (de) | 1975-09-06 | 1975-09-06 | Verfahren zur Herstellung einer für die intravenöse Anwendung geeigneten Gammaglobulinlösung |
| DE19762614503 DE2614503A1 (de) | 1976-04-03 | 1976-04-03 | Verfahren zur herstellung einer fuer die intravenoese anwendung geeigneten gammaglobulinloesung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1047923A true CA1047923A (en) | 1979-02-06 |
Family
ID=25769365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA260,555A Expired CA1047923A (en) | 1975-09-06 | 1976-09-03 | Method for producing a gamma-globulin solution suitable for intravenous application |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4154819A (en, 2012) |
| JP (1) | JPS5234918A (en, 2012) |
| CA (1) | CA1047923A (en, 2012) |
| CH (1) | CH597864A5 (en, 2012) |
| FR (1) | FR2322611A2 (en, 2012) |
| GB (1) | GB1528259A (en, 2012) |
| NL (1) | NL7609832A (en, 2012) |
| SE (1) | SE7609785L (en, 2012) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK139056B (da) * | 1976-04-06 | 1978-12-11 | Nordisk Insulinlab | Fremgangsmåde til udvinding af immunoglobulin, der er egnet til intravenøs indgivelse. |
| DE2658334C3 (de) * | 1976-12-23 | 1987-05-07 | Behringwerke Ag, 3550 Marburg | Verfahren zum Herstellen von Immunglobulinpräparationen mit verminderter Komplementaktivität und ein diese enthaltendes Arzneimittel |
| US4296027A (en) * | 1977-08-31 | 1981-10-20 | The Regents Of The University Of Minnesota | Pure intravenous human and animal gamma globulins |
| DE2829769C3 (de) * | 1978-07-06 | 1982-10-14 | Gruner + Jahr Ag & Co, 2210 Itzehoe | Vorrichtung zum Heften mit metallischen Klammern |
| US4374763A (en) * | 1979-09-17 | 1983-02-22 | Morishita Pharmaceutical Co., Ltd. | Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof |
| US5219578A (en) * | 1991-02-25 | 1993-06-15 | Innovet, Inc. | Composition and method for immunostimulation in mammals |
| US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
| US8293242B2 (en) * | 2005-09-01 | 2012-10-23 | Plasma Technologies, Llc | Ultra-high yield of alpha-1-anti-trypsin |
| US7879332B2 (en) * | 2005-09-01 | 2011-02-01 | Plasma Technologies, Llc | Ultra-high yield intravenous immune globulin preparation |
| US20070049732A1 (en) * | 2005-09-01 | 2007-03-01 | Zurlo Eugene J | Ultra-high yield intravenous immune globulin preparation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3916026A (en) * | 1968-09-19 | 1975-10-28 | Biotest Serum Institut Gmbh | Method for the preparation of gamma-globulin suitable for intravenous use |
-
1976
- 1976-09-01 FR FR7626367A patent/FR2322611A2/fr active Granted
- 1976-09-01 JP JP51103762A patent/JPS5234918A/ja active Granted
- 1976-09-03 GB GB36594/76A patent/GB1528259A/en not_active Expired
- 1976-09-03 SE SE7609785A patent/SE7609785L/ not_active Application Discontinuation
- 1976-09-03 NL NL7609832A patent/NL7609832A/xx not_active Application Discontinuation
- 1976-09-03 CA CA260,555A patent/CA1047923A/en not_active Expired
- 1976-09-06 CH CH1130376A patent/CH597864A5/xx not_active IP Right Cessation
- 1976-09-07 US US05/721,130 patent/US4154819A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| SE7609785L (sv) | 1977-03-07 |
| US4154819A (en) | 1979-05-15 |
| GB1528259A (en) | 1978-10-11 |
| JPS5234918A (en) | 1977-03-17 |
| NL7609832A (nl) | 1977-03-08 |
| CH597864A5 (en, 2012) | 1978-04-14 |
| FR2322611B2 (en, 2012) | 1980-11-07 |
| FR2322611A2 (fr) | 1977-04-01 |
| JPS5516565B2 (en, 2012) | 1980-05-02 |
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