CA1042799A - Perfluorocyclocarbons as gas transport agents in animals - Google Patents
Perfluorocyclocarbons as gas transport agents in animalsInfo
- Publication number
- CA1042799A CA1042799A CA193,376A CA193376A CA1042799A CA 1042799 A CA1042799 A CA 1042799A CA 193376 A CA193376 A CA 193376A CA 1042799 A CA1042799 A CA 1042799A
- Authority
- CA
- Canada
- Prior art keywords
- perfluoro
- res
- perfluorocyclocarbon
- emulsion
- perfluorocyclocarbons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- LOQGSOTUHASIHI-UHFFFAOYSA-N perfluoro-1,3-dimethylcyclohexane Chemical compound FC(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(C(F)(F)F)C1(F)F LOQGSOTUHASIHI-UHFFFAOYSA-N 0.000 claims abstract description 6
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- 238000004321 preservation Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012950 reanalysis Methods 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000005245 right atrium Anatomy 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000002311 subsequent effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/102499—Blood gas standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US335454 US3911138B1 (en) | 1973-02-26 | 1973-02-26 | Artificial blood and method for supporting oxygen transport in animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1042799A true CA1042799A (en) | 1978-11-21 |
Family
ID=23311850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA193,376A Expired CA1042799A (en) | 1973-02-26 | 1974-02-25 | Perfluorocyclocarbons as gas transport agents in animals |
Country Status (7)
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3993581A (en) * | 1973-10-05 | 1976-11-23 | The Green Cross Corporation | Process for preparing stable oxygen transferable emulsion |
| DK155867C (da) * | 1974-12-09 | 1989-10-09 | Sun Ventures Inc | Emulsionspraeparat af perfluorerede forbindelser til anvendelse som syntetisk blod |
| IT1050731B (it) * | 1974-12-09 | 1981-03-20 | Childrens Hosp Medical Center | Composti perfluoropoliciclici per l impiego come sangue sintetico e ambiente di ferfusione |
| US4163734A (en) * | 1975-05-30 | 1979-08-07 | Radiometer A/S | Reference liquid for blood gas equipment |
| US4105798A (en) * | 1976-07-19 | 1978-08-08 | Sun Ventures, Inc. | Perfluoro polycyclic compounds for use as synthetic blood and perfusion media |
| US4186253A (en) * | 1978-10-10 | 1980-01-29 | The Green Cross Corporation | Perfusate for preserving organ to be transplanted and preserving method |
| US4289499A (en) * | 1978-10-13 | 1981-09-15 | Childrens Hospital Medical Center | Selecting perfluorocarbon compounds for synthetic blood |
| US4252827A (en) * | 1979-05-23 | 1981-02-24 | The Green Cross Corporation | Oxygen-transferable fluorocarbon emulsion |
| EP0031353B1 (en) * | 1979-06-25 | 1984-08-08 | Suntech, Inc. | Use of perfluorocarbon as burn treatment |
| US4402984A (en) * | 1980-07-03 | 1983-09-06 | Sun Tech, Inc. | Preparation of 1-hydropentadecafluoroadamantane and perfluoroadamantane |
| US4299728A (en) * | 1980-07-21 | 1981-11-10 | Instrumentation Laboratory Inc. | Blood gas control |
| US4369127A (en) * | 1980-07-21 | 1983-01-18 | Instrumentation Laboratory Inc. | Blood gas control |
| FR2515198A1 (fr) * | 1981-10-22 | 1983-04-29 | Centre Nat Rech Scient | Microemulsions aqueuses de fluorocarbures indefiniment stables a une temperature donnee, procede d'obtention et application a titre de transporteurs d'oxygene |
| US4569784A (en) * | 1980-11-17 | 1986-02-11 | Adamantech, Inc. | Preparation of a gel having gas transporting capability |
| US4879062A (en) * | 1981-10-20 | 1989-11-07 | Adamantech, Inc. | Preparation of a gel having gas transporting capability |
| CA1187882A (en) * | 1981-11-27 | 1985-05-28 | Kazumasa Yokoyama | Perfluoro compound and emulsion thereof |
| US4448188A (en) * | 1982-02-18 | 1984-05-15 | Laserscope, Inc. | Method for providing an oxygen bearing liquid to a blood vessel for the performance of a medical procedure |
| US4490351A (en) * | 1982-03-15 | 1984-12-25 | Children's Hospital Medical Center | Methods of treating disorders of an eye with liquid perfluorocarbons |
| US4452818A (en) * | 1982-03-19 | 1984-06-05 | Haidt Sterling J | Extraocular method of treating the eye with liquid perfluorocarbons |
| US4461717A (en) * | 1982-03-19 | 1984-07-24 | Sun Tech, Inc. | Stable gas-carrying compositions |
| US4453028A (en) * | 1982-03-29 | 1984-06-05 | Lagow Richard J | Perfluorinated compounds with cyclohexyl groups |
| USRE33451E (en) * | 1982-04-12 | 1990-11-20 | Children's Hospital Medical Center | Artificial blood and other gas transport agents |
| US4443480A (en) * | 1982-04-12 | 1984-04-17 | Children's Hospital Medical Center | Artificial blood and other gas transport agents |
| WO1984000686A1 (en) * | 1982-08-17 | 1984-03-01 | Sun Tech Inc | Perfluorocarbon emulsions and their preparation and use in therapy |
| JPS5939870A (ja) * | 1982-08-30 | 1984-03-05 | Green Cross Corp:The | フルオロカ−ボン乳化製剤 |
| JPS5946218A (ja) | 1982-09-09 | 1984-03-15 | Green Cross Corp:The | フルオロカ−ボン乳化製剤 |
| US4534978A (en) * | 1982-12-28 | 1985-08-13 | The Green Cross Corporation | Perfluorocycloamines |
| EP0121614B1 (en) * | 1983-03-30 | 1987-06-03 | Green Cross Corporation | Perfluorotricyclic amine compounds |
| US4530936A (en) * | 1983-07-08 | 1985-07-23 | Farmacon Research Corporation | Composition and method for inhibiting the absorption of nutritional elements from the upper intestinal tract |
| US4917930A (en) * | 1984-04-16 | 1990-04-17 | Adamantech, Inc. | Perfluoro compound dispersions containing reduced amounts of surfactant and process of preparation |
| GB8504916D0 (en) * | 1985-02-26 | 1985-03-27 | Isc Chemicals Ltd | Emulsions of perfluorocarbons in aqueous media |
| US4931472A (en) * | 1985-09-17 | 1990-06-05 | Biomed Technology, Inc. | Fluorinated triethylenediamine as an oxygen transport agent |
| US4680268A (en) * | 1985-09-18 | 1987-07-14 | Children's Hospital Medical Center | Implantable gas-containing biosensor and method for measuring an analyte such as glucose |
| US5514720A (en) * | 1986-07-09 | 1996-05-07 | Hemagen/Pfc | Stable emulsions of highly fluorinated organic compounds |
| US5684050A (en) * | 1986-01-24 | 1997-11-04 | Hemagen/Pfc | Stable emulsions of highly fluorinated organic compounds |
| US5536753A (en) * | 1986-01-24 | 1996-07-16 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center And Hemagen/Pfc | Stable perfluorocarbon and oil emulsions |
| US4722904A (en) * | 1986-12-18 | 1988-02-02 | Fisher Scientific Company | Thermodynamically-stable aqueous perfluorocarbon microemulsion useful as blood gas control or calibrator |
| WO1988005261A1 (en) * | 1987-01-16 | 1988-07-28 | Tops Systems, Inc. | Total organ perfusion system |
| US4956390A (en) * | 1987-08-25 | 1990-09-11 | Air Products And Chemicals, Inc. | Gas transport employing perfluorobutyldecalin |
| US5171755A (en) * | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
| US4975528A (en) * | 1989-04-07 | 1990-12-04 | Affinity Biotech, Inc. | Process for separation and concentration of apolipoproteins using perfluorocarbon emulsion |
| US5116599A (en) * | 1989-07-31 | 1992-05-26 | Johns Hopkins Univ. | Perfluoro-t-butyl-containing compounds for use in fluorine-19 nmr and/or mri |
| US5234680A (en) * | 1989-07-31 | 1993-08-10 | Johns Hopkins Univ. | Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI |
| US5562608A (en) * | 1989-08-28 | 1996-10-08 | Biopulmonics, Inc. | Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation |
| US5518731A (en) * | 1990-09-27 | 1996-05-21 | Allergan, Inc. | Nonaqueous fluorinated drug delivery vehicle suspensions |
| US6458376B1 (en) | 1990-09-27 | 2002-10-01 | Allergan, Inc. | Nonaqueous fluorinated drug delivery suspensions |
| US5173298A (en) * | 1990-09-27 | 1992-12-22 | Allergan, Inc. | Nonaqueous fluorinated drug delivery vehicle suspensions |
| US5304325A (en) * | 1991-11-13 | 1994-04-19 | Hemagen/Pfc | Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use |
| US5403575A (en) * | 1991-12-12 | 1995-04-04 | Hemagen/Pfc | Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them |
| US5336175A (en) * | 1992-10-29 | 1994-08-09 | Mames Robert N | Method for the treatment of retinal detachments |
| US5595687A (en) * | 1992-10-30 | 1997-01-21 | Thomas Jefferson University | Emulsion stability |
| US5420359A (en) * | 1992-12-11 | 1995-05-30 | Minnesota Mining And Manufacturing Company | Chlorofluoroether compositions and preparation thereof |
| US6794357B1 (en) * | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
| US5480914A (en) * | 1994-05-06 | 1996-01-02 | Allergan, Inc. | Nonaqueous thixotropic drug delivery suspensions and methods of their use |
| US5824703A (en) * | 1994-05-13 | 1998-10-20 | Synthetic Blood International, Inc. | Method of assisting normal breathing in a mammal having a lung disorder |
| US5674913A (en) * | 1994-05-13 | 1997-10-07 | Synthetic Blood International, Inc. | Method for assisting normal breathing in a mammal having a lung disorder |
| US5476974A (en) * | 1994-05-20 | 1995-12-19 | Minnesota Mining And Manufacturing Company | Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application |
| US5658962A (en) * | 1994-05-20 | 1997-08-19 | Minnesota Mining And Manufacturing Company | Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application |
| US5502094A (en) * | 1994-05-20 | 1996-03-26 | Minnesota Mining And Manufacturing Company | Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use |
| US6165976A (en) | 1994-06-23 | 2000-12-26 | Astra Aktiebolag | Therapeutic preparation for inhalation |
| US5770585A (en) * | 1995-05-08 | 1998-06-23 | Kaufman; Robert J. | Homogeneous water-in-perfluorochemical stable liquid dispersion for administration of a drug to the lung of an animal |
| US5840767A (en) * | 1995-12-01 | 1998-11-24 | Synthetic Blood International, Inc. | Perfluorocarbons for biological gas exchange and method |
| US8137684B2 (en) | 1996-10-01 | 2012-03-20 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US6026815A (en) * | 1996-10-10 | 2000-02-22 | Gholam A. Peyman | Radiopaque liquid as radiation blocking agent |
| US6167887B1 (en) | 1997-11-21 | 2001-01-02 | Synthetic Blood International, Inc. | Selected C-10 perfluorinated hydrocarbons for liquid ventilation and artificial blood |
| DE19861012A1 (de) | 1998-03-18 | 1999-09-30 | Pharm Pur Gmbh | Behandlungsmittel für die Ophthalmologie |
| US7008535B1 (en) | 2000-08-04 | 2006-03-07 | Wayne State University | Apparatus for oxygenating wastewater |
| WO2007134304A1 (en) * | 2006-05-15 | 2007-11-22 | Virginia Commonwealth University | Methods and compositions for controlled and sustained production and delivery of peroxides |
| US20090202617A1 (en) * | 2008-02-13 | 2009-08-13 | Ward Kevin R | Gas based wound and tissue therapeutics |
| WO2010008594A1 (en) * | 2008-07-18 | 2010-01-21 | Oxygen Biotherapeutics, Inc. | Method of treating traumatic brain injury |
| US20100055067A1 (en) * | 2008-08-26 | 2010-03-04 | Snu R&Db Foundation | Perfluorocarbon conjugate as a blood substitute |
| US8343515B2 (en) * | 2008-11-25 | 2013-01-01 | Oxygen Biotherapeutics, Inc. | Perfluorocarbon gel formulations |
| US20100144597A1 (en) * | 2008-12-10 | 2010-06-10 | Ward Kevin R | Novel combinatorial approaches to enhancing oxygen transport to tissues |
| WO2011014247A1 (en) * | 2009-07-28 | 2011-02-03 | Oxygen Biotherapeutics, Inc. | Method to increase oxygen in male and female sexual organs through the topical use of perfluorocarbons |
| EP2547201A1 (en) * | 2010-03-19 | 2013-01-23 | Oxygen Biotherapeutics, Inc. | Perfluorocarbon eye cream formulations |
| US8513309B2 (en) | 2010-10-01 | 2013-08-20 | Oxygen Biotherapeutics, Inc. | Perfluorocarbons for use in treating pruritus |
| JP2018525489A (ja) | 2015-08-11 | 2018-09-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 材料複合体 |
| KR102384708B1 (ko) * | 2020-06-19 | 2022-04-11 | 대한민국 | 혈흔형태분석용 인공혈액 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH604490A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1970-09-05 | 1978-09-15 | Green Cross Corp | |
| GB1343870A (en) * | 1971-05-19 | 1974-01-16 | Green Cross Corp | Emulsions and the preparation thereof |
| US3768585A (en) * | 1971-08-17 | 1973-10-30 | Eaton Corp | Steering axle |
| US3760090A (en) * | 1971-08-19 | 1973-09-18 | Globe Union Inc | Electronic circuit package and method for making same |
| JPS50890B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1971-09-13 | 1975-01-13 | ||
| JPS4861616A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1971-12-06 | 1973-08-29 | ||
| JPS5443568B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-04-05 | 1979-12-20 |
-
1973
- 1973-02-26 US US335454 patent/US3911138B1/en not_active Expired - Lifetime
-
1974
- 1974-02-25 JP JP49022260A patent/JPS5058215A/ja active Pending
- 1974-02-25 DK DK099174A patent/DK152643C/da not_active IP Right Cessation
- 1974-02-25 FR FR7406360A patent/FR2218903B1/fr not_active Expired
- 1974-02-25 CA CA193,376A patent/CA1042799A/en not_active Expired
- 1974-02-25 DE DE2409598A patent/DE2409598A1/de not_active Ceased
- 1974-02-26 GB GB869674A patent/GB1467172A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3911138B1 (en) | 1996-10-29 |
| DK152643B (da) | 1988-04-05 |
| JPS5058215A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-05-21 |
| US3911138A (en) | 1975-10-07 |
| GB1467172A (en) | 1977-03-16 |
| FR2218903B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-11-04 |
| DE2409598A1 (de) | 1974-10-10 |
| FR2218903A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-09-20 |
| DK152643C (da) | 1988-08-15 |
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