CA1041903A - Coagulation et separation des phases du sang - Google Patents
Coagulation et separation des phases du sangInfo
- Publication number
- CA1041903A CA1041903A CA231,655A CA231655A CA1041903A CA 1041903 A CA1041903 A CA 1041903A CA 231655 A CA231655 A CA 231655A CA 1041903 A CA1041903 A CA 1041903A
- Authority
- CA
- Canada
- Prior art keywords
- blood
- particles
- activating
- vessel
- density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000926 separation method Methods 0.000 title claims abstract description 16
- 230000023555 blood coagulation Effects 0.000 title abstract description 4
- 210000004369 blood Anatomy 0.000 claims abstract description 112
- 239000008280 blood Substances 0.000 claims abstract description 112
- 239000002245 particle Substances 0.000 claims abstract description 81
- 238000000034 method Methods 0.000 claims abstract description 33
- 210000002966 serum Anatomy 0.000 claims abstract description 31
- 238000005345 coagulation Methods 0.000 claims abstract description 16
- 230000015271 coagulation Effects 0.000 claims abstract description 16
- 238000013019 agitation Methods 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims description 21
- 239000011521 glass Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 15
- 239000003114 blood coagulation factor Substances 0.000 claims description 13
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims description 12
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims description 12
- 238000005119 centrifugation Methods 0.000 claims description 12
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 230000001413 cellular effect Effects 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 230000003213 activating effect Effects 0.000 claims description 6
- 239000013049 sediment Substances 0.000 claims description 6
- 239000005995 Aluminium silicate Substances 0.000 claims description 5
- 235000012211 aluminium silicate Nutrition 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 239000000440 bentonite Substances 0.000 claims description 4
- 229910000278 bentonite Inorganic materials 0.000 claims description 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 206010001497 Agitation Diseases 0.000 description 11
- 102000009123 Fibrin Human genes 0.000 description 11
- 108010073385 Fibrin Proteins 0.000 description 11
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 11
- 229950003499 fibrin Drugs 0.000 description 11
- 238000001994 activation Methods 0.000 description 7
- 230000004913 activation Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 102000008946 Fibrinogen Human genes 0.000 description 3
- 108010049003 Fibrinogen Proteins 0.000 description 3
- 229940012952 fibrinogen Drugs 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 238000007864 suspending Methods 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000005297 pyrex Substances 0.000 description 2
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 102000000429 Factor XII Human genes 0.000 description 1
- 108010080865 Factor XII Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102000002262 Thromboplastin Human genes 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 230000000332 continued effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000009428 plumbing Methods 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52174074A | 1974-11-07 | 1974-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1041903A true CA1041903A (fr) | 1978-11-07 |
Family
ID=24077937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA231,655A Expired CA1041903A (fr) | 1974-11-07 | 1975-07-16 | Coagulation et separation des phases du sang |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5169264A (fr) |
| CA (1) | CA1041903A (fr) |
| DE (2) | DE2560565C2 (fr) |
| FR (1) | FR2290665A1 (fr) |
| GB (1) | GB1513806A (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4190535A (en) * | 1978-02-27 | 1980-02-26 | Corning Glass Works | Means for separating lymphocytes and monocytes from anticoagulated blood |
| US4310430A (en) * | 1979-09-11 | 1982-01-12 | Terumo Corporation | α-Olefin-dialkylmaleate-based liquid separating agent |
| JPS5644056A (en) * | 1979-09-17 | 1981-04-23 | Sekisui Chem Co Ltd | Composition for separating serum |
| NO146616C (no) * | 1979-10-04 | 1982-11-03 | Ken Heimreid | Fremgangsmaate og anordning ved preparering til undersoekelse av ukoagulert blod. |
| DE3029579C2 (de) * | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| JPS57146162A (en) * | 1981-03-05 | 1982-09-09 | Michizo Yamano | Method for obtaining serum by filtering blood |
| JPS57159562A (en) * | 1981-03-24 | 1982-10-01 | Sekisui Chem Co Ltd | Separation of serum |
| JPS57187658A (en) * | 1981-05-13 | 1982-11-18 | Sekisui Chem Co Ltd | Container for blood inspection |
| JPS5842970A (ja) * | 1981-09-07 | 1983-03-12 | Sekisui Chem Co Ltd | 血液検査用容器 |
| JPS58105064A (ja) * | 1981-12-17 | 1983-06-22 | Sekisui Chem Co Ltd | 血液凝固促進剤 |
| JPS58144746A (ja) * | 1982-02-23 | 1983-08-29 | Sekisui Chem Co Ltd | 血清と血餅との分離方法 |
| JPS58196457A (ja) * | 1982-05-11 | 1983-11-15 | Sekisui Chem Co Ltd | 血清と血餅との分離方法 |
| DE3343887A1 (de) * | 1983-12-05 | 1985-06-13 | Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht | Anordnung zur plazierung eines trenngels zwischen zwei in einem probenroehrchen befindlichen phasen |
| DE3637421C1 (de) * | 1986-11-03 | 1987-10-29 | Nerbe Plus Ges Fuer Medizinisc | Reaktionsgefaess fuer die Blutgerinnungsreaktion |
| US4883764A (en) * | 1987-07-20 | 1989-11-28 | Kloepfer Mary A | Blood test strip |
| US5326535A (en) * | 1993-04-30 | 1994-07-05 | Becton, Dickinson And Company | Tube having unitary blood coagulation activator and method for its preparation |
| US5378431A (en) * | 1993-06-14 | 1995-01-03 | Becton, Dickinson And Company | Dual pathway clotting enhancer for blood collection tube |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4935985B2 (fr) * | 1972-02-26 | 1974-09-27 | ||
| JPS542120A (en) * | 1977-06-07 | 1979-01-09 | Ricoh Co Ltd | Brake device of focal plane shutter |
-
1975
- 1975-07-16 CA CA231,655A patent/CA1041903A/fr not_active Expired
- 1975-10-09 GB GB4140775A patent/GB1513806A/en not_active Expired
- 1975-10-11 DE DE19752560565 patent/DE2560565C2/de not_active Expired
- 1975-10-11 DE DE19752545749 patent/DE2545749A1/de not_active Ceased
- 1975-11-05 JP JP13221975A patent/JPS5169264A/ja active Pending
- 1975-11-06 FR FR7533951A patent/FR2290665A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB1513806A (en) | 1978-06-07 |
| JPS5169264A (en) | 1976-06-15 |
| FR2290665A1 (fr) | 1976-06-04 |
| DE2545749A1 (de) | 1976-05-13 |
| DE2560565C2 (de) | 1985-12-12 |
| FR2290665B1 (fr) | 1979-07-20 |
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