CA1039270A - 3-thio-substituted cephalosporin antibiotics - Google Patents

3-thio-substituted cephalosporin antibiotics

Info

Publication number
CA1039270A
CA1039270A CA237,876A CA237876A CA1039270A CA 1039270 A CA1039270 A CA 1039270A CA 237876 A CA237876 A CA 237876A CA 1039270 A CA1039270 A CA 1039270A
Authority
CA
Canada
Prior art keywords
cephem
carboxylate
nitrobenzyl
thienyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA237,876A
Other languages
English (en)
French (fr)
Inventor
Robert R. Chauvette
Gary A. Koppel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of CA1039270A publication Critical patent/CA1039270A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
CA237,876A 1974-12-13 1975-10-17 3-thio-substituted cephalosporin antibiotics Expired CA1039270A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/532,431 US3992377A (en) 1974-12-13 1974-12-13 3-Thio-substituted cephalosporin antibiotics

Publications (1)

Publication Number Publication Date
CA1039270A true CA1039270A (en) 1978-09-26

Family

ID=24121771

Family Applications (1)

Application Number Title Priority Date Filing Date
CA237,876A Expired CA1039270A (en) 1974-12-13 1975-10-17 3-thio-substituted cephalosporin antibiotics

Country Status (11)

Country Link
US (1) US3992377A (US20050192411A1-20050901-C00001.png)
JP (1) JPS5182292A (US20050192411A1-20050901-C00001.png)
BE (1) BE836565A (US20050192411A1-20050901-C00001.png)
CA (1) CA1039270A (US20050192411A1-20050901-C00001.png)
CH (1) CH620216A5 (US20050192411A1-20050901-C00001.png)
DE (1) DE2555858A1 (US20050192411A1-20050901-C00001.png)
FR (1) FR2293935A1 (US20050192411A1-20050901-C00001.png)
GB (1) GB1526978A (US20050192411A1-20050901-C00001.png)
IE (1) IE41918B1 (US20050192411A1-20050901-C00001.png)
IL (1) IL48341A (US20050192411A1-20050901-C00001.png)
NL (1) NL7514557A (US20050192411A1-20050901-C00001.png)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH605997A5 (US20050192411A1-20050901-C00001.png) * 1974-08-30 1978-10-13 Ciba Geigy Ag
US4150156A (en) * 1975-11-21 1979-04-17 Merck & Co., Inc. 7-(Substituted methyl)-3-(substituted thio)-cephalosporins, derivatives and pharmaceutical compositions containing them
ZA766941B (en) * 1975-11-21 1978-06-28 Merck & Co Inc 3-(substituted thio)cephalosporins,derivatives and nuclear analogues thereof
US4197402A (en) * 1976-08-09 1980-04-08 Shionogi & Co., Ltd. Cephalosporin analogues
JPS53103493A (en) * 1977-02-18 1978-09-08 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
FR2418233A2 (fr) * 1978-02-22 1979-09-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkylthio ou 3-acylamino 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4739048A (en) * 1980-05-29 1988-04-19 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
US4745188A (en) * 1980-11-21 1988-05-17 Merck & Co., Inc. Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
GR76342B (US20050192411A1-20050901-C00001.png) * 1981-02-02 1984-08-06 Fujisawa Pharmaceutical Co
JPS5984890A (ja) 1982-11-05 1984-05-16 Hisayasu Ishimaru 経口用セフアロスポリン化合物
FR2550200B1 (fr) * 1983-08-01 1988-04-08 Fujisawa Pharmaceutical Co Procede de preparation de composes de cephem a activite antimicrobienne et nouveaux produits ainsi obtenus
JPH0686459B2 (ja) * 1989-12-07 1994-11-02 明治製菓株式会社 ３―置換チオ―３―セフエム化合物の製造法
JP2857532B2 (ja) * 1992-03-12 1999-02-17 明治製菓株式会社 新規セファロスポリン誘導体
US5698547A (en) * 1994-04-01 1997-12-16 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
LT4193B (en) 1994-04-01 1997-07-25 Microcide Pharmaceuticals Inc Cephalosporin antibiotics
US5789584A (en) * 1994-04-01 1998-08-04 Microcide Pharmaceuticals, Inc. Substituted-pyridinyl cephalosporin antibiotics active against methicillin resistant bacteria
US5551306A (en) * 1994-12-06 1996-09-03 Hersey Measurement Company Magnetic flowmeter
WO1996017850A1 (en) * 1994-12-09 1996-06-13 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and pharmaceutical use thereof
WO1996038450A1 (en) * 1995-05-31 1996-12-05 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
MY127641A (en) * 1995-10-12 2006-12-29 Essential Therapeutics Inc Cephalosporin antibiotics
AUPN801196A0 (en) * 1996-02-12 1996-03-07 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and pharmaceutical use thereof
US6025352A (en) * 1997-09-29 2000-02-15 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US6030965A (en) * 1997-09-30 2000-02-29 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
AR035728A1 (es) * 2001-01-16 2004-07-07 Merck & Co Inc Proceso perfeccionado para la sintesis de carbapenem

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds

Also Published As

Publication number Publication date
CH620216A5 (US20050192411A1-20050901-C00001.png) 1980-11-14
NL7514557A (nl) 1976-06-15
JPS5182292A (en) 1976-07-19
IE41918L (en) 1976-06-13
FR2293935A1 (fr) 1976-07-09
GB1526978A (en) 1978-10-04
BE836565A (fr) 1976-06-11
IL48341A (en) 1980-05-30
US3992377A (en) 1976-11-16
FR2293935B1 (US20050192411A1-20050901-C00001.png) 1979-09-21
DE2555858A1 (de) 1976-06-16
IE41918B1 (en) 1980-04-23
IL48341A0 (en) 1975-12-31

Similar Documents

Publication Publication Date Title
CA1039270A (en) 3-thio-substituted cephalosporin antibiotics
US4297488A (en) 7-α-Methoxy cephalosporins
US4520022A (en) Substituted vinyl cephalosporins
US4065620A (en) 3-(Substituted) vinyl cephalosporins
US3994885A (en) Process for etherifying β-lactam antibiotics
DK147683B (da) Analogifremgangsmaade til fremstilling af cephalosporinforbindelser eller ugiftige salte, biologisk acceptable estere, 1-oxyder eller solvater deraf
US3674784A (en) 3-formyl cephalosporin sulfoxides
US4369312A (en) Method of producing oxo-containing azetidinone compounds
GB2031425A (en) 3-unsubstituted-3-cephem compounds
GB2071654A (en) Hydroxamic acid derivatives of 7-(2-amino-4-thiazolyl)oximino cephalosporins
US3849408A (en) 4-substituted-delta2-cephalosporin derivatives
US3637678A (en) Delta-2 cephalosporin compounds
US4044000A (en) Substituted β-lactam antibiotics
US4049806A (en) Cephalosporin type antibacterials
US4661590A (en) Substituted vinyl cephalosporins
JPH04225985A (ja) セフアロスポリン化合物
CA1072949A (en) Cephem compounds
US3941779A (en) Method for producing 2-(substituted thio)-3-cephem derivatives
US3998950A (en) 7-αHydrazinoacetamido derivatives of cephalosporanic
US3985737A (en) 3-Sulfonate esters of cephalosporin
US4179502A (en) 7[2-Hydroxyiminoacetamido]cephalosporins
US4224441A (en) Derivatives of 7-aminocephalosporanic acid
US3708480A (en) 3-cyanomethyl-delta-3-cephalosporin antibiotics and intermediates
US3813391A (en) 7-(beta-(o-aminomethylphenyl)propion-amido)-3-(tetrazolo(4,5-b)pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acid
AU599676B2 (en) 7-(substituted amino-3-substituted cephalosporanic acids and esters