CA1032944A - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- CA1032944A CA1032944A CA204,832A CA204832A CA1032944A CA 1032944 A CA1032944 A CA 1032944A CA 204832 A CA204832 A CA 204832A CA 1032944 A CA1032944 A CA 1032944A
- Authority
- CA
- Canada
- Prior art keywords
- indole derivatives
- indole
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/43—Indoles; Hydrogenated indoles with an —OCH2CH(OH)CH2NH2 radical, which may be further substituted, attached in positions 4, 5, 6 or 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732337461 DE2337461A1 (de) | 1973-07-24 | 1973-07-24 | Neue indolderivate und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1032944A true CA1032944A (en) | 1978-06-13 |
Family
ID=5887789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA204,832A Expired CA1032944A (en) | 1973-07-24 | 1974-07-15 | Indole derivatives |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3929793A (xx) |
| JP (1) | JPS5041880A (xx) |
| AR (2) | AR205165A1 (xx) |
| AT (1) | AT337170B (xx) |
| CA (1) | CA1032944A (xx) |
| CH (2) | CH605923A5 (xx) |
| DE (1) | DE2337461A1 (xx) |
| ES (1) | ES428385A1 (xx) |
| FI (1) | FI221874A (xx) |
| FR (1) | FR2238495B1 (xx) |
| GB (1) | GB1422295A (xx) |
| NL (1) | NL7409858A (xx) |
| SE (1) | SE7409560L (xx) |
| ZA (1) | ZA744661B (xx) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0005828B1 (de) * | 1978-06-06 | 1981-03-11 | Hoechst Aktiengesellschaft | Neue substituierte Phenylpiperazinderivate, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung |
| DE2824764A1 (de) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung |
| DE2827566A1 (de) * | 1978-06-23 | 1980-01-10 | Boehringer Mannheim Gmbh | 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung |
| WO1980000152A1 (en) | 1978-07-03 | 1980-02-07 | Sandoz Ag | 3-aminopropoxy-aryl derivates,preparation and use thereof |
| DE2834114A1 (de) * | 1978-08-01 | 1980-02-14 | Schering Ag | Polyalkoxyphenylpyrrolidone iii, verfahren zu ihrer herstellung und ihre verwendung |
| US4259327A (en) * | 1979-04-02 | 1981-03-31 | Merck & Co., Inc. | Substituted aminoalkoxypyridines, compositions and use thereof |
| DE3068678D1 (en) * | 1979-08-10 | 1984-08-30 | Sandoz Ag | 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them |
| ZA804848B (en) * | 1979-08-10 | 1982-03-31 | Sandoz Ltd | 3-aminopropoxy deri-vatives, their preparation and pharmaceutical compositions containing them |
| JPS56122351A (en) * | 1980-02-29 | 1981-09-25 | Otsuka Pharmaceut Co Ltd | Oxyindole derivative |
| US4349673A (en) * | 1980-12-23 | 1982-09-14 | Merck & Co., Inc. | Benzoxazines |
| US4656168A (en) * | 1980-12-23 | 1987-04-07 | Merck & Co., Inc. | (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation |
| US4331679A (en) * | 1980-12-23 | 1982-05-25 | Merck Sharp & Dohme (I.A.) Corp. | (3-Aralkylamino-2-or-propoxy) heterocyclic compounds |
| US4442094A (en) * | 1980-12-23 | 1984-04-10 | Merck & Co., Inc. | (3-Aralkylamino-2-or-propoxy)heterocyclic compounds |
| DE3200304A1 (de) * | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| DE3424685A1 (de) * | 1984-07-05 | 1986-02-06 | Beiersdorf Ag, 2000 Hamburg | Neue substituierte phenylpiperazinyl-propanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen |
| DE3582371D1 (de) * | 1984-07-06 | 1991-05-08 | Otsuka Pharma Co Ltd | Oxindolverbindungen, diese enthaltende zusammensetzungen sowie verfahren zur herstellung derselben. |
| US4704390A (en) * | 1986-02-13 | 1987-11-03 | Warner-Lambert Company | Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
| DE3923045A1 (de) * | 1989-07-13 | 1991-01-17 | Merck Patent Gmbh | Indolderivate |
| DE4002391A1 (de) * | 1990-01-27 | 1991-08-01 | Beiersdorf Ag | Indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| FR2699918B1 (fr) * | 1992-12-30 | 1995-03-17 | Pf Medicament | Ligands sélectifs des récepteurs 5HY1D-5HT1B dérivés d'indole-pipérazine utiles comme médicaments. |
| US5789402A (en) * | 1995-01-17 | 1998-08-04 | Eli Lilly Company | Compounds having effects on serotonin-related systems |
| US5614523A (en) * | 1995-01-17 | 1997-03-25 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5741789A (en) * | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5627196A (en) * | 1995-01-17 | 1997-05-06 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| EP1188747B1 (en) | 1999-05-24 | 2005-09-07 | Mitsubishi Pharma Corporation | Phenoxypropylamine compounds |
| DE60026581T2 (de) * | 1999-12-20 | 2006-12-28 | Eli Lilly And Co., Indianapolis | Indolderivate zur behandlung von depression und angstzuständen |
| US20090099201A1 (en) * | 2007-05-22 | 2009-04-16 | David Robert Bolin | Diacylglycerol Acyltransferase Inhibitors |
| US8058299B2 (en) * | 2007-05-22 | 2011-11-15 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8115011B2 (en) * | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8153644B2 (en) * | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8211884B2 (en) * | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| EP2367817A4 (en) * | 2008-12-03 | 2012-05-09 | Via Pharmaceuticals Inc | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE ENZYME |
| AU2009333333A1 (en) * | 2008-12-17 | 2011-06-30 | Via Pharmaceuticals, Inc | Inhibitors of diacylglycerol aclytransferase |
| CN102382032A (zh) * | 2010-08-30 | 2012-03-21 | 广州医学院 | 1-(苯基)-4-[3-(4-吲哚氧基)-2-羟基丙基]哌嗪衍生物及其盐、制备方法和应用 |
| US9951088B2 (en) * | 2012-05-09 | 2018-04-24 | Sunovion Pharmaceuticals Inc. | D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH489497A (de) * | 1967-01-25 | 1970-04-30 | Geigy Ag J R | Verfahren zur Herstellung von neuen Indolderivaten |
| BE756127A (fr) * | 1969-09-12 | 1971-03-15 | Hoechst Ag | Ethers heterocycliques et leur preparation |
-
1973
- 1973-07-24 DE DE19732337461 patent/DE2337461A1/de active Pending
-
1974
- 1974-01-01 AR AR254831A patent/AR205165A1/es active
- 1974-06-28 US US484354A patent/US3929793A/en not_active Expired - Lifetime
- 1974-07-15 CA CA204,832A patent/CA1032944A/en not_active Expired
- 1974-07-17 ES ES428385A patent/ES428385A1/es not_active Expired
- 1974-07-19 FI FI2218/74A patent/FI221874A/fi unknown
- 1974-07-19 GB GB3210674A patent/GB1422295A/en not_active Expired
- 1974-07-19 CH CH1601677A patent/CH605923A5/xx not_active IP Right Cessation
- 1974-07-19 CH CH1001474A patent/CH605921A5/xx not_active IP Right Cessation
- 1974-07-22 NL NL7409858A patent/NL7409858A/xx not_active Application Discontinuation
- 1974-07-22 AT AT603074A patent/AT337170B/de not_active IP Right Cessation
- 1974-07-22 ZA ZA00744661A patent/ZA744661B/xx unknown
- 1974-07-23 SE SE7409560A patent/SE7409560L/xx unknown
- 1974-07-23 FR FR7425484A patent/FR2238495B1/fr not_active Expired
- 1974-07-24 JP JP49085041A patent/JPS5041880A/ja active Pending
-
1975
- 1975-01-01 AR AR258550A patent/AR204753A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| NL7409858A (nl) | 1975-01-28 |
| DE2337461A1 (de) | 1975-02-06 |
| FR2238495A1 (xx) | 1975-02-21 |
| US3929793A (en) | 1975-12-30 |
| ZA744661B (en) | 1975-09-24 |
| ATA603074A (de) | 1976-10-15 |
| AU7134074A (en) | 1976-01-22 |
| AT337170B (de) | 1977-06-10 |
| SE7409560L (xx) | 1975-01-27 |
| JPS5041880A (xx) | 1975-04-16 |
| AR204753A1 (es) | 1976-02-27 |
| CH605923A5 (xx) | 1978-10-13 |
| FI221874A (xx) | 1975-01-25 |
| CH605921A5 (xx) | 1978-10-13 |
| ES428385A1 (es) | 1976-07-16 |
| GB1422295A (en) | 1976-01-21 |
| AR205165A1 (es) | 1976-04-12 |
| FR2238495B1 (xx) | 1978-07-21 |
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