CA1022158A - Alkylated pregnanes and process for obtaining same - Google Patents

Alkylated pregnanes and process for obtaining same

Info

Publication number
CA1022158A
CA1022158A CA161,016A CA161016A CA1022158A CA 1022158 A CA1022158 A CA 1022158A CA 161016 A CA161016 A CA 161016A CA 1022158 A CA1022158 A CA 1022158A
Authority
CA
Canada
Prior art keywords
pregnanes
alkylated
obtaining same
obtaining
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA161,016A
Other languages
English (en)
Other versions
CA161016S (en
Inventor
George Mcgarry
Gilbert F. Woods
James Cairns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzona Inc
Original Assignee
Akzona Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzona Inc filed Critical Akzona Inc
Application granted granted Critical
Publication of CA1022158A publication Critical patent/CA1022158A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA161,016A 1972-01-12 1973-01-11 Alkylated pregnanes and process for obtaining same Expired CA1022158A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB153472A GB1416427A (en) 1972-01-12 1972-01-12 Alkylated pregnanes and process for obtaining same

Publications (1)

Publication Number Publication Date
CA1022158A true CA1022158A (en) 1977-12-06

Family

ID=9723658

Family Applications (1)

Application Number Title Priority Date Filing Date
CA161,016A Expired CA1022158A (en) 1972-01-12 1973-01-11 Alkylated pregnanes and process for obtaining same

Country Status (17)

Country Link
US (1) US3862194A (fr)
JP (1) JPS5614678B2 (fr)
AT (1) AT367068B (fr)
BE (1) BE793958A (fr)
CA (1) CA1022158A (fr)
CH (1) CH615934A5 (fr)
DE (1) DE2301317C2 (fr)
DK (1) DK139031B (fr)
FI (1) FI52587C (fr)
FR (1) FR2168006B1 (fr)
GB (1) GB1416427A (fr)
HU (1) HU167205B (fr)
IE (1) IE37048B1 (fr)
IL (1) IL41160A (fr)
NL (2) NL179287C (fr)
PH (1) PH9719A (fr)
SE (1) SE411213B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947478A (en) * 1972-01-12 1976-03-30 Akzona Incorporated Alkylated 3,20-diketo-Δ4 -steroids of the pregnane series
GB1436324A (en) * 1972-05-12 1976-05-19 Glaxo Lab Ltd Anaesthetic 3alpha-hydroxy pregnanes
US4031075A (en) * 1973-07-11 1977-06-21 Akzona Incorporated Alkylated pregnanes and process for obtaining same
GB1478968A (en) * 1973-07-11 1977-07-06 Akzo Nv Alkylated pregnanes
JPS5264666A (en) * 1975-11-25 1977-05-28 Sharp Kk Bothhside circuit substrate
EP0014005B1 (fr) * 1979-01-24 1983-08-03 Akzo N.V. Pregnanes alcoylés, procédés pour leur préparation et compositions pharmaceutiques les contenant
JPS58194A (ja) * 1981-06-25 1983-01-05 北陸電気工業株式会社 Ｃｕ粉末導電塗料を用いた印刷抵抗回路基板の製造方法
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
WO1991014700A2 (fr) * 1990-03-27 1991-10-03 Schering Corporation PROCEDE DE DESHYDRATATION DE 9α-HYDROXY STEROIDES
JP2000502102A (ja) * 1995-12-20 2000-02-22 シェーリング コーポレイション ９，１１β―エポキシドステロイドの調製方法
AU4918697A (en) * 1996-10-25 1998-05-22 Alcon Laboratories, Inc. Method of preparing 21-alkylated pregna-1,4,16-trien-3,20-diones
US6040468A (en) * 1996-10-25 2000-03-21 Alcon Laboratories, Inc. Method of preparing 16α, 17α-dialkylated steroids
HUP0003354A3 (en) * 1997-06-04 2001-09-28 Akzo Nobel Nv Use of anti-inflammatory steroids for the preparation of pharmaceutical compositions of chronic inflammatory intestinal diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3064017A (en) * 1962-11-13 Preparation viii
US3047594A (en) * 1960-05-11 1962-07-31 Pfizer & Co C Preparation of 21-methyl steroids and intermediates
US3114750A (en) * 1960-11-07 1963-12-17 British Drug Houses Ltd 3-enol ethers of 6-formyl-3-oxo-delta4-steroids and process for their preparation
US3166551A (en) * 1962-01-02 1965-01-19 British Drug Houses Ltd Process for the preparation of 3-oxo-delta4-6-methyl steroids
DE1167829B (de) * 1962-08-03 1964-04-16 Schering Ag Verfahren zur Herstellung von 21-Methyl-í¸-pregnen-11ª‰, 17ª‡-diol-3, 20-dion
US3594407A (en) * 1969-04-03 1971-07-20 American Home Prod 13,17-dialkyl-19-norpregn-4-ene,3,20-diones

Also Published As

Publication number Publication date
FR2168006A1 (fr) 1973-08-24
DE2301317A1 (de) 1973-07-26
FI52587C (fi) 1977-10-10
SE411213B (sv) 1979-12-10
PH9719A (en) 1976-02-27
HU167205B (fr) 1975-09-27
IL41160A (en) 1977-04-29
DE2301317C2 (de) 1983-11-03
NL179287B (nl) 1986-03-17
BE793958A (fr) 1973-07-12
FR2168006B1 (fr) 1976-09-03
FI52587B (fr) 1977-06-30
IE37048L (en) 1973-07-12
ATA28373A (de) 1981-10-15
NL179287C (nl) 1986-08-18
CH615934A5 (fr) 1980-02-29
JPS5614678B2 (fr) 1981-04-06
GB1416427A (en) 1975-12-03
US3862194A (en) 1975-01-21
DK139031C (fr) 1979-05-14
IE37048B1 (en) 1977-04-27
IL41160A0 (en) 1973-02-28
JPS504060A (fr) 1975-01-16
NL7300313A (fr) 1973-07-16
NL930031I1 (nl) 1993-07-01
DK139031B (da) 1978-12-04
AT367068B (de) 1982-05-25

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