CA1015758A - 6,7-dihydro-1-oxo-n(1h-tetrazol-5-yl)-1h,5h-benzo(ij)quinolizine-2-carboxamides - Google Patents

6,7-dihydro-1-oxo-n(1h-tetrazol-5-yl)-1h,5h-benzo(ij)quinolizine-2-carboxamides

Info

Publication number
CA1015758A
CA1015758A CA197,107A CA197107A CA1015758A CA 1015758 A CA1015758 A CA 1015758A CA 197107 A CA197107 A CA 197107A CA 1015758 A CA1015758 A CA 1015758A
Authority
CA
Canada
Prior art keywords
quinolizine
carboxamides
tetrazol
benzo
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA197,107A
Other languages
English (en)
Other versions
CA197107S (en
Inventor
Heulwen M. Ridgway
David E. Bays
Gwynn P. Ellis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Application granted granted Critical
Publication of CA1015758A publication Critical patent/CA1015758A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA197,107A 1973-04-05 1974-04-05 6,7-dihydro-1-oxo-n(1h-tetrazol-5-yl)-1h,5h-benzo(ij)quinolizine-2-carboxamides Expired CA1015758A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1627973A GB1433151A (en) 1973-04-05 1973-04-05 Benzo-ij-quinolizines

Publications (1)

Publication Number Publication Date
CA1015758A true CA1015758A (en) 1977-08-16

Family

ID=10074459

Family Applications (1)

Application Number Title Priority Date Filing Date
CA197,107A Expired CA1015758A (en) 1973-04-05 1974-04-05 6,7-dihydro-1-oxo-n(1h-tetrazol-5-yl)-1h,5h-benzo(ij)quinolizine-2-carboxamides

Country Status (14)

Country Link
US (1) US3917608A (e)
JP (1) JPS5024296A (e)
AT (1) AT330180B (e)
AU (1) AU6720074A (e)
BE (1) BE813158A (e)
CA (1) CA1015758A (e)
CH (1) CH602722A5 (e)
DE (1) DE2415763A1 (e)
FR (1) FR2230355B1 (e)
GB (1) GB1433151A (e)
IE (1) IE39101B1 (e)
LU (1) LU69756A1 (e)
NL (1) NL7404719A (e)
ZA (1) ZA741860B (e)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051247A (en) * 1975-04-14 1977-09-27 Riker Laboratories, Inc. Method of using 7-hydroxy-benzo[ij]quinolizine-2-carboxylic acid derivatives
AT377986B (de) * 1978-08-31 1985-05-28 Otsuka Pharma Co Ltd Verfahren zur herstellung von neuen piperazinylbenzoheterozyklischen verbindungen und ihren pharmazeutisch annehmbaren salzen
JPS5540616A (en) * 1978-09-14 1980-03-22 Otsuka Pharmaceut Co Ltd Preparation of benzo-hetero-compound
AT377987B (de) * 1979-04-11 1985-05-28 Otsuka Pharma Co Ltd Verfahren zur herstellung von neuen piperazinylbenzoheterozyklischen verbindungen und ihren pharmazeutisch annehmbaren salzen
US4400386A (en) * 1981-11-06 1983-08-23 Riker Laboratories, Inc. Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine
US4472407A (en) * 1983-03-17 1984-09-18 Riker Laboratories, Inc. Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu
US4650804A (en) * 1984-03-30 1987-03-17 Fujisawa Pharmaceutical Co., Ltd. Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents
CA1266484A (en) * 1984-12-14 1990-03-06 Ronald Edward Mac Leay Tert-octylhydrazine, its salts and derivatives
DE3519926A1 (de) * 1985-06-04 1986-12-04 Bayer Ag Indolinderivate, verfahren zu ihrer herstellung und diese indolinderivate enthaltende kosmetische lichtschutzmittel
EP0882046A1 (en) * 1996-02-21 1998-12-09 Darwin Discovery Limited Quinolones and their therapeutic use
US5792774A (en) * 1996-02-21 1998-08-11 Chiroscience Limited Quinolones and their therapeutic use
AU710876B2 (en) * 1996-02-21 1999-09-30 Darwin Discovery Limited Quinolones and their therapeutic use
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
RU2528046C2 (ru) * 2004-06-24 2014-09-10 Вертекс Фармасьютикалз Инкорпорейтед Модуляторы транспортеров атф-связывающей кассеты
ES2656017T3 (es) 2004-06-24 2018-02-22 Vertex Pharmaceuticals Incorporated Moduladores de transportadores del casete de unión a ATP
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
EP2502912A3 (en) * 2004-06-24 2013-11-06 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
EP3330255B1 (en) 2009-03-20 2020-12-09 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
AU2013226076B2 (en) 2012-02-27 2017-11-16 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administration thereof
JP6746569B2 (ja) 2014-10-07 2020-08-26 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728350A (en) * 1967-07-17 1973-04-17 Lilly Co Eli 1-(2-carboxyphenyl)-5,7-dimethoxy-3,4-dihydrocarbostyril intermediates for acronycis
US3793328A (en) * 1969-11-03 1974-02-19 Upjohn Co 8benzoyl 1,2,3,4 tetrahydroquinoline
BE789822A (fr) * 1971-10-08 1973-04-06 Allen & Hanburys Ltd Nouveaux composes heterocycliques
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives

Also Published As

Publication number Publication date
LU69756A1 (e) 1975-06-16
NL7404719A (e) 1974-10-08
DE2415763A1 (de) 1974-10-17
AU6720074A (en) 1975-10-02
FR2230355B1 (e) 1977-05-06
AT330180B (de) 1976-06-25
BE813158A (fr) 1974-10-01
FR2230355A1 (e) 1974-12-20
ZA741860B (en) 1975-02-26
IE39101B1 (en) 1978-08-02
CH602722A5 (e) 1978-07-31
GB1433151A (en) 1976-04-22
US3917608A (en) 1975-11-04
JPS5024296A (e) 1975-03-15
IE39101L (en) 1974-10-05
ATA277074A (de) 1975-09-15
AU474838B2 (e) 1976-08-05

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