JPS5024296A - - Google Patents
Info
- Publication number
- JPS5024296A JPS5024296A JP49039368A JP3936874A JPS5024296A JP S5024296 A JPS5024296 A JP S5024296A JP 49039368 A JP49039368 A JP 49039368A JP 3936874 A JP3936874 A JP 3936874A JP S5024296 A JPS5024296 A JP S5024296A
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1627973A GB1433151A (en) | 1973-04-05 | 1973-04-05 | Benzo-ij-quinolizines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5024296A true JPS5024296A (e) | 1975-03-15 |
Family
ID=10074459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP49039368A Pending JPS5024296A (e) | 1973-04-05 | 1974-04-05 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3917608A (e) |
| JP (1) | JPS5024296A (e) |
| AT (1) | AT330180B (e) |
| AU (1) | AU6720074A (e) |
| BE (1) | BE813158A (e) |
| CA (1) | CA1015758A (e) |
| CH (1) | CH602722A5 (e) |
| DE (1) | DE2415763A1 (e) |
| FR (1) | FR2230355B1 (e) |
| GB (1) | GB1433151A (e) |
| IE (1) | IE39101B1 (e) |
| LU (1) | LU69756A1 (e) |
| NL (1) | NL7404719A (e) |
| ZA (1) | ZA741860B (e) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5540616A (en) * | 1978-09-14 | 1980-03-22 | Otsuka Pharmaceut Co Ltd | Preparation of benzo-hetero-compound |
| JPS61151160A (ja) * | 1984-12-14 | 1986-07-09 | ペンウオルト・コーポレーシヨン | 第三オクチルヒドラジン、その塩および誘導体 |
| JP2008504291A (ja) * | 2004-06-24 | 2008-02-14 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターのモジュレーター |
| US9670163B2 (en) | 2005-12-28 | 2017-06-06 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US9701639B2 (en) | 2014-10-07 | 2017-07-11 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| US9751839B2 (en) | 2009-03-20 | 2017-09-05 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US10272046B2 (en) | 2012-02-27 | 2019-04-30 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US10646481B2 (en) | 2008-08-13 | 2020-05-12 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4051247A (en) * | 1975-04-14 | 1977-09-27 | Riker Laboratories, Inc. | Method of using 7-hydroxy-benzo[ij]quinolizine-2-carboxylic acid derivatives |
| AT377986B (de) * | 1978-08-31 | 1985-05-28 | Otsuka Pharma Co Ltd | Verfahren zur herstellung von neuen piperazinylbenzoheterozyklischen verbindungen und ihren pharmazeutisch annehmbaren salzen |
| AT377987B (de) * | 1979-04-11 | 1985-05-28 | Otsuka Pharma Co Ltd | Verfahren zur herstellung von neuen piperazinylbenzoheterozyklischen verbindungen und ihren pharmazeutisch annehmbaren salzen |
| US4400386A (en) * | 1981-11-06 | 1983-08-23 | Riker Laboratories, Inc. | Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine |
| US4472407A (en) * | 1983-03-17 | 1984-09-18 | Riker Laboratories, Inc. | Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu |
| US4650804A (en) * | 1984-03-30 | 1987-03-17 | Fujisawa Pharmaceutical Co., Ltd. | Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents |
| DE3519926A1 (de) * | 1985-06-04 | 1986-12-04 | Bayer Ag | Indolinderivate, verfahren zu ihrer herstellung und diese indolinderivate enthaltende kosmetische lichtschutzmittel |
| EP0882046A1 (en) * | 1996-02-21 | 1998-12-09 | Darwin Discovery Limited | Quinolones and their therapeutic use |
| US5792774A (en) * | 1996-02-21 | 1998-08-11 | Chiroscience Limited | Quinolones and their therapeutic use |
| AU710876B2 (en) * | 1996-02-21 | 1999-09-30 | Darwin Discovery Limited | Quinolones and their therapeutic use |
| RU2528046C2 (ru) * | 2004-06-24 | 2014-09-10 | Вертекс Фармасьютикалз Инкорпорейтед | Модуляторы транспортеров атф-связывающей кассеты |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| EP2502912A3 (en) * | 2004-06-24 | 2013-11-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3728350A (en) * | 1967-07-17 | 1973-04-17 | Lilly Co Eli | 1-(2-carboxyphenyl)-5,7-dimethoxy-3,4-dihydrocarbostyril intermediates for acronycis |
| US3793328A (en) * | 1969-11-03 | 1974-02-19 | Upjohn Co | 8benzoyl 1,2,3,4 tetrahydroquinoline |
| BE789822A (fr) * | 1971-10-08 | 1973-04-06 | Allen & Hanburys Ltd | Nouveaux composes heterocycliques |
| BE793524A (fr) * | 1971-12-30 | 1973-06-29 | Riker Laboratories Inc | Acides benzoquinolizine-carboxyliques et leurs derives |
-
1973
- 1973-04-05 GB GB1627973A patent/GB1433151A/en not_active Expired
-
1974
- 1974-03-21 ZA ZA00741860A patent/ZA741860B/xx unknown
- 1974-03-25 IE IE649/74A patent/IE39101B1/xx unknown
- 1974-03-27 AU AU67200/74A patent/AU6720074A/en not_active Expired
- 1974-03-27 US US455071A patent/US3917608A/en not_active Expired - Lifetime
- 1974-04-01 DE DE2415763A patent/DE2415763A1/de active Pending
- 1974-04-01 BE BE142731A patent/BE813158A/xx unknown
- 1974-04-01 LU LU69756A patent/LU69756A1/xx unknown
- 1974-04-02 CH CH462974A patent/CH602722A5/xx not_active IP Right Cessation
- 1974-04-03 FR FR7411776A patent/FR2230355B1/fr not_active Expired
- 1974-04-03 AT AT277074A patent/AT330180B/de not_active IP Right Cessation
- 1974-04-05 JP JP49039368A patent/JPS5024296A/ja active Pending
- 1974-04-05 NL NL7404719A patent/NL7404719A/xx not_active Application Discontinuation
- 1974-04-05 CA CA197,107A patent/CA1015758A/en not_active Expired
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5540616A (en) * | 1978-09-14 | 1980-03-22 | Otsuka Pharmaceut Co Ltd | Preparation of benzo-hetero-compound |
| JPS6237628B2 (e) * | 1978-09-14 | 1987-08-13 | Otsuka Pharma Co Ltd | |
| JPS61151160A (ja) * | 1984-12-14 | 1986-07-09 | ペンウオルト・コーポレーシヨン | 第三オクチルヒドラジン、その塩および誘導体 |
| JP2008504291A (ja) * | 2004-06-24 | 2008-02-14 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターのモジュレーター |
| JP2012062319A (ja) * | 2004-06-24 | 2012-03-29 | Vertex Pharmaceuticals Inc | Ａｔｐ結合カセットトランスポーターのモジュレーター |
| JP2012107069A (ja) * | 2004-06-24 | 2012-06-07 | Vertex Pharmaceuticals Inc | Ａｔｐ結合カセットトランスポーターのモジュレーター |
| JP2014156468A (ja) * | 2004-06-24 | 2014-08-28 | Vertex Pharmaceuticals Inc | Ａｔｐ結合カセットトランスポーターのモジュレーター |
| US10662192B2 (en) | 2004-06-24 | 2020-05-26 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US10537565B2 (en) | 2005-12-28 | 2020-01-21 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US9931334B2 (en) | 2005-12-28 | 2018-04-03 | Vertex Pharmaceuticals Incorporated | Solid forms of N[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US9670163B2 (en) | 2005-12-28 | 2017-06-06 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US11291662B2 (en) | 2005-12-28 | 2022-04-05 | Vertex Pharmaceuticals Incorporated | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US10646481B2 (en) | 2008-08-13 | 2020-05-12 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US11564916B2 (en) | 2008-08-13 | 2023-01-31 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US9751839B2 (en) | 2009-03-20 | 2017-09-05 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US10272046B2 (en) | 2012-02-27 | 2019-04-30 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US11147770B2 (en) | 2012-02-27 | 2021-10-19 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US11752106B2 (en) | 2012-02-27 | 2023-09-12 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US9701639B2 (en) | 2014-10-07 | 2017-07-11 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
Also Published As
| Publication number | Publication date |
|---|---|
| LU69756A1 (e) | 1975-06-16 |
| NL7404719A (e) | 1974-10-08 |
| DE2415763A1 (de) | 1974-10-17 |
| CA1015758A (en) | 1977-08-16 |
| AU6720074A (en) | 1975-10-02 |
| FR2230355B1 (e) | 1977-05-06 |
| AT330180B (de) | 1976-06-25 |
| BE813158A (fr) | 1974-10-01 |
| FR2230355A1 (e) | 1974-12-20 |
| ZA741860B (en) | 1975-02-26 |
| IE39101B1 (en) | 1978-08-02 |
| CH602722A5 (e) | 1978-07-31 |
| GB1433151A (en) | 1976-04-22 |
| US3917608A (en) | 1975-11-04 |
| IE39101L (en) | 1974-10-05 |
| ATA277074A (de) | 1975-09-15 |
| AU474838B2 (e) | 1976-08-05 |